I'll need to see ID for everyone in this car. Registration and proof of insurance, too.
Posted on 08/03/2022 9:24:20 PM PDT by LibWhacker
A team of researchers located at Helmholtz Munich reports on a novel function of vitamin K, which is generally known for its importance in blood clotting. The researchers discovered that the fully reduced form of vitamin K acts as an antioxidant efficiently inhibiting ferroptotic cell death. Ferroptosis is a natural form of cell death in which cellular iron plays an important role and which is characterized by the oxidative destruction of cellular membranes. In addition, the team identified FSP1 as the warfarin-insensitive enzyme reducing vitamin K, the identity of which had been postulated but remained unknown for more than half a century.
During the last years, ferroptosis has been implicated as a driver of Alzheimer's disease and acute organ injuries among many other diseases. Thus, the present findings put forward the concept that vitamin K treatment might be a new powerful strategy to ameliorate these ferroptosis-related diseases.
Vitamin K is a potent ferroptosis suppressor
Since ferroptosis prevention is considered a highly promising approach for the therapy of many degenerative diseases, new mechanisms and compounds regulating ferroptosis are extensively being explored. To identify these new molecules, a team of researchers led by Dr. Eikan Mishima and Dr. Marcus Conrad, both from the Institute of Metabolism and Cell Death at Helmholtz Munich, along with collaborators from Tohoku University (Japan), University of Ottawa (Canada) and Technical University of Dresden (Germany), systematically studied a number of naturally occurring vitamins, as well as their derivatives. "Surprisingly, we identified that vitamin K, including phylloquinone (vitamin K1) and menaquinone-4 (vitamin K2), is able to efficiently rescue cells and tissues from undergoing ferroptosis," Dr. Eikan Mishima, first author of the study explained.
Unraveling the long sought-after vitamin K reducing enzyme FSP1
In 2019 a team of researchers around Dr. Marcus Conrad already identified an enzyme as a novel and strong inhibitor of ferroptosis: ferroptosis suppressor protein-1, short FSP1. The research team now found that the fully reduced form of vitamin K (i.e., vitamin K hydroquinone) acts as a strong lipophilic antioxidant and prevents ferroptosis by trapping oxygen radicals in lipid bilayers. In addition, they identified that FSP1 is the enzyme that efficiently reduces vitamin K to vitamin K hydroquinone, thereby driving a novel non-canonical vitamin K cycle. Since vitamin K is critically involved in blood clotting processes, the team further showed that FSP1 is responsible for the vitamin K-reduction pathway insensitive against warfarin, one of the most commonly prescribed anticoagulants.
Breakthrough in understanding vitamin K metabolism
Unraveling the identity of this enzyme solved the last riddle of vitamin K metabolism in blood clotting and elucidated the molecular mechanism of why vitamin K constitutes the antidote for overdosing of warfarin. "Our results therefore link the two worlds of ferroptosis research and vitamin K biology. They will serve as the stepping stone for the development of novel therapeutic strategies for diseases where ferroptosis has been implicated," Dr. Marcus Conrad highlighted. In addition, since ferroptosis most likely constitutes one of the oldest types of cell death, the researchers hypothesize that vitamin K might be one of the most ancient types of naturally occurring antioxidants. "Thus, new aspects of the role of vitamin K throughout the evolution of life are expected to be unveiled," Dr. Marcus Conrad explained.
The research was published in Nature.
Just take a multivitamin and cover all the bases.
I'll need to see ID for everyone in this car. Registration and proof of insurance, too.
You hade been 82 for the last two years, I would say your at least 84 or better by now.
Take a look at FLCCC.
Yup. And Zinc and Quercitin per FLCCC. and Dr. Zalensky.
Are you sure you didn’t mean 1000mg of D3?
That was mean and unnecessary.
No sir. I was 81 last year. And 80 in 2020 when Biden won by hiding in his Basement it was a smart move by Biden. If voters had seen how senile and lefty liberal he was, he would have lost.
LOL. I always enjoy reading your funny posts.
Only reason I mention my age is because I want all freezers to follow my health habits and live longer than lefty liberals. If I can do ballet dancing at 82, it proves daily aerobic 30 minute exercise is better than any vitamins, better than any nutrition supplements. I picked up daily exercise habit at age 59 to try to cure so many health issues I had and was forced to retire from a secure high paying job with government. Now I have zero health issues and age 100 in good health and with ample energy looks possible. Have a blessed day.
Here’s what I take every day, split between morning and evewning:
Rx Meds (7.22.2022):
Eplerenone 50 Mg Tablet
Lisinopril 2.5 Mg Tablet 2x/day
Prednisolone Acetate 1 % Eye Drops, suspension
Pacerone 100 Mg Tablet
Metformin 1,000mg
Nitroglycerin 0.4 Mg Sublingual Tablet (if needed)
Furosemide 40 Mg Tablet
Amlodipine Basylate 10mg
Doxycycline Hyclate 100 Mg Capsule
Lorazepam 1 Mg Tablet
Valium 10mg (if needed)
Ondansetron 4 Mg Disintegrating Tablet
Zolpidem ER 12.5 Mg Tablet, Extended Release
Finasteride 5 Mg Tablet
Cyclobenzaprine 10 Mg Tablet
Metoprolol Succinate Er 50 Mg Tablet, Extended Release 24 Hr
Pantoprazole 40 Mg Tablet 2x/day
Combivent Respimat 20 Mcg-100 Mcg/actuation Solution For Inhalation
Meloxicam 15 Mg Tablet
Tamsulosin 0.4 Mg Capsule
Tramadol 50mg
Nystatin 100,000 Unit/ml Oral Suspension
Furosemide 20 Mg Tablet
Methylprednisolone 4 Mg Tablets In A Dose Pack
Cholecalciferol (vit D3) 1,000 Unit-vitamin K2 (mk4) 100 Mcg Tablet
Gabapentin 300mg (Peripheral Neuropathy in feet)
Atorvastatin 80 Mg Tablet
Entresto 97/103mg, 2x/day
Jardiance 25mg
Carvedillol 12.5mg
OTC Meds:
Aspirin Coated 81mg
Centrum Silver Multi-Vitamin
Phillips Probiotic
Zinc 50mg
Vitamin D3 5,000units
Vitamin B-1 100mg
Prevagen
Presser Eye Vitamins
Nicoderm Cq 14 Mg/24 Hr Daily Transdermal Patch
Vitamin C 1,000mg
Magnesium 500mg
COQ10 100mg
Quercetin 500mg
Solomon’s Seal 1,000mg
Camu Supreme 2,650mg
Grape Seed Extract 300mg
Fish Oil 1,000mg
Wow! I’d steer clear of open flames
Apoptosis, Pyroptosis, and Necrosis: Mechanistic Description of Dead and Dying Eukaryotic Cells
I’m listening. Personal testimony gets my attention. Excellent! :-)
“That was mean and unnecessary.”
So are democrats.
Started taking vitamin K a few months ago after I read an article here on FR showing it was producing positive results in mice with brain function.
Get your D3 tested. Shoot for 75 ng/ml. You get there by taking 10000 D3 daily. And it costs $2 less than last year. Or take one every other day to make it 5000 D3 daily
https://www.amazon.com/Carlyle-Vitamin-Softgels-Promotes-Supplement/dp/B07GRBQY5B
If I get to 90 ng/ml that’s OK with me. But my last test came in at 75
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