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I’ve found that when Adobe tries to update itself, it tries to import Chrome of some sort. When this happened my one-touch click on hyperlinks from Outlook or Outlook Express disappeared

When you install Chrome it changes the registry entry to open Outlook hyperlinks with Chrome. The Chrome uninstall doesn't revert this change leaving Outlook hyperlinks broken.

This is only the tip of Chrome's evil iceberg.

[Gaffer]

Thanks!