Keyword: alzheimers
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OK - you want something to scare you to death, put things into perspective? BOBBY VEE? Everything about him SCREAMS teenager.
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WASHINGTON – Pat Summitt, the former head coach of the University of Tennessee’s women’s basketball team, will receive the Presidential Medal of Freedom, the White House announced Thursday. Summitt, the winningest coach in basketball history, announced her retirement Wednesday after coaching the Lady Volunteers for 38 years. Summitt was diagnosed less than a year ago with early-onset Alzheimer's disease.(Snip) The Medal of Freedom is the nation’s highest civilian honor. It is presented annually to people who have made exceptional contributions “to the security or national interests of the United States, to world peace, or to cultural or other significant public...
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Doctors are calling for a clinical trial of an experimental drug treatment that it is claimed can reverse the symptoms of Alzheimer's disease "in minutes". U.S. researchers say the treatment allowed an 82-year- old sufferer to recognise his wife for the first time in years. In the UK, specialists believe the claims should be properly tested as only a few patients have been treated so far. The treatment involves injecting a drug called Enbrel - which is normally used to treat arthritis - into the spine at the neck. Patients are then tilted to encourage blood flow into the brain...
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A new study of a promising Alzheimer's treatment has doctors buzzing that the drug may reverse the deadly neurodegenerative disease. But the new treatment isn't a new drug at all, rather a skin cancer pill that's been FDA-approved for more than a decade. The drug, bexarotene, reversed signs of Alzheimer's in mice brains and also improved their memory in as little as 72 hours, according to the study. "This is an unprecedented finding," study author Paige Cramer, a PhD candidate at Case Western Reserve School of Medicine, said in a university written statement. "Previously, the best existing treatment for Alzheimer's...
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We've been waiting and hoping that the Rhinestone Cowboy might come to Orange County one last time before finally hanging up his microphone, but it doesn't seem likely now -- not when a huge farewell has been slated for the Hollywood Bowl. As has been widely reported -- and repeated Sunday night just before the Lifetime Achievement Award honoree took the stage for a rousing, admirable tribute at the Grammys -- Glen Campbell, 76, is facing the onset of Alzheimer's by embarking on a farewell trek (The Goodbye Tour) behind one final album, his 61st (!), last August's acclaimed Ghost...
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A skin cancer drug has reversed Alzheimer's in mice - raising hope that it could be similarly successful against the incurable disease in humans. Now families of Alzheimer's sufferers are now bombarding physicians with requests for the drug, called bexarotene and marketed as Targretin. In research published in the journal Science, mice were engineered to exhibit Alzheimer's symptoms - such as forgetfulness and rapid cell death. After they took the drug, they became instantly smarter, performing better Researchers at Case Western Reserve University in Cleveland, Ohio added that plaque in the mice brains that was causing Alzheimer's had started to...
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A widely available cancer drug has shown remarkable success in reversing Alzheimer's disease in mice, raising hope of a breakthrough against incurable dementia in humans, US researchers said Thursday. Mice treated with the drug, known as bexarotene, became rapidly smarter and the plaque in their brains that was causing their Alzheimer's started to disappear within hours, said the research in the journal Science. "We were shocked and amazed," lead author Gary Landreth of the Department of Neurosciences at Case Western Reserve University School of Medicine in Ohio told AFP. "Things like this had never, ever been seen before," he said....
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Alzheimer’s disease seems to spread like an infection from brain cell to brain cell, two new studies in mice have found. But instead of viruses or bacteria, what is being spread is a distorted protein known as tau. The surprising finding answers a longstanding question and has immediate implications for developing treatments, researchers said. And they suspect that other degenerative brain diseases like Parkinson’s may spread in a similar way. Alzheimer’s researchers have long known that dying, tau-filled cells first emerge in a small area of the brain where memories are made and stored. The disease then slowly moves outward...
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Clarksburg, MD—Two different research groups have independently made the same important discoveries on how Alzheimer’s disease spreads in the brain, according to a February 2 New York Times story. The groups’ findings have the potential to give us a much more sophisticated understanding of what goes wrong in Alzheimer’s disease and, more importantly, what can be done to prevent or repair damage in the brain. The Times reported on the research teams of Bradley T. Hyman, MD, Ph.D., at Massachusetts General Hospital in Boston, and Karen E. Duff, Ph.D., of Columbia University Medical Center in New York. Each research group...
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Research into how iron, copper, zinc and other metals work in the brain may help unlock some of the secrets of degenerative diseases like Alzheimer's and Parkinson's. Iron and copper appear to accumulate beyond normal levels in the brains of people with these diseases, and a new, Australian study published Sunday shows reducing excess iron in the brain can alleviate Alzheimer's-like symptoms—at least in mice. A genetic mutation related to regulating iron is linked to ALS, or Lou Gehrig's disease. Zinc, on the other hand, appears to impair memory if its levels get too low or if it gets into...
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TED Event - a talk by Dr. Terry Wahls about how she essentially cured her own MS through diet.
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CORVALLIS, Ore. – New research has found that elderly people with higher levels of several vitamins and omega 3 fatty acids in their blood had better performance on mental acuity tests and less of the brain shrinkage typical of Alzheimer's disease – while "junk food" diets produced just the opposite result. The study was among the first of its type to specifically measure a wide range of blood nutrient levels instead of basing findings on less precise data such as food questionnaires, and found positive effects of high levels of vitamins B, C, D, E and the healthy oils most...
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Scientists have isolated a gene in mice that works to give them "super memories" and reverses the course of several degenerative mental illnesses like Alzheimer's. And because of the similarity of mice and human brains, a powerful brain pill for humans may now not be far off. The brains of both mice and humans release a gene known as PKR, which is triggered by the onset of Alzheimer's. But the newly discovered gene can apparently block PKR's release--a development that not only can reverse the course of degenerative brain diseases such as Alzheimer's, but induces a state of "super memory"...
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Statins, traditionally known as cholesterol-lowering drugs, may reduce mortality among patients hospitalized with influenza, according to a new study released online by the Journal of Infectious Diseases. It is the first published observational study to evaluate the relationship between statin use and mortality in hospitalized patients with laboratory-confirmed influenza virus infection, according to Vanderbilt's William Schaffner, M.D., professor and chair of Preventive Medicine. "We may be able to combine statins with antiviral drugs to provide better treatment for patients seriously ill with influenza," said Schaffner, who co-authored the study led by Meredith Vandermeer, MPH, of the Oregon Public Health Division.
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Salk scientists develop new drug that improves memory and prevents brain damage in miceA new drug candidate may be the first capable of halting the devastating mental decline of Alzheimer's disease, based on the findings of a study published today in PLoS one. When given to mice with Alzheimer's, the drug, known as J147, improved memory and prevented brain damage caused by the disease. The new compound, developed by scientists at the Salk Institute for Biological Studies, could be tested for treatment of the disease in humans in the near future. "J147 enhances memory in both normal and Alzheimer's mice...
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A surprisingly simple method to target harmful proteinsTroy, N.Y. – Researchers at Rensselaer Polytechnic Institute have developed a new method to design antibodies aimed at combating disease. The surprisingly simple process was used to make antibodies that neutralize the harmful protein particles that lead to Alzheimer's disease. The process is reported in the Dec. 5 Early Edition of the journal Proceedings of the National Academy of Sciences (PNAS). The process, outlined in the paper, titled "Structure-based design of conformation- and sequence-specific antibodies against amyloid β," could be used as a tool to understand complex disease pathology and develop new antibody-based...
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A red dye derived from lichens that has been used for centuries to color fabrics and food appears to reduce the abundance of small toxic protein aggregates in Alzheimer’s disease. The dye, a compound called orcein, and a related substance, called O4, bind preferentially to small amyloid aggregates that are considered to be toxic and cause neuronal dysfunction and memory impairment in Alzheimer’s disease. O4 binding to small aggregates promotes their conversion into large, mature plaques which researchers assume to be largely non-toxic for neuronal cells. Further research with animal models is needed to determine whether this new approach by...
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CHICAGO – People who eat baked or broiled fish on a weekly basis may be improving their brain health and reducing their risk of developing mild cognitive impairment (MCI) and Alzheimer's disease, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA). "This is the first study to establish a direct relationship between fish consumption, brain structure and Alzheimer's risk," said Cyrus Raji, M.D., Ph.D., from the University of Pittsburgh Medical Center and the University of Pittsburgh School of Medicine. "The results showed that people who consumed baked or broiled fish at...
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For decades the amyloid hypothesis has dominated the research field in Alzheimer’s disease. The theory describes how an increase in secreted beta-amyloid peptides leads to the formation of plaques, toxic clusters of damaged proteins between cells, which eventually result in neurodegeneration. Scientists at Lund University, Sweden, have now presented a study that turns this premise on its head. The research group’s data offers an opposite hypothesis, suggesting that it is in fact the neurons’ inability to secrete beta-amyloid that is at the heart of pathogenesis in Alzheimer’s disease. The study, published in the October issue of the Journal of Neuroscience,...
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DURHAM, N.C. - Immune system cells of the brain, which scavenge pathogens and damaged neurons, are also key players in memory and learning, according to new research by Duke neuroscientists. Earlier studies by Staci Bilbo, an assistant professor in psychology & neuroscience, had shown that laboratory rats experiencing an infection at an early age have an aggressive immune response to subsequent infections, which also harms their learning and memory. In a study published in the Oct. 26 Journal of Neuroscience, Bilbo's team identifies the source of the learning difficulties and traces it back to the immune system itself. The researchers...
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