Free Republic
Browse · Search
News/Activism
Topics · Post Article

Skip to comments.

Bacteria-immune system 'fight' can lead to chronic diseases, study suggests
Biology News Net ^ | August 2, 2012 | NA

Posted on 08/04/2012 7:16:59 PM PDT by neverdem

Results from a study conducted at Georgia State University suggest that a "fight" between bacteria normally living in the intestines and the immune system, kicked off by another type of bacteria, may be linked to two types of chronic disease.

The study suggests that the "fight" continues after the instigator bacteria have been cleared by the body, according to Andrew Gewirtz, professor of biology at the GSU Center for Inflammation, Immunity and Infection. That fight can result in metabolic syndrome, an important factor in obesity, or inflammatory bowel disease (IBD).

The results were published in the journal Cell Host & Microbe.

"The implication at present is that it is very important to control the early environment," Gewirtz said. "We need to examine how this can be achieved – perhaps via breastfeeding, a more diverse diet, probiotics are possibilities."

The study's results are important as instances of chronic diseases like metabolic syndrome and IBD are increasing rapidly among humans, he explained.

Metabolic syndrome involves risk factors, including obesity, which can lead to cardiovascular disease, diabetes and stroke. According to the American Heart Association, about 35 percent of adults are affected by this syndrome.

IBD, which includes Crohn's disease and ulcerative colitis, happens when the intestines become inflamed, leading to abdominal cramps and pain, diarrhea, weight loss and bleeding.

More than 600,000 Americans annually have some kind of inflammatory bowel disease, according to the American Academy of Family Physicians.

Bacteria normally live in the gut of humans, with the average human having about 4 pounds of bacteria living there.

"It is increasingly apparent that bacteria are playing a role in healthy development, and need to be properly managed by the mucosal immune system to avoid inflammatory diseases" Gewirtz explained. Source : Georgia State University


TOPICS: Culture/Society; News/Current Events; Testing
KEYWORDS: bacteria; health; healthmedicine; immunesystem; immunology; intestines; medicine; microbiology
Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice
1 posted on 08/04/2012 7:17:08 PM PDT by neverdem
[ Post Reply | Private Reply | View Replies]

To: neverdem

It is also a matter of scientific fact that both Obama and Romney and detrimental to good digestion in conservatives. Both are known to induce explosive bowel movements and projectile vomiting in the conservative population studied.


2 posted on 08/04/2012 7:26:29 PM PDT by Sola Veritas (Trying to speak truth - not always with the best grammar or spelling)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

See what you get for posting an interesting article?


3 posted on 08/04/2012 7:36:34 PM PDT by chessplayer
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

Ping for later


4 posted on 08/04/2012 7:49:29 PM PDT by Vinnie (A)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

Makes sense. I’ve noticed that chronic low-grade infections tend to have very similar symptoms, whether the infecting agent is a bacteria, virus, fungus, whatever. As one example, fibromyalgia has the same symptoms as both chronic Lyme’s disease, and certain types of mold exposure, to the point where they are all easily mistaken for one another. Sometimes I really wish I was a research scientist, because I’d love to pursue that lead.


5 posted on 08/04/2012 8:09:51 PM PDT by Ellendra ("It's astounding how often people mistake their own stupidity for a lack of fairness." --Thunt)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Ellendra
The answer . . prayer and non colloidal SILVER SOL. . .liquid 10ppm, 22ppm, and 24ppm GEL. No one should be without it. Great for animals, too. Do a search for Dr. Pedersen. . . shop around for the best prices. Over 90 uses including Lyme's, fibromyalgia, mold, MRSA, Crohn's. Speaking from personal experience (family and friends).
6 posted on 08/04/2012 11:15:18 PM PDT by Maudeen (Proverbs 3:5-6)
[ Post Reply | Private Reply | To 5 | View Replies]

To: afnamvet

Ping


7 posted on 08/05/2012 1:01:57 AM PDT by neverdem (Xin loi minh oi)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; Battle Axe; null and void; ...
What Makes Bat Viruses So Deadly?

FReepmail me if you want on or off my combined microbiology/immunology ping list.

8 posted on 08/05/2012 1:11:18 AM PDT by neverdem (Xin loi minh oi)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem
Has there been any study or studies that have established that a change in gut flora causes, rather than results from, one of those metabolic diseases?

Everything I've read so far on the subject has documented a correlation between gut flora and certain diseases, but I've yet to see any causative relationship established either way. The journal article referenced in this article isn't indexed at PubMed yet, so I can't read it. However, I question whether the response of TLR5 knockout mice to infection is relevant to the question of which comes first, the gut flora or the inflammatory condition.

9 posted on 08/05/2012 4:46:49 AM PDT by exDemMom (Now that I've finally accepted that I'm living a bad hair life, I'm more at peace with the world.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Maudeen
Details, please, especially with respect to (OK, DISrespect to, as we are trying to kill them) molds?

Cheers!

10 posted on 08/05/2012 6:52:37 AM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change without notice.)
[ Post Reply | Private Reply | To 6 | View Replies]

To: grey_whiskers

I typed in silver sol and mold and found this

I’ve seen the info several other places. Check also on he right on this link for other uses for it.

http://www.silversolsolution.com/black-mold/

I don’t know what we would have done without silver sol for my elderly parents. I’d have some on hand for emergencies especially. This is NOT your usual colloidal silver! I read where a baby could ingest a whole tube of it and not be affected.


11 posted on 08/05/2012 9:26:15 AM PDT by Maudeen (Proverbs 3:5-6)
[ Post Reply | Private Reply | To 10 | View Replies]

To: Maudeen

I’ve seen too many contradictory studies on colloidal silver to put much faith in it.


12 posted on 08/05/2012 9:42:21 AM PDT by Ellendra ("It's astounding how often people mistake their own stupidity for a lack of fairness." --Thunt)
[ Post Reply | Private Reply | To 6 | View Replies]

To: neverdem
Dr. Hibbert: "So you can see you have every disease, and a few we've never really seen. They've reached a sort of symbiance and are balanced in such a way that it isn't affecting you. ha ha ha."
Mr. Burns: "So what you're saying is I'm invincible?"
Dr. Hibbert: "Oh dear God no, the slightest breeze could kill y..."
Mr. Burns: "Invincible..."


13 posted on 08/05/2012 9:54:17 AM PDT by Lancey Howard
[ Post Reply | Private Reply | To 1 | View Replies]

To: Ellendra; Maudeen

“...too many contradictory studies on colloidal silver...”

Yes, there are many contradictory studies because of the agenda of some doing studies...there is nothing contradictory about the results gleaned from using colloidal silver. Also, some of the studies have used ionic silver, not colloidal silver...big difference. Some years ago researchers, when dimes were real silver, would put a dime in a petri dish to steralize it in the lab. The many benefits of silver predate antibiotics, predate modern medicine. And bacteria, virus, mold does cannot develop a resistance to it.

A colloid is a substance of ultramicroscopic particles. Colloidal silver is nothing more than very tiny particles of pure silver suspended in distilled water through the process of electrolysis. The smaller the particles in CS the better the body can assimilate them. When current is applied to silver in solution the particles that break off will always be the same size: 1.26 angstroms (.000126 microns). This is so small that its nearest rival is an atom. Colloidal silver is odorless, tasteless and has no known negative reaction to any medication, health problem, diet, or artificial alteration to the human body. It is considered to be Creator God’s natural antibiotic provided for the good health of the people of planet Earth.

Silver has been known to be a bactericide for at least 1200 years. Even in ancient times, it was known to prevent disease, and it was said that disease could not be transmitted in drinking from a silver cup. Silver coins were commonly dropped into a jar to prevent the spoilage of milk and other drink, and silver containers were used to prolong the freshness of foods in general.

UCLA ran some tests on Colloidal Silver and their report states: “The silver solutions were antibacterial for Streptococcus pyogenes, Staphylococcus aureus, Neisseria gonorrhea, Gardnerella Vaginalis, Salmonella Typhi, and other enteric pathogens, fungicidal for Candida albicans, Candida globata, and M. furfur, and it killed every virus that was tested in the lab”.
Other voices in the medical community are saying…
Dr. Hirschberg, John Hopkins: “...remarkable for their beneficial action in infective states”.
Dr. Henry Cooks: “I know of no microbe that is not killed in laboratory tests within six minutes”.
Dr. Gary Smith: “When silver was present the cancer cell was de-differentiated and the body was restored”.

I hope, Ellendra, you do not find this info too contradictory...


14 posted on 08/05/2012 10:11:40 AM PDT by GGpaX4DumpedTea (I am a Tea Party descendant...steeped in the Constitutional Republic given to us by the Founders.)
[ Post Reply | Private Reply | To 12 | View Replies]

To: Ellendra

This is not colloidal silver. It helped my sister’s Crohn’s, my mother’s MRSA, a friend of my sister’s husband who was literally dying after infected sutures. Put the gel on and they said it looked like a volcano erupting. He also ingested the liquid. A few months later he went back to the doctor and there was absolutely NO scarring. The doctor was amazed and wondered what he did. My beagle was mauled and on his deathbed. The vets sewed him up. I decided to use the gel rather than the ointment they gave. No indication of a wound now. The vet a year later couldn’t believe it was the same dog. . . . .the stories go on and on. If stock were available, I would buy it.


15 posted on 08/05/2012 11:09:53 AM PDT by Maudeen (Proverbs 3:5-6)
[ Post Reply | Private Reply | To 12 | View Replies]

To: 2ndreconmarine; Fitzcarraldo; Covenantor; Mother Abigail; EBH; Dog Gone; ...

Ping... (Thanks, neverdem!)


16 posted on 08/05/2012 11:42:15 AM PDT by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing)
[ Post Reply | Private Reply | To 1 | View Replies]

To: exDemMom
Has there been any study or studies that have established that a change in gut flora causes, rather than results from, one of those metabolic diseases?

Everything I've read so far on the subject has documented a correlation between gut flora and certain diseases, but I've yet to see any causative relationship established either way.

It's an interesting dilemma, but it's probably unethical to test the hypothesis directly, i.e. infect naive humans with H. Pylori to see if they subsequently develop metabolic syndrome or type 2 diabetes.

I think you can test it indirectly by testing type 2 diabetics for H. Pylori antibodies and treating those who are positive for it. The National Health and Nutrition Examination Surveys found a correlation between H. Pylori antibodies and elevated hemoglobin A1c. That would be another population for treatment of a presumptive H.Pylori in a double blind trial. If that resolves type 2 diabetes or prediabetic hyperglycemia, that speaks for itself. If I had my druthers, I'd test those responding to H. pylori treatment with normal blood glucose levels for any common defects in their innate or acquired immune systems.

The journal article referenced in this article isn't indexed at PubMed yet, so I can't read it.

I found the link in comment# 1 by going to the named journal, Cell Host & Microbe. It's a method I had to use after the updated PubMed couldn't support my old computer. I usually check the author's surname on the journal's homepage and in their advance online publication or equivalent link.

However, I question whether the response of TLR5 knockout mice to infection is relevant to the question of which comes first, the gut flora or the inflammatory condition.

That's not unreasonable, but I'd like to rule out defects in the innate immune system, e.g. Toll-like receptors and diabetes: a therapeutic perspective.

Association between gastric Helicobacter pylori colonization and glycated hemoglobin levels.

Helicobacter pylori infection is associated with an increased rate of diabetes.

17 posted on 08/05/2012 12:46:21 PM PDT by neverdem (Xin loi minh oi)
[ Post Reply | Private Reply | To 9 | View Replies]

To: neverdem

After centuries of anecdotal experience, scientists have finally figured out why common peppermint is an effective counter to many cases of IBD.

There are intestinal cells that become chronically inflamed, which creates a vicious circle keeping them inflamed. But peppermint soothes these cells which allows the system to normalize.

Just drinking a teaspoon full of natural peppermint extract added to a glass of water, once or twice a day, after a week or two is effective for many people in breaking their IBD cycle.

The scientists noted that some foods and are known to irritate these cells, like hot pepper, mustard, caffeine, acidic foods, and fruits in *some* people, as well as those that create a mild allergic response in particular people.


18 posted on 08/05/2012 1:04:19 PM PDT by yefragetuwrabrumuy
[ Post Reply | Private Reply | To 1 | View Replies]

To: Mars

bfl


19 posted on 08/05/2012 2:26:54 PM PDT by Mears
[ Post Reply | Private Reply | To 6 | View Replies]

To: neverdem

bm


20 posted on 08/05/2012 2:37:04 PM PDT by rurgan (Sunset all laws at 4 years.China is destroying U.S. ability to manufacture,makes everything)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem
It's an interesting dilemma, but it's probably unethical to test the hypothesis directly, i.e. infect naive humans with H. Pylori to see if they subsequently develop metabolic syndrome or type 2 diabetes.

I'd stick with cell culture studies or animals as a last resort. There are plenty of methods of testing these questions that don't involve clinical studies with human subjects. (I dislike clinical human studies anyway; I find them extremely limited in the types of questions that they can answer, and often they are flawed in other ways.)

I was able to find the abstract directly at the journal website. The full abstract, at least, seems to recognize that there is a more complicated two-way interaction between host and flora than the article posted here would indicate. Still, this article makes claims that are not, as far as I can tell, supported by the evidence--for example, the claim that it may be important to control the early environment to prevent conditions such as metabolic syndrome leading to obesity. I think that, to a large extent, the metabolic conditions cause the change in microflora. Since an obese person's biochemistry is not the same as a thin person's biochemistry, I would expect to see a difference in species prevalence of gut microflora as a result.

21 posted on 08/05/2012 5:21:23 PM PDT by exDemMom (Now that I've finally accepted that I'm living a bad hair life, I'm more at peace with the world.)
[ Post Reply | Private Reply | To 17 | View Replies]

To: GGpaX4DumpedTea
there is nothing contradictory about the results gleaned from using colloidal silver.

Unless you count the people who died from it.

Some years ago researchers, when dimes were real silver, would put a dime in a petri dish to steralize it in the lab.

The toxic effects that silver has on single-celled organisms is well documented. However, the question is whether it is similarly toxic to multi-cellular organisms. Unfortunately, there are too many studies that say yes, it is. It just takes a higher dosage (as with all poisons), but because it builds up in body tissues, continuing to take it will, eventually, result in silver poisoning. The body treats it as a heavy metal. Which, chemically speaking, it is. Most non-metal based antibiotics don't build up in the tissues.

I hope, Ellendra, you do not find this info too contradictory...

What, just because you only quoted sources that backed you up, and dismissed all others as having an "agenda", in spite of the fact that ALL studies have an agenda, including the ones that agree with you?
22 posted on 08/05/2012 8:50:50 PM PDT by Ellendra ("It's astounding how often people mistake their own stupidity for a lack of fairness." --Thunt)
[ Post Reply | Private Reply | To 14 | View Replies]

To: Maudeen

The use of silver in wound dressings does show promise, but given the way silver builds up in body tissues until it reaches toxic levels, I’ll pass on the injested kind, thank you. I’ve been through chelation for metal poisoning once already, and that was more than enough.


23 posted on 08/05/2012 8:55:51 PM PDT by Ellendra ("It's astounding how often people mistake their own stupidity for a lack of fairness." --Thunt)
[ Post Reply | Private Reply | To 15 | View Replies]

To: Smokin' Joe

Thanks for the ping!


24 posted on 08/05/2012 9:02:22 PM PDT by Alamo-Girl
[ Post Reply | Private Reply | To 16 | View Replies]

To: Ellendra

“Unless you count the people who died from it.”

Sources, please.

“However, the question is whether it is similarly toxic to multi-cellular organisms. Unfortunately, there are too many studies that say yes, it is.”

Sources, please.

“Most non-metal based antibiotics don’t build up in the tissues.”

And they do not work. MRSA, C-DIFF, etc etc etc...these are because of the over use of antibiotics by doctors...and these hospital acquired diseases kill people. There are solutions to these too, but not in the conventional medicine scheme of things.


25 posted on 08/05/2012 9:15:43 PM PDT by GGpaX4DumpedTea (I am a Tea Party descendant...steeped in the Constitutional Republic given to us by the Founders.)
[ Post Reply | Private Reply | To 22 | View Replies]

To: exDemMom
I think that, to a large extent, the metabolic conditions cause the change in microflora. Since an obese person's biochemistry is not the same as a thin person's biochemistry, I would expect to see a difference in species prevalence of gut microflora as a result.

Pregnancy alters resident gut microbes

Good hunch, but neither pregnant women nor diabetics are considered as having robust immune systems. In the former, it's considered down regulated. In the latter, it's compromised in ways similar to cancer patients, patients on chronic steroid therapy or chronic alcoholics, at least from a clinical perspective.

26 posted on 08/05/2012 9:28:27 PM PDT by neverdem (Xin loi minh oi)
[ Post Reply | Private Reply | To 21 | View Replies]

To: Ellendra

My hunch is that a lot of the vague “fatigue, depression, anxiety attacks, and chronic pain” symptoms women experience and often get diagnosed as fibromyalgia are due to improper sleep.

I was amazed to read that sleep has an amplifying effect on all of these symptoms, and these symptoms of course cause sleepiness in turn. Plus, there does seem to be a general consensus in society that women are inadequate if they can’t function on little sleep, because of the demands of motherhood.


27 posted on 08/05/2012 9:41:15 PM PDT by Cruising For Freedom
[ Post Reply | Private Reply | To 5 | View Replies]

To: Cruising For Freedom; Ellendra

ack... fat fingers... I meant SLEEPLESSNESS not sleepiness. Lack of sleep may be what causes those symptoms.


28 posted on 08/05/2012 9:42:35 PM PDT by Cruising For Freedom
[ Post Reply | Private Reply | To 27 | View Replies]

To: Ellendra

This is NOT that kind of silver. It leaves the body in 24 hours. This is not injected into anything (however, they are doing some IV processes) You need to read about it. Homeland security, special ops, etc. are using it. My sister’s friend has someone in the nursing home and the nurse said she was happy to see they were giving their loved one silver sol. Type in Dr. Pedersen and watch the videos. It healed a MRSA sore for my mother that amazed the doctor with no scar. I won’t bother you again with a post but I think you need to take a look at this stuff . . . it’s amazing and NOT like the regular silver that can collect in the body and even turn a person blue


29 posted on 08/05/2012 11:46:58 PM PDT by Maudeen (Proverbs 3:5-6)
[ Post Reply | Private Reply | To 23 | View Replies]

To: GGpaX4DumpedTea

Mirsattari SM, Hammond RR, Sharpe MD, Leung FY, Young GB (April 2004). “Myoclonic status epilepticus following repeated oral ingestion of colloidal silver”.

http://rais.ornl.gov/tox/profiles/silver_f_V1.html

http://www.drweil.com/drw/u/QAA363388/collodial-silver.html

http://cira.ornl.gov/documents/SILVER.pdf

http://www.cqs.com/silver.htm

Ellenhorn, M.J., S. Schonwald, G. Ordog, J. Wasserberger. Ellenhorn’s Medical Toxicology: Diagnosis and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams and Wilkins, 1997., p. 1608

http://nccam.nih.gov/health/silver

Let me know if you’d like to see more.

As a side note, it seems the increase in the use of silver in wound dressings and as an antibiotic is leading to new resistant strains of bacteria already:
http://www.nursingtimes.net/nursing-practice-clinical-research/bacterial-resistance-to-silver-based-antibiotics/201749.article

http://www.o-wm.com/article/8483


30 posted on 08/06/2012 12:01:36 AM PDT by Ellendra ("It's astounding how often people mistake their own stupidity for a lack of fairness." --Thunt)
[ Post Reply | Private Reply | To 25 | View Replies]

To: neverdem
Good hunch, but neither pregnant women nor diabetics are considered as having robust immune systems. In the former, it's considered down regulated. In the latter, it's compromised in ways similar to cancer patients, patients on chronic steroid therapy or chronic alcoholics, at least from a clinical perspective.

Of course.

My objection is more to the idea that these metabolic conditions can be treated by altering the gut flora, when it looks a lot like the microbial species distribution is a consequence of the conditions. The concept that, e.g., obesity could be cured by altering the gut microflora is very appealing, since there really is no easy way to treat or even prevent it, and it is human nature to want easy solutions. This isn't to say that certain microorganisms don't have an effect; clearly, a bacterial colonization of synovial fluid will cause problems.

31 posted on 08/06/2012 3:57:07 AM PDT by exDemMom (Now that I've finally accepted that I'm living a bad hair life, I'm more at peace with the world.)
[ Post Reply | Private Reply | To 26 | View Replies]

To: Ellendra

Thank you. I will check these out. I do know of some experience we and others have had with very high oral doses using colloidal silver and no adverse effects. I also know that if the silver is ionic rather tan colloidal, the results can be very negative.

Some doctors in Texas were using colloidal silver intravenously to treat Aids, and were having great success. The FDA shut down the supplier of the colloidal silver to stop this successful treatment.


32 posted on 08/06/2012 8:05:14 PM PDT by GGpaX4DumpedTea (I am a Tea Party descendant...steeped in the Constitutional Republic given to us by the Founders.)
[ Post Reply | Private Reply | To 30 | View Replies]

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
News/Activism
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson