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Cancer Cells Can't Proliferate and Invade at the Same Time
Scientific American ^
| 1/1/16
| Viviane Callier
Posted on 01/04/2016 12:40:51 AM PST by LibWhacker
Cancer Cells Can't Proliferate and Invade at the Same Time
The new findings could inform cancer treatments, which typically target only cells that are dividing
Lumps and hairlike projections are characteristic of cancer cells, such as the cervical cancer cell shown here.
STEVE GSCHMEISSNER Science Source
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The worst cancer cells don't sit still. Instead they metastasizeâmigrate from their original sites and establish new tumors in other parts of the body. Once a cancer spreads, it is harder to eliminate. A study by developmental biologists offers a fresh clue to how cancer cells acquire the ability to invade other tissuesâa prerequisite for metastasis. It reveals that invasion requires cells to stop dividing. Therefore, the two processesâ invasion and proliferationâare mutually exclusive. The finding could inform cancer therapies, which typically target rapidly proliferating cancer cells.
David Matus of Stony Brook University and David Sherwood of Duke University turned to a transparent worm to elucidate this invading process. During the worm's normal development, a cell known as the anchor cell breaks through a structure called the basement membrane, which initially separates the uterus from the vulva. The process is similar to how human cancer cells invade basement membranes to enter the bloodstream, which carries them to distant sites. So biologists have adopted Caenorhabditis elegans as a metastasis model organism, which they can easily image and genetically manipulate.
After turning on and off hundreds of genes in C. elegans, Matus's team found a gene that regulated anchor cell invasion. When it was turned off, the anchor cell failed to invade the basement membrane. But the anchor cell also did something unexpected: it began to divide. Conversely, when the researchers inhibited cell proliferation, the anchor cell stopped dividing and began to invade again. Further experiments showed that halting cell division was both necessary and sufficient for invasion. Although anecdotal observations by pathologists have suggested this either/or situation might be the case, the new study is the first to uncover the genetic mechanism that explains why these two processes must be mutually exclusive. The results were published in October in the journal Developmental Cell.
The study also explains the long-standing but mysterious observation by cancer biologists that the invading front of many tumors does not contain dividing cells; instead the invasive cells lead the dividing cells behind them and push forward into healthy tissue as the tumor grows in size. âThis research changes how we think about cancer at some level,â Matus says. âWe think of cancer as a disease of uncontrolled cell division, and in fact, many cancer drugs are designed to target these dividing cells. But our study suggests that we need to figure out how to target these nondividing cells, too, as these are the ones that are invasive.â
Before the insight makes its way into cancer treatments, however, it will need further testing. âNow we can take that simple model and go to more complex systemsâlike breast cancer tumors,â says Andrew Ewald, a cancer cell biologist at Johns Hopkins University. Metastatic breast cancer alone accounts for about 40,000 deaths every year in the U.S., but the five-year survival rate is nearly 100 percent if caught before the cancer spreads.
TOPICS: Health/Medicine; Science
KEYWORDS: cancer; cancercells; cells; invade; proliferate
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To: LibWhacker
The worst cancer cells don't sit still. Instead they metastasizeââ¬âmigrate from their original sites and establish new tumors in other parts of the body. Once a cancer spreads, it is harder to eliminate. Your immune system should stop cancer.
But for many people it doesn't.
There is no cure for cancer yet, only exotic treatments.
I don't think there will be any real cures, until it is figured out how to get the patients immune system working against cancer.
There are some examples of actual "Miracle cures", but I believe the immune system finally gets on the case, for unknown reasons. - tom
To: Enlightened1; petercooper
22
posted on
01/04/2016 12:18:29 PM PST
by
goodnesswins
(hey..Wussie Americans....ISIS is coming. Are you ready?)
To: goodnesswins
Cyanide, which occurs naturally in B17 is lethal to cancer cells only. No documented cases of anyone dying from eating apricot kernels. Meanwhile, chemo has killed millions and millions. Cancer is big business. Follow the money.
23
posted on
01/04/2016 12:54:01 PM PST
by
petercooper
(Coexist my ass!)
To: Yaelle
Hi Yaelle! the common thinking on seaweed for a source of iodine is a no go as they believe there is too much arsenic in it.
I take Iodoral (50mg/day) which is made up of the correct ratio of iodine to iodide and it is in higher doses instead of mcg’s.
When you take iodine the offset mineral is selenium, both of which really help your thyroid and the conversion of T4 to T3. The remainder of the protocol is 600-800mg magnesium (I like the form of glycinate), 1/8 tsp of salt 3-7 days a week, dropped on your tongue to dissolve then flush with 16 oz water and about 4000 mg of vitamin C.
Are you having any particular health issues? Even if you’re not, of course, this is one of the most effective regimens you can be on. Just curious if you’re dealing with anything.
To: Yaelle
D’oh! read the other post first.
Just gave you the regimen. Iodine is HUGELY effective against cancer; in fact I contend it is ‘the’ issue when dealing with cancer (ie the deficiency of it).
We are all very deficient in iodine. As an example, the Japanese get, on average, about 15mg/day and have a very low incidence of cancer in their country.
I also believe that our tissues expand to seek iodine in the body and can lead medical “experts” to determine you have a growth of some sort when in fact it’s iodine deficiency. Cases in point: goiter, breast fibroids, uterine fibroids, enlarged prostate are all related to iodine deficiency.
To: originalbuckeye
I donât know where the author got the info that the basement membrane separates the uterus from the vulva. The article is probably trying to specify that the specific membrane in question in the worm is the one separating the uterus from the vulva.
I long ago realized that scientific topics written for lay people often leave out details whose lack makes the articles terribly uninformative and often nonsensical. This is why I no longer read scientific articles targeted at a lay audience.
26
posted on
01/04/2016 4:17:46 PM PST
by
exDemMom
(Current visual of the hole the US continues to dig itself into: http://www.usdebtclock.org/)
To: petercooper; spacejunkie2001
Vitamin B17, found in apricot kernels, also causes apoptosis. Please be aware that there is no such thing as "Vitamin B17"; this is another name for laetrile, which is nothing more than cyanide.
I do not know what the "alternative medicine" significance of apoptosis is, but in real science, it is a programmed cell death that is triggered by many conditions that disrupt a cell's normal growth. Cells decide to die rather than try to continue to grow (i.e. divide) with multiple damages. Being able to induce apoptosis is not necessarily a good thing, since many toxins (ricin, abrin, dioxin, etc.) cause apoptosis.
27
posted on
01/04/2016 4:23:32 PM PST
by
exDemMom
(Current visual of the hole the US continues to dig itself into: http://www.usdebtclock.org/)
To: spacejunkie2001
I am kind of dealing with things, yes. Macro prolactinoma and (once erosive) oral lichen planus. The former seems to affect a lot of different things hormonally.
I already take the magnesium, also glycinate. I feel I need to start with the iodine. Thanks so much, I will get some and selenium.
28
posted on
01/04/2016 4:29:45 PM PST
by
Yaelle
(Since PC is not actually "correct," it should be renamed Political Pandering.)
To: spacejunkie2001
Absolutely fascinating and makes so much sense. Thanks.
The cancer racket is obscene. My cousin has been poisoning herself for months after breast cancer surgery, probably all overkill and absolutely harming her general health maybe forever. It’s so awful. I would have refused those months of chemo and the weeks of radiation.
29
posted on
01/04/2016 4:31:55 PM PST
by
Yaelle
(Since PC is not actually "correct," it should be renamed Political Pandering.)
To: exDemMom
To: Yaelle
Read the article I posted at #30.
I refuse to participate in ANYTHING that “benefits” Komen or any of the other breast cancer events as I fully believe they are destroying women’s lives for a) telling them they saw something on a mammogram which was most likely either a calcification (sign of mag deficiency) or b) expanded tissue due to iodine deficiency.
God made it clear in Genesis that we are made from the dust; dust is dirt and dirt is minerals. We absolutely need to supplement with minerals. The right kind, right brand, right amount, all the time.
To: goodnesswins
hashi’s and all other thyroid issues are related to iodine deficiency. The key is to take 50-100mgs of iodine a day and it will eliminate the antibodies.
Look up Stephanie Buist. She had thyroid cancer and husband had hashis. She cured both with iodine. She has a site on facebook which I think is called iodine 4 health.
back to the original comment; you need iodine as much as someone without hashi. be sure to do the selenium, salt, mag and C as well.
To: spacejunkie2001
I’ll check it out...thx...btw, I am under care of someone trained by Dr. Jonathan Wright, MD,ND...and she says to avoid iodine...so may have to re-educate her ...
33
posted on
01/04/2016 5:44:25 PM PST
by
goodnesswins
(hey..Wussie Americans....ISIS is coming. Are you ready?)
To: goodnesswins
Tell her to call Dr. David Brownstein’s office in MI. He’ll give her everything she needs to know about any thyroid issue out there.
A really good site to check out is Stop The Thyroid Madness. You will be fully educated there as well.
Good luck and God bless :)
To: goodnesswins
Either this guy is dumb as the day is long or more likely completely paid off to mislead people.
Do your own research and look at all sources and read what they have to say. Just because you find one link that says what you want to hear..., then that does not make it the truth.
There is plenty of evidence if you take the time to look it up too.
Listen to all sides and drawl your own conclusions.
I do like Dr Mercola and agree with most of what he says. However, I can assure you eating Apricot seeds will not kill you. If it were true, then I would have been dead a long time ago. Furthermore, the companies that sell to the public would already be out of business
Absolute rubbish to scare people in order to make money, It's disgusting!
Vitamin C is very good choice, but make sure it's natural vs. Synthetic.
To: Enlightened1
Dr Weil I don’t trust...Dr Mercola I usually trust except when he goes off on way out there environmental issues...I’m open minded and do lots of research...which I still will do
36
posted on
01/05/2016 6:39:03 AM PST
by
goodnesswins
(hey..Wussie Americans....ISIS is coming. Are you ready?)
To: Enlightened1
Follow the money. Big C tries to destroy all alternative treatments for cancer. There is a Dr. Cimonicini (I think) in Italy who has documented cases of curing cancer with baking soda. He had his license revoked and was thrown in jail for a time.
37
posted on
01/05/2016 7:04:46 AM PST
by
petercooper
(Coexist my ass!)
To: spacejunkie2001
38
posted on
01/05/2016 7:09:12 AM PST
by
petercooper
(Coexist my ass!)
To: Smokin' Joe
Thanks, I’ll send a ping. There have been so many interesting studies lately.
To: LibWhacker; AllAmericanGirl44; Armen Hareyan; B4Ranch; Balata; Ban Draoi Marbh Draoi; ...
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