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Moderna CMV Vaccine: Investing in Latent Virus Prevention
Contagion Live ^ | May 12, 2022 | John Parkinson

Posted on 11/12/2022 10:18:51 AM PST by vrwc1

Cytomegalovirus (CMV) is a common latent virus with over half of Americans infected with it by the age of 40, according to the Centers for Disease Control and Prevention (CDC).1 CMV typically lays dormant in people who do not have compromised immune systems.

For those who are beset with the active virus, they can have more serious symptoms affecting various parts of the body including the eyes, lungs, liver, esophagus, stomach, and intestines. And for babies born with CMV, they can have brain, liver, spleen, lung, and growth issues. Hearing loss is the most common problem in this patient group who are dealing with congenital CMV infection.1

“CMV is the leading infectious cause of birth defects in the United States,” Sandeep Basnet, MD, director, Clinical Development at Moderna.

Clinicians and researchers argue there is a strong need for preventative or treatment modalities for latent viruses such as CMV.

“CMV represents a significant unmet medical need right now,” Basnet explained. “…It can lead to lifelong medical conditions for those with weakened medical conditions or those born with CMV infection.”

There is no FDA approved vaccine to prevent CMV.

During its Vaccines Day back in March, Moderna discussed its commitment to addressing latent viruses and the company’s pipeline includes vaccines for Herpes Simplex Virus-1, Herpes Simplex Virus-2, Varicella zoster virus, Epstein-Barr Virus, and CMV. The company is applying its mRNA technology it used against COVID-19 to develop vaccines for latent viruses. Their CMV investigational vaccine, mRNA-1647, is in its phase 3 registration study, known as CMVictory.

The study is evaluating the safety and efficacy of mRNA-1647 against primary CMV infection in women ages 16-40 years. Moderna is looking to enroll up to 6900 women of child-bearing age, at approximately 150 sites globally, starting with the US. The company has set a goal of enrolling 42% of the participants as persons of color.

The vaccine combines 6 mRNAs in one vaccine, which encode for two proteins located on the surface of CMV: five mRNAs encoding the subunits that form the membrane-bound pentamer complex and one mRNA encoding the full-length membrane-bound glycoprotein B (gB). Both the pentamer and gB are essential for CMV to infect barrier epithelial surfaces and gain access to the body, which is the first step in CMV infection. The mRNA-1647 vaccine is designed to produce an immune response against both the pentamer and gB for the prevention of CMV infection.

Contagion spoke with Basnet about the mRNA-1647 efficacy and safety profile thus far and the mRNA platform’s capability to address latent viral infections.

Reference

1.Cytomegalovirus (CMV) and Congenital CMV Infection. Centers for Disease Control and Prevention. Updated August 18, 2020. Accessed May 12, 2022. https://www.cdc.gov/cmv/overview.html


TOPICS: News/Current Events
KEYWORDS: cmv; moderna; mrna; vaccines; virus
Another gene-therapy shot masquerading as a "vaccine" incoming, this one with 6 mRNAs in one shot.
1 posted on 11/12/2022 10:18:51 AM PST by vrwc1
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To: vrwc1

You’d have to be an idiot to take any of these insufficiently tested mRNA therapies.


2 posted on 11/12/2022 10:34:31 AM PST by jimwatx
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To: vrwc1

Now that they have destroyed humans’ immune systems they are going to shoot you up with more mRNA fixes for the latent viruses that the immune system would otherwise have kept in check. They will keep experimenting until they kill the golden goose.


3 posted on 11/12/2022 10:34:33 AM PST by iontheball
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To: vrwc1

It’s sad when the trust is gone. It’s gone.


4 posted on 11/12/2022 10:46:07 AM PST by small farm girl (....)
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To: vrwc1

Our “betters” are hoping to stumble upon the fountain of youth, while reducing
the annoying lab rat population (us) and getting richer. 6 mrna flavors in one
dose is an efficient shotgun approach, and they seem to still have willing lab rats
to expend.


5 posted on 11/12/2022 10:48:26 AM PST by EasySt (Say not this is the truth, but so it seems to me to be, as I see this thing I think I see. #MAGAA)
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To: vrwc1

Every new vaccine is going to be mRNA. I just saw they unleashed an RNA flu shot this year too.


6 posted on 11/12/2022 10:51:16 AM PST by DesertRhino (Dogs are called man's best friend. Moslems hate dogs. Add it up..)
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To: vrwc1

What idiot would believe another story from the “World Depopulation Gang”?


7 posted on 11/12/2022 10:58:00 AM PST by MtnClimber (For photos of Colorado scenery and wildlife, click on my screen name for my FR home page.)
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To: vrwc1

The idea is to reduce the population. They will now speed up the process and use ways other than covid.


8 posted on 11/12/2022 10:59:15 AM PST by dforest
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To: small farm girl

I just learned that a second vaccinated Aunt of mine has passed from a stoke
this morning, following months of complications after mRNA vaccination,

I have two vaccinated Uncles in trouble too. All of our unjabbed remain ok.

I wanted the reports of drastic increase in all cause mortality to be fake.

I didn’t get what I wanted.


9 posted on 11/12/2022 11:05:55 AM PST by EasySt (Say not this is the truth, but so it seems to me to be, as I see this thing I think I see. #MAGAA)
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To: MtnClimber

‘What idiot would believe another story from the “World Depopulation Gang”?’

When is this world depopulation going to start? Been hearing about it since the Covid vaccine came out.

In the U.S. we’re closing in on 650 million covid vaccine shots that have been given. Looks like we’d have dead piling up in the streets if the depopulation theories are true. No bodies piling up here in N.GA.


10 posted on 11/12/2022 11:29:50 AM PST by Roadrunner383 (;)
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To: EasySt

There over 380 TRILLION virus particles in the human body. They keep us alive. Sure, some of them are harmful, but most are beneficial. More than there are stars in our galazy.
https://www.inverse.com/article/49747-what-is-the-human-virome
What better way to thin the human herd than to get people to take a vaccine that kills us that way
You have over a million bacteria on each of your fingers. Exposure causes your body to build up immunity. Kids that were locked down didn’t develop immunity to the typical viruses and bacteria and are now getting sick


11 posted on 11/12/2022 11:34:46 AM PST by TStro (Better to die on your feet than live on your knees)
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To: Roadrunner383
I am on shot number zero. I hope you get the shot number that you want.


12 posted on 11/12/2022 11:36:16 AM PST by MtnClimber (For photos of Colorado scenery and wildlife, click on my screen name for my FR home page.)
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To: vrwc1

Y pediatrician told me to abort my third child because I had cmv antibodies in my blood test. My co worker had same OB gyn doctor. Told the same thing. Their names are amanda and Sabrina.


13 posted on 11/12/2022 12:19:33 PM PST by Donnafrflorida (Thru Him all things are possible.)
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To: Donnafrflorida

Your comment brightened my day.
Cheers.


14 posted on 11/12/2022 2:34:43 PM PST by Baldwin
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