Posted on 10/19/2021 2:07:22 PM PDT by ConservativeMind
Identifying the dynamic events occurring during urinary tract infections (UTI) has revealed a new potential strategy to combat this condition, considered the most common type of infection. Researchers have discovered that the sequence of events taking place during UTI sustains a delicate balance between the responses directed at eliminating the bacteria and those minimizing tissue damage that may occur in the process.
The NRF2 pathway stood out as a key contributor to this balance, by regulating both the potential damage to tissues and the elimination of bacteria. Treating an animal model of UTI with the FDA-approved, anti-inflammatory drug dimethyl fumarate (DMF), a known NRF2 activator, reduced tissue damage and bacterial burden, opening the possibility that DMF could be used to manage this condition in the future.
"More than 85% of UTI are caused by uropathogenic E. coli (UPEC), bacteria that can attach to the surface of the epithelial cells lining the inside of the bladder, called urothelial cells," said first author Dr. Chetanchandra S. Joshi, a postdoctoral associate in the Mysorekar lab. "Attached UPEC can then enter the urothelial cells, where they reproduce. In the current study, we looked at how urothelial cells fight back UPEC invasion and proliferation while preserving their integrity, which is essential for proper bladder function."
Understanding the process that follows a UPEC infection revealed a potential new strategy to combat the condition. "We learned that active NRF2 was involved in both neutralizing ROS, which helped protect urothelial cells, and eliminating UPEC," Joshi said. "These findings suggested that a drug that activated NRF2 might help clear UPEC infections."
"…we showed that treatment with DMF activated NRF2, dampened the immune response, limited the level of damage the bacteria caused to urothelial cells, and promoted activation of RAB27B, which removed bacteria from the bladder," Mysorekar said.
(Excerpt) Read more at medicalxpress.com ...
- Dark chocolate - Legumes - Vegetables - Spices - Oregano - Red wine - Green and white teas
NRF2’s Role In Infections, Metabolism, & Longevity
https://mybiohack.com/blog/nrf2-cirs-sensitivities
Best cure for this is drink lots of water.
Cranberry works. We always have the pills on hand.
Bingo!
My bladder doesn’t empty because it dropped, and I would periodically get a bladder infection. I never knew it though, because I didn’t have any symptoms with them. I’d only find out when I had to give a urine sample with my fasting blood work every six months, or when I went to the urologist once a year. I started drinking Ocean Spray cranberry juice with my morning pills, specifically their diet (5 calorie) mixed-cranberry juices, ie., cran-cherry, cranblackberry, etc., and haven’t had an infection in several years now. I’m diabetic, and the 1g sugar Ocean Spray juices don’t play havoc with my blood sugar.
I generally recommend 500mg of amoxicillin every 8 or 12 hours for 3 to 7 days... almost always clears a UTI up... if it fails then keflex 250mg every 6hrs for 3 to 7 days.
and of course drink plenty of water...
As a young lieutenant I was acting Battalion Adjutant having to report medical status, the medic showed me his book with about 25 UTI cases. I asked VD? He said yes.
Proven track record. American Labs - Silver Biotics. Can’t say enough about it!!!!
My Portuguese Podengo, Gypsy, used to get *horrible* UTIs for some reason, possibly because she squats so low and Clindamycin would knock them out in a couple days.
And by horrible, I mean *really* gruesome symptoms.
Well I have battled kidney stones all my life beginning at age 16 till I finally learned to drink water pretty much all day and once I started that as I tried all the remedies prescribed by a number of Doctors nothing really worked for long so for the last 12 years been cornering the market on bottled water and not had anymore stones..
If UTI symptoms present, I find that 2000 mg Vit C, 3 x daily, and lots of water, 3 to 4 qts a day for a couple days, generally take care of things.
I have a few boxes of Clindamycin chewables for animal use here..but they are out of date... it is a very commonly used veterinary med. My late brother in law had it stocked for the farm critters.
I keep doxycycline, amoxicillin, cephalexin and ampicillin here, they are common and cheap being off-patent... a small pharmacy box of 500 is generally less than 100.00
Kidney stones are just no fun at all :-(
Keep drinking that water :-)
You are a person after my own heart.
I also have my own little critter pharmacy.
Don’t toss out the Clindamycin as the expiration dates are generally bogus.
Army studies showed that meds in stable tablet form were nearly as potent 50 or more years later.
That’s true but there are some meds that do weaken.. I believe tetracycline expiration dates are important... just something I remember reading somewhere..
We always kept such things in a small fridge at about 50-60F
They should never be too cold or too hot.
Yes, and I add a lemon slice to mine.
Bumpity bump!
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