I’ve found that when Adobe tries to update itself, it tries to import Chrome of some sort. When this happened my one-touch click on hyperlinks from Outlook or Outlook Express disappeared and some other funky file relate clicking stuff happened. It also affected double clicking on XLS spreadsheets. It wasn’t related to IE in any way.
I had to go each time (until I learned it was Adobe sabotaging me with Chrome) to MS and find the cleaner utility for it.
There IS a reason this Google crap is so pervasive and persistent.