p53 and metabolism

Nature Reviews Cancer ^ | October 2009 | Karen H. Vousden & Kevin M. Ryan

[neverdem]

Nature Reviews Cancer 9, 691-700 (October 2009) | doi:10.1038/nrc2715

Abstract

Although metabolic alterations have been observed in cancer for almost a century, only recently have the mechanisms underlying these changes been identified and the importance of metabolic transformation realized. p53 has been shown to respond to metabolic changes and to influence metabolic pathways through several mechanisms. The contributions of these activities to tumour suppression are complex and potentially rather surprising: some reflect the function of basal p53 levels that do not require overt activation and others might even promote, rather than inhibit, tumour progression...

[neverdem]

If you can't access the article, register at Nature. It's free.

[grey_whiskers]

Thanks, bfl.

But now, bed (long overdue).

Cheers!