How insulin, zinc and pH can block harmful protein clumps linked to type 2 diabetes
|
| |
Medical Xpress / Florida State University / Communications Biology ^
| Aug. 22, 2024 | Trisha Radulovich / Samuel D. McCalpin et al
An estimated 462 million people around the world suffer from type 2 diabetes, a chronic disease in which the body has problems using sugar as a fuel, leading to a buildup of sugar in the blood and chronic health issues. New
research shows how zinc, pH levels and insulin work together to inhibit the buildup of protein clumps that contribute to this disease. The research focuses on the intricate dance between insulin and the hormone amylin, or human islet amyloid polypeptide (hiAPP). Amylin is a naturally occurring peptide hormone that plays a role in regulating glycemia and energy balance. But...
|
|
|
Calcium, zinc intake tied to lower risk for hypertensive disorders of pregnancy
|
| |
Medical Xpress / HealthDay / NUTRITION 2024, the annual meeting of the Am. Society for Nutrition ^
| July 17, 2024 | Lori Solomon / Liping Lu, M.D., Ph.D.
People with higher intakes of calcium and zinc before pregnancy appear to have a significantly lower risk for hypertensive disorders of pregnancy (HDP), according to research. Liping
Lu, M.D., Ph.D. and colleagues used data from 7,737 pregnant women without chronic hypertension participating in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-To-Be to assess the association between preconceptional calcium intake (three months before pregnancy) and odds of HDP. There was a modest inverse association between energy density-adjusted calcium intake and HDP when adjusting for sociodemographic, lifestyle, clinical, and other dietary factors. The odds of HDP were 21 percent lower for participants in...
|
|
|
Higher calcium and zinc intake linked with healthier pregnancy outcomes
|
| |
Medical Xpress / NUTRITION 2024, the annual meeting of the American Society for Nutrition ^
| June 29, 2024 | Liping Lu, MD, Ph.D. et al
People with higher intakes of calcium and zinc in the three months before they conceived were significantly less likely to suffer hypertensive disorders during their pregnancy compared with those who had lower intakes of these essential minerals, according to new research. Hypertension,
or high blood pressure, is one of the most common disorders of pregnancy and can harm both the pregnant person and the developing fetus. Considering the potential adverse effects of antihypertensive medications during pregnancy, researchers have focused on opportunities to prevent dangerous hypertension-related disorders such as pre-eclampsia through modifiable factors like nutrition. The researchers conducted two separate studies...
|
|
|
Can You Hear Me Now? If Not, Zinc May Be Why
|
| |
American Council on Science and Health ^
| February 14, 2024 | Chuck Dinerstein, MD, MBA
Hearing loss, frequently due to exposure to loud noises, is a significant health problem. Its
biological underpinning may well be due to what we consider a trace mineral: zinc. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ How do we hear? Sound waves, really variations in air pressure, are collected and directed towards the eardrum by our outer ear, where we hang our glasses and the ear canal. Those waves strike the eardrum (tympanic membrane), transmitting those vibrations to the three small bones of the middle ear - the malleus (hammer), incus (anvil), and stapes (stirrup). The mechanical linkage of the three amplifies the incoming vibrations and...
|
|
|
Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism
|
| |
The Journal of Physiological Sciences ^
| 9/30/2017 (old-ish) | Olechnowicz et al
Poster's Note: This is a very long article documenting how zinc is Anti: Weight, diabetes, cholesterol, inflammation, oxidation, metabolic syndrome, stroke, atherosclerosis, death, high blood pressure, high blood sugar, cytokines, liver damage, blood vessel damage, kidney damage, etc. I'll
post the first dozen paragraphs or so, and you're welcome to follow the link to the extensive article. ------------- A number of studies have reported that zinc plays a substantial role in the development of metabolic syndrome, taking part in the regulation of cytokine expression, suppressing inflammation, and is also required to activate antioxidant enzymes that scavenge reactive oxygen species, reducing...
|
|
|
Scientists reveal mechanistic link between zinc levels and diabetes (Zinc helps fatty liver and diabetes)
|
| |
Medical Xpress / eLife ^
| Sept. 25, 2023 | Shek Man Chim et al
Researchers have identified a mechanistic link between zinc levels in humans and the risk of type 2 diabetes and fatty liver disease. Converging
lines of evidence have shown that zinc plays a crucial role in insulin production and glucose metabolism. "We know that increasing zinc intake improves blood glucose control in people with prediabetes or type 2 diabetes, and people with a mutation in a key zinc transporter protein have reduced risk of diabetes." says Shek Man Chim. Chim and colleagues identified a mutation called SLC39A5, associated with increased circulating zinc levels. The team explored its function by genetically engineering...
|
|
|
Researchers show zinc plays a key role in inflammatory bowel disease and 'leaky gut' (Zinc + Broccoli (indole-3-carbinol) found to reverse it)
|
| |
Medical Xpress / King's College London / Nature Communications ^
| Sept. 7, 2023 | Xiuchuan Hu et al
New research has found a link between the important micronutrient zinc and a sensor protein in the gut in the prevention and management of a range of bowel conditions, such as inflammatory bowel disease (IBD). Professor Christer Hogstrand investigated the role of zinc and a sensor named the Aryl Hydrocarbon Receptor (AHR)
that helps the body react to nutrients, drugs and toxic substances in the bowel. Mice fed a diet containing zinc and a chemical from cruciferous vegetables—such as broccoli—that stimulates the AHR were almost completely alleviated of IBD. In contrast, mice fed a zinc-deficient diet received no benefit from...
|
|
|
Hospital Superbugs Can Be Brought Under Control by a Surprise Weapon – Zinc
|
| |
Mirror ^
| 13 Apr 2023 | Miriam Stoppard
X-ray research leads to surprise find - zinc affects the stability of cells in superbug and removing it kills them, writes Dr Miriam StoppardYou might remember zinc best as zinc oxide, the thick white cream slathered on babies with nappy rash and used for burns, cuts and scrapes. It’s
a good barrier cream to protect the skin. But internally, zinc serves useful functions too – one of which is helping the production of healthy sperm. That’s because it promotes cell growth and multiplication, and supports the immune system. Now, exciting research from Warwick University is pointing the way to...
|
|
|
Antibiotics for acne: Study shows why one works best (Zinc and/or sarecycline are helpful)
|
| |
Medical Xpress / Yale University / Nucleic Acids Research ^
| March 8, 2023 | Isabella Backman / Ivan B Lomakin et al
A new study brings precision to the understanding of which antibiotics work best for acne treatment and why. This
is important for two key reasons. Acne affects nearly everyone at some point in life—it is, in fact, the eighth most common disease for all humans, affecting more than 85% of adolescents and young adults. And second, because antibiotics have long been an important go-to treatment for acne, dermatologists write more antibiotic prescriptions than any other specialty in medicine. Broad-spectrum antibiotics do not distinguish between good and bad bacteria, so they try to inhibit them all. In contrast, narrow-spectrum antibiotics target...
|
|
|
About half of patients with inflammatory bowel disease have zinc deficiency
|
| |
Medical Xpress / HealthDay / Nutrients ^
| Oct. 21, 2022 | Roberta Zupo et al
The prevalence of zinc deficiency is about 50 percent in inflammatory bowel disease (IBD) and is higher in patients with Crohn disease (CD) than those with ulcerative colitis (UC), according to a study. Roberta
Zupo and colleagues conducted a systematic review and meta-analysis to examine the prevalence of zinc deficiency in IBD. Nine articles met the inclusion criteria, which included 17 prevalence entries for CD and UC (nine and eight, respectively). The researchers found that across selected studies, the prevalence of zinc deficiency showed higher values in CD than in UC. In pooled analyses, the overall mean zinc deficiency prevalence...
|
|
|
Zinc enhances albumin's protective role against Parkinson's disease (Extra zinc and alpha lipoic acid help)
|
| |
Medical Xpress / King Abdullah Univ. of Sci. and Tech. / Intl. Jrnl. of Biological Macromolecules ^
| Oct. 17, 2022 | Samah Al-Harthi et al
Revealing zinc's interaction with a critical transport protein underscores the need to study biological pathways under physiologically relevant conditions. Heavy
metals in the body have long been thought to induce the aggregation of disease-linked proteins, but a study shows this is not always the case. It turns out that zinc ions tune the ability of human serum albumin (HSA), an abundant transport protein in the body, to better prevent α-synuclein from aggregating, a process directly linked to Parkinson's disease. The finding should "open new avenues for preventive treatments," says Samah Al-Harthi, a Ph.D. student. The unexpected role for zinc discovered...
|
|
|
Zinc could treat a rare genetic disorder (Pediatric encephalopathy)
|
| |
Medical Xpress / University of Geneva / Science Advances ^
| Oct. 10, 2022 | Yonika A. Larasati et al
Pediatric encephalopathies of genetic origin cause severe motor and intellectual disabilities from birth. One
of these diseases is caused by mutations in the GNAO1 gene. In order to understand the finer details of the resulting disturbances, scientists conducted atomic, molecular and cellular analyses. They discovered a mutation leads to the replacement of one amino acid by another in protein sequence. This is enough to disrupt the activation and deactivation mechanism of the encoded protein, thereby altering the ability of neurons to communicate correctly with their environment. A simple zinc molecule, commonly used in other contexts, could restore, at least partially,...
|
|
|
Russia Is Readying the Zinc Coffins Again: U.S. officials believe Russia is facing its toughest fight since World War II.
|
| |
Foreign Policy ^
| 8 August 2022 | Jack Detsch
The U.S. Defense Department believes that as many as 80,000 Russian troops have been killed or wounded since the Kremlin’s full-scale invasion of Ukraine less than six months ago, a top Pentagon official told reporters today... The United States has now provided nearly $10 billion in military aid to Ukraine since Russia’s
full-scale invasion, nearly twice Kyiv’s military budget in 2021... The Pentagon initially estimated that Russia deployed about 120 battalion tactical groups, the Kremlin’s go-to combined arms unit, for the war—numbering around 100,000 troops. Experts said the new casualty estimate is likely to include Russian paramilitary and volunteer forces,...
|
|
|
Metals found in people's urine could detect acute kidney injury in very early stages, says new study (Copper and zinc in simple urine tests indicates how bad serum creatinine could be 24 hours later (kidney damage))
|
| |
Medical Xpress / University of Nottingham / Kidney International Reports ^
| May 30, 2022 | Charlotte Anscombe / David S. Gardner et al
Scientists have discovered that certain metals found in people's urine, could be potentially useful clinical biomarkers for the early detection of acute kidney injury (AKI). Acute Kidney Injury (AKI) is a rapid deterioration in kidney function over hours or days. It
is common, occurring in 10–20% of patients admitted to hospital and about 50% of patients admitted to intensive care. It is widely accepted by clinicians that one of the main ongoing problems in managing AKI is the inability to detect it at a very early stage. Currently AKI is defined by a rise in a blood test, serum creatinine,...
|
|
|
A diet rich in protein, zinc and niacin and low in saturated fat makes blood vessels more flexible, research suggests (Reverse damaging cardio aging from food alone)
|
| |
Medical Xpress / European Association for the Study of Obesity / European Congress on Obesity (ECO) ^
| May 4, 2022 | Dr. Brurya Tal et al
A study has linked key nutrients, including protein, zinc and niacin, to improvements in heart health. Improvements
in metabolic and cardiovascular health seen during weight loss in people with obesity are traditionally attributed to either the weight loss itself or the accompanying changes in glucose, blood pressure or blood fats. Participants with metabolic syndrome and obesity (55.5% male, average age 53 years) were enrolled in a one-year intensive multidisciplinary weight loss program. Arterial wall stiffening is linked to a heightened risk of cardiovascular morbidity and mortality and so blood vessel flexibility was used as a proxy for cardiovascular health. Three...
|
|
|
New Book Packed With Evidence on Hushed COVID-19 Treatments: Recent studies confirm effectiveness of treatments like zinc, ivermectin
|
| |
Epoch Times ^
| 04/30/2022 | Kristen Fischer
Recent developments in treating COVID-19, especially in terms of existing therapeutics, are validating what doctors like Colleen Huber knew all along: masks, distancing, ventilators, and vaccines couldn’t resolve the COVID-19 pandemic. Last
year, Huber, a naturopathic medical doctor based in Arizona, published “The Defeat of COVID: 500+ Medical Studies Show What Works & What Doesn’t.” The book details research on COVID-19 treatments and strategies—everything from zinc and hydroxychloroquine to social distancing and masking. She shares studies that explore the effectiveness of the various treatments, preventative measures, and interventions.The book pays homage to doctors who have tried to promote early treatment...
|
|
|
Common dietary supplements could protect against COVID, common winter illnesses (Zinc picolinate, Taxifolin, and EGCG together provided most free zinc - up to 95% reduction in RNA viruses)
|
| |
Medical Xpress / Tel Aviv University / Pharmaceuticals ^
| Apr. 13, 2022 | Topaz Kreiser et al
Could dietary supplements become a healthy weapon against COVID-19? Experts have shown that common dietary supplements can protect against the coronavirus as well as several common winter illnesses. Prof.
Gazit, who also heads TAU's Blavatnik Center for Drug Discovery, said: "To address the rapid changes of the virus, we decided to develop active vaccines made of safe and easily obtainable dietary supplements that would reduce the viral load in the body and cut down contagion. We have known for years that food supplements containing zinc can enhance immunity to severe, viral and chronic infections and their potentially grave consequences." The...
|
|
|
Zinc deficiency may play a role in high blood pressure (Adequate zinc is needed to help kidneys filter out sodium, reducing blood pressure)
|
| |
Medical Xpress / American Physiological Society / American Journal of Physiology-Renal Physiology ^
| Jan. 24, 2019 | Clintoria R. Williams et al
Lower-than-normal zinc levels may contribute to high blood pressure (hypertension) by altering the way the kidneys handle sodium. The
study is published ahead of print in the American Journal of Physiology—Renal Physiology. Zinc deficiency is common in people with chronic illnesses such as type 2 diabetes and chronic kidney disease. People with low zinc levels are also at a higher risk for hypertension. The way in which the kidneys either excrete sodium into the urine or reabsorb it into the body—specifically through a pathway called the sodium chloride cotransporter (NCC)—also plays a role in blood pressure control. Less sodium in...
|
|
|
In mice, zinc improves regeneration of key immune organ and immune-cell recovery after bone marrow transplant
|
| |
Medical Xpress / Fred Hutchinson Cancer Research Center / Blood / Leukemia Research ^
| Mar. 31, 2022 | Sabrina Richards / Lorenzo Iovino et al
Zinc's immune-boosting properties are well-established, but we're still untangling how it works. The
team discovered that zinc is required for development of a specialized type of immune cell and prompts a critical immune organ to regenerate after damage. People whose zinc levels are too low have little to no infection-fighting T cells and the thymus, the organ in which T cells develop, is nearly non-existent, Iovino said. When zinc-deficient people are given extra zinc, their thymuses grow and start pumping out these immune cells. The thymus is quite delicate. Many stressors cause it to shrink and its T-cell production to...
|
|
|
Can correcting micronutrient deficiencies help treat heart failure? (Yes: Iron, selenium, zinc, copper, and Co-Q10)
|
| |
Medical Xpress / Journal of Internal Medicine ^
| Nov. 9, 2022 | Nils Bomer, Ph.D. et al
A review published in the Journal of Internal Medicine provides convincing evidence that micronutrients—including iron, selenium, zinc, copper, and coenzyme Q10—can impact the function of cardiac cells' energy-producing mitochondria to contribute to heart failure. The
findings suggest that micronutrient supplementation could represent an effective treatment for heart failure. "Micronutrient deficiency has a high impact on mitochondrial energy production and should be considered an additional factor in the heart failure equation, moving our view of the failing heart away from "an engine out of fuel" to "a defective engine on a path to self-destruction," said co–lead author Nils Bomer, Ph.D., of...
|
|
Click to show more articles ...
|
|
|
