It also seems to be a safe one.
How long before they makes these illegal?
Posted on 01/18/2008 2:39:53 PM PST by neverdem
The makers of antidepressants like Prozac and Paxil never published the results of about a third of the drug trials that they conducted to win government approval, misleading doctors and consumers about the drugs’ true effectiveness, a new analysis has found.
In published trials, about 60 percent of people taking the drugs report significant relief from depression, compared with roughly 40 percent of those on placebo pills. But when the less positive, unpublished trials are included, the advantage shrinks: the drugs outperform placebos, but by a modest margin, concludes the new report, which appears Thursday in The New England Journal of Medicine.
Previous research had found a similar bias toward reporting positive results for a variety of medications; and many researchers have questioned the reported effectiveness of antidepressants. But the new analysis, reviewing data from 74 trials involving 12 drugs, is the most thorough to date. And it documents a large difference: while 94 percent of the positive studies found their way into print, just 14 percent of those with disappointing or uncertain results did.
The finding is likely to inflame a continuing debate about how drug trial data is reported. In 2004, after revelations that negative findings from antidepressant trials had not been published, a group of leading journals agreed to stop publishing clinical trials that were not registered in a public database. Trade groups representing the world’s largest drug makers announced that members’ companies would begin to release more data from trials more quickly, on their own database, clinicalstudyresults.org.
And last year, Congress passed legislation that expanded the type of trials and the depth of information that must be submitted to clinicaltrials.gov, a public database operated by the National Library of Medicine. The Food and Drug Administration’s Web site provides limited access to recent reviews of drug trials...
(Excerpt) Read more at nytimes.com ...
If there was mischief with the trials, then that is bad. However, let’s not turn this into an “anti-depressants don’t really work” tirade. Believe me, they do.
Thank you.
I find this thread very depressing.
It also seems to be a safe one.
How long before they makes these illegal?
Anti-depressants don’t really work.
My own experience with Zoloft is that it took the edge off of the despair. There was a numbing effect, and say what you will about being numb but there are times of excruciating tragedy where you’re just trying to get through the day, and any lessening of your pain is welcome.
I dated a woman on anti-depressants for a year - Jeckel and Hyde and never again.
Anti-depressants work really well- till they stop working. I say this on every anti-depressant thread I come on, but don’t start (and, for heaven’s sake, certainly don’t STOP) any anti-depressant regimen without googling “ssri withdrawal” first. This is something doctors don’t mention that patients need to know about.
i've seen that sh!t up close and personal... my ex, my Boss and HIS BOSS were all on that sh!t in one form/dosage or another for tree years and if it wasn't for me... NOTHING would ever get done at home or at work. after three years i quit both. i love her dearly, but...
I’ve been running across a lot of people lately that I’m sure are on that stuff. Do they tend to become quite self-absorbed? And talk a LOT? And never seem to say much? And take FOREVER to tell a simple story? And do they lose quite a few IQ points? And they become boring?
I really want to know what you think.
in my ex, God love her, it's that she doesn't care about ANYTHING any more. she is great at her job with raises and promotions but soon as she leaves work it's "who cares..."
my boss/his boss are who cares at work, and yes they talk more sh!t than a little bit and it was amusing sometimes to see them get lost in their train of rant
or even better, was seeing the division head talking to me in a meeting one day while playing with some damn new toy he had on his desk and simply got lost into playing with the toy(one of these magnet toys) so i just let him play to see how long it would take but the secretary knocked on the door and snapped him out of it but it had been going on three minutes.
Miracle recovery of London man who was dead for an hour after 'drowning'
FReepmail me if you want on or off my health and science ping list.
Thanks for responding. I guess I’m seeing something different because “who cares” is not their attitude. I wish.
Thanks for the link.
Anything in the story about St. John’s Wort? :’) Thanks neverdem.
i'm sure there are many different manifestations, these are only my encounters.
“don’t STOP) any anti-depressant regimen without googling “ssri withdrawal” first. This is something doctors don’t mention that patients need to know about.”
This is so true. Had a relative who stopped without telling anyone and she took her own life and the life of her beloved dog.
Doc didn’t warn her and it is truly such a sad situation in our lives.
Three moths after she died, the FDA came out with its first warning on antidepressants.
ANYONE YOU KNOW ON THEM OR IF THEY ARE GETTING OFF THEM, PLEASE, PLEASE WATCH CAREFULLY.
Here are a few of the effects on withdrawal:
The withdrawal reaction which may be seen within 8-hours in some people (occasionally necessitating q.i.d. administration of paroxetine or venlafaxine) often includes:
anxiety
dizziness
fatigue
headache
insomnia
nausea
restlessness
tremors
visual hallucinations/illusions.
Here is a forum I have followed for years of people trying to get off effexor.
http://www.dr-bob.org/babble/20030417/msgs/221097.html
Thanks for the ping neverdem.
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