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Now, vision possible with ADULT stem cells
Indian Express Newspapers ^ | 11.12.06 | Khushboo Sandhu

Posted on 11/13/2006 9:28:13 PM PST by Coleus

“After every Diwali, a large number people are blinded while bursting fire crackers. There are others who suffer from blindness due to chemical burns. But there is a ray of hope for such patients,” said Dr Radhika Tandon, Additional Professor, Ophthalmology, All India Institute of Medical Sciences (AIIMS) at the national symposium on stem cells being held at Panjab University.

“Standard corneal transplant does not work in cases where blindness is due to chemical burning. But stem cell transplant can prove to be effective,” she said, adding that stem cell transplants do not ensure a perfect vision, but the patient can become self-dependent. “In case, the doctors feel that there is scope for further improvement, then corneal transplant can be done,” she said.

Cautioning that stem cells could not do magic, Dr Tandon said, “The treatment is expensive and requires follow-ups. The decision on whether to operate or not is a very sensitive one and stem cell transplant should be used only after assessing the benefits.” “In case one of the eyes is affected, then stem cells can be transferred from the healthy eye. But when both the eyes are affected, stem cells from a relative, mostly mothers, are taken. They can also be taken from a cadaver donor,” she said.

Dr Tandon said stems cells can be directly transferred and made to grow in the eye, but this can make the donor eye weak. The other method is to cultivate them in a laboratory and then transferred to the eye, she added. She, however, emphasised that prevention was the best method of protecting eyes. “No matter how hard we try we cannot match up to what God has given us naturally,” she said. Dr Tandon suggested that the government should invest in a few centres all over the country where stem cells can be cultivated.


TOPICS: Culture/Society
KEYWORDS: adultstemcells; blindness; cornea; india; ophthalmology; sight; stemcells; vision

1 posted on 11/13/2006 9:28:14 PM PST by Coleus
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To: 2ndMostConservativeBrdMember; afraidfortherepublic; Alas; al_c; american colleen; annalex; ...


2 posted on 11/13/2006 9:28:52 PM PST by Coleus (Roe v. Wade and Endangered Species Act both passed in 1973, Murder Babies/save trees, geese, algae)
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To: Coleus

Of course in pointing out that this is ADULT stem cell therapy, you will also point out that embryonic stem cell research is so new that it has not yet been approved for human trials... right?


3 posted on 11/13/2006 9:30:30 PM PST by Lunatic Fringe (Say "NO" to the Trans-Texas Corridor)
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To: Coleus

ssshhhhhhh.... nobody tell michael j fox or claire mcCaskill. we wouldn't want them to regret slandering anybody for 'not supporting stem cell research' or 'cures' for people with CNS diseases.


4 posted on 11/13/2006 9:31:09 PM PST by bpjam (Don't Blame Me. I Voted GOP.)
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To: Coleus

A good post. Adult Stem cells again show promise while embryonic ones create tumors. This isn't about politics folks it is about something that works versus something that doesn't. I'm surprised with some of these stem cell initiatives that the AIDs activists aren't trying the same thing yet. Get funding passed through referendum.


5 posted on 11/13/2006 9:31:09 PM PST by Maelstorm (Soldiers need our support, our courage, and our prayers. Not our second guessing and our cowardice.)
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To: Maelstorm

Health and Warfare are always politics these days.


6 posted on 11/13/2006 9:32:40 PM PST by MaxMax (God Bless America)
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To: Maelstorm
Adult Stem cells again show promise while embryonic ones create tumors.

You are not being totally truthful. Yes, ESC created tumors in mice when directly injected into them... but this is not what would be done in human treatments and it is not what is currently done in adult stem cell treatment.

7 posted on 11/13/2006 9:33:58 PM PST by Lunatic Fringe (Say "NO" to the Trans-Texas Corridor)
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To: Lunatic Fringe; Maelstorm

but this is not what would be done in human treatments and it is not what is currently done in adult stem cell treatment. >>>

oh, you know? please explain. In many of the articles I've posted it was reported that the researchers did inject adult stem cells into the patients. How else are the stem cells, embryonic or non-embryonic, introduced into the patient? In most cases they are grown in a culture and then injected into the area.


8 posted on 11/13/2006 9:42:51 PM PST by Coleus (Roe v. Wade and Endangered Species Act both passed in 1973, Murder Babies/save trees, geese, algae)
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To: Coleus

Thank you for both the posts on adult stem cell treatments.


9 posted on 11/13/2006 10:03:21 PM PST by Brad from Tennessee (Anything a politician gives you he has first stolen from you)
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To: Lunatic Fringe
"Yes, ESC created tumors in mice when directly injected into them... but this is not what would be done in human treatments and it is not what is currently done in adult stem cell treatment."

I have done a lot of reading on the subject of embryonic stem cells for the treatment of Parkinson's. I followed it because my wife has Parkinson's and I have researched all available treatments for the last 30 (yea... thirty) years.

They did some trials with ESC, and they were VERY unsuccessfully. The cells indeed reproduced in the subjects, and alleviated the PD symptoms, however they continued to grow and produce more and more dopamine until the patient was completely overdosed to the extent that they were worse off than before the procedure.

The problem with the embryonic cells is it seems, that they grow out of control. ie: tumors... they haven't found a way to turn the cell reproduction off.
10 posted on 11/13/2006 10:27:52 PM PST by babygene
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To: Coleus; Peach; airborne; Asphalt; Dr. Scarpetta; I'm ALL Right!; StAnDeliver; ovrtaxt; ...
Localization of candidate stem and progenitor cell markers within the human cornea, limbus, and bulbar conjunctiva in vivo and in cell culture.

Entered adult stem cells and blindness.

11 posted on 11/13/2006 11:35:42 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: neverdem

Bump


12 posted on 11/14/2006 2:56:15 AM PST by Dr. Scarpetta
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To: Coleus; nickcarraway; narses; Mr. Silverback; Canticle_of_Deborah; TenthAmendmentChampion; ...
Pro-Life PING

Please FreepMail me if you want on or off my Pro-Life Ping List.

13 posted on 11/14/2006 5:46:05 AM PST by cpforlife.org (A Catholic Respect Life Curriculum is available at KnightsForLife.org)
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To: Lunatic Fringe
embryonic stem cell research is so new

When did embryonic stem cell research begin?

14 posted on 11/14/2006 7:27:23 AM PST by syriacus (Millions in South Korea are free because 30,000 US troops DIED in 3 years under TRUMAN.)
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To: Lunatic Fringe
Of course in pointing out that this is ADULT stem cell therapy, you will also point out that embryonic stem cell research is so new that it has not yet been approved for human trials... right?

Instead of just waiting for you to provide me with a date on which embryonic stem cell research began... I've taken a quick look and found this reference...

AU Thiennu H. Vu, Gail R. Martin, Pauline Lee, David Mark,    Alice Wang, and Lewis T. Williams; TI "Developmentally Regulated Use of Alternative Promoters    Creates a Novel Platelet- Derived Growth Factor Receptor    Transcript in Mouse Teratocarcinoma and Embryonic Stem    Cells."; SO Mol. Cell. Biol. 9:4563-4567(1989).
I suspect embryonic stem cell research began before 1989, but I hate to waste time doing the research on an issue you brought up.

Please let me know what you know. Thank you.

15 posted on 11/14/2006 7:40:24 AM PST by syriacus (Millions in South Korea are free because 30,000 US troops DIED in 3 years under TRUMAN.)
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To: Lunatic Fringe

Those who are not being entirely truthful are those who are claiming embroyonic stem cells are the path to enlightenment and health for all. There has yet to my knowledge been any confirmed successful treatment using embroyonic stem cells. There have been some promising uses but they tend to be double edged such as the example below.

"Hans Keirstead and his colleagues in the Reeve-Irvine Research Center at UC Irvine have found that a human embryonic stem cell-derived treatment they developed was successful in restoring the insulation tissue for neurons in rats treated seven days after the initial injury, which led to a recovery of motor skills. But the same treatment did not work on rats that had been injured for 10 months. The findings point to the potential of using stem cell-derived therapies for treatment of spinal cord damage in humans during the very early stages of the injury. The study appears in the May 11 issue of The Journal of Neuroscience."

Also there has never been a ban on embryonic stem cell use though we hear every time the issue comes up which is the most dishonest approach to the argument. The absolute worst place to place research dollars in my opinion is with the government while many very good military and space applications have arison from government funded research most assessments would conclude that such research is highly wasteful and for every success millions of dollars go down the tubes. The reason is because of the very structure of government bureaucracy which does not reward efficiency and is likely as not to continue funding a dead end or useless bit of research as they are to fund something substantial and promising. It isn't about the reasearch, it is about the control of funding and the promise of increasing funding.

I strongly support the use of adult stem cells. I don't know why we are even considering embryonic stem cells other than as an attempt to bulwark the empty "moral" argument of the proabortion prodeath left how else do you explain such support for something that has shown so little practical promis? The problem is the facts do not matter not even to conservatives when hope is what is for sale.


16 posted on 11/14/2006 7:49:22 AM PST by Maelstorm (Soldiers need our support, our courage, and our prayers. Not our second guessing and our cowardice.)
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To: syriacus
1981 - mouse embryonic stem cells are derived from the inner cell mass
17 posted on 11/14/2006 7:55:03 AM PST by syriacus (Millions in South Korea are free because 30,000 US troops DIED in 3 years under TRUMAN.)
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To: Lunatic Fringe
1981, mouse embryonic stem cells are derived from the inner cell mass.

There've been 25 years of mammalian embryonic stem cell research.

18 posted on 11/14/2006 7:59:17 AM PST by syriacus (Millions in South Korea are free because 30,000 US troops DIED in 3 years under TRUMAN.)
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To: syriacus
Hwang Woo Suk, embryonic stem cell researcher and fraud. What a waste of money.
19 posted on 11/14/2006 8:10:18 AM PST by syriacus (Millions in South Korea are free because 30,000 US troops DIED in 3 years under TRUMAN.)
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