Metals found in people's urine could detect acute kidney injury in very early stages, says new study (Copper and zinc in simple urine tests indicates how bad serum creatinine could be 24 hours later (kidney damage))

Medical Xpress / University of Nottingham / Kidney International Reports ^ | May 30, 2022 | Charlotte Anscombe / David S. Gardner et al

[ConservativeMind]

Scientists have discovered that certain metals found in people's urine, could be potentially useful clinical biomarkers for the early detection of acute kidney injury (AKI).

Acute Kidney Injury (AKI) is a rapid deterioration in kidney function over hours or days. It is common, occurring in 10–20% of patients admitted to hospital and about 50% of patients admitted to intensive care.

It is widely accepted by clinicians that one of the main ongoing problems in managing AKI is the inability to detect it at a very early stage.

Currently AKI is defined by a rise in a blood test, serum creatinine, or by a fall in urine output. These detection methods can take over 24 hours from the time of kidney damage to reveal a problem, by which time the disease process might be more difficult to manage.

…Using this model, they identified that certain urinary metals could be potentially useful clinical biomarkers for early detection of AKI.

Experts tested their hypothesis in two clinical groups at risk for developing AKI. They found that concentrations of the metals rose in urine from AKI patients within an hour after cardiac surgery, and were elevated on admission in ICU patients.

The biomarkers alone, or in combination (e.g. the product of Zn × Cu), had good sensitivity for early identification of patients at risk of moderate to severe AKI and particularly high negative predictive value, suggesting additional efficacy in identifying patients at low risk of AKI.

Urinary Cd, Cu and Zn fulfill most desirable characteristics of biomarkers and offer clinical and economic advantages over other reported AKI biomarkers. They are unaffected by comorbidity, proteinuria, sex or age.

Measurement of the metals is amenable to point-of-care testing using cheap screen-printed electrodes and are likely to be far more cost-effective than protein assays.

[ConservativeMind]

This is a set of tests your doctor can run today to estimate acute kidney injury.

[ConservativeMind]

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[Pelham]

AKI was the final stage of a progressively severe case of Covid that killed a friend of mine.

[Getready]

What if the patient is taking mineral supplements with those metals (except cadmium....a known nephrotoxic agent)

[Secret Agent Man]

They list cadmium in there

No one takes that, its a toxic contaminant, its a poison

Anyone who has any detectable levels of it in urine is in serious overall trouble, not just kidney trouble