Posted on 10/19/2021 2:07:22 PM PDT by ConservativeMind
Identifying the dynamic events occurring during urinary tract infections (UTI) has revealed a new potential strategy to combat this condition, considered the most common type of infection. Researchers have discovered that the sequence of events taking place during UTI sustains a delicate balance between the responses directed at eliminating the bacteria and those minimizing tissue damage that may occur in the process.
The NRF2 pathway stood out as a key contributor to this balance, by regulating both the potential damage to tissues and the elimination of bacteria. Treating an animal model of UTI with the FDA-approved, anti-inflammatory drug dimethyl fumarate (DMF), a known NRF2 activator, reduced tissue damage and bacterial burden, opening the possibility that DMF could be used to manage this condition in the future.
"More than 85% of UTI are caused by uropathogenic E. coli (UPEC), bacteria that can attach to the surface of the epithelial cells lining the inside of the bladder, called urothelial cells," said first author Dr. Chetanchandra S. Joshi, a postdoctoral associate in the Mysorekar lab. "Attached UPEC can then enter the urothelial cells, where they reproduce. In the current study, we looked at how urothelial cells fight back UPEC invasion and proliferation while preserving their integrity, which is essential for proper bladder function."
Understanding the process that follows a UPEC infection revealed a potential new strategy to combat the condition. "We learned that active NRF2 was involved in both neutralizing ROS, which helped protect urothelial cells, and eliminating UPEC," Joshi said. "These findings suggested that a drug that activated NRF2 might help clear UPEC infections."
"…we showed that treatment with DMF activated NRF2, dampened the immune response, limited the level of damage the bacteria caused to urothelial cells, and promoted activation of RAB27B, which removed bacteria from the bladder," Mysorekar said.
(Excerpt) Read more at medicalxpress.com ...
My mom had vascular dementia and the last few years of her life, she had frequent UTIs. There’s some connection there, but I’m not sure what. Anyway, the cranberry pills, juices, etc only helped marginally for her. She would no sooner get over one than 2 weeks later another would pop up. So I’m hoping this research helps someone like my mom. It was awful.
Problem is a single slice is not near enough Citric Acid to break down a stone...Need something like 100X more to be effective.
It sounds terrible. I know women who take a cranberry pill everyday because they get frequent UTI’s. It seems to work for them. I’m guessing that the “cure” depends on what the cause is.
Sounds nasty, but for the stones, the lemon/olive oil strategy has worked for a number of people over the years.
The stones are not really dissolved, but are passed, and everyone jas stated it is painful.
Citric acid does break them up but you have to take a good amount as it does work.
I don’t use tetracycline for anything, anyway.
Doxycycline is so much better and far more stable.
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