Calgary researchers hope to prove Hydroxychloroquine effective in COVID-19 treatment

CTV News ^ | 04/14/2020 | Kevin Green

[Diogenesis]

given that it is already proven,
in addition to confirming so many others,
they should compare one arm of zinc addition to HCQ,
to just HCQ.

[Chicory]

How do we test potentially life-saving drugs? Basically, we are asking people to run the risk of being in the group that doesn’t get the medicine and this suffering and possibly dying?

[moonhawk]

the whole point of the HCQ is to get Zinc into the cells. What’s the point of a study without the Zinc?

[null and void]

HOCQ only, or with the synergistic Z-Pack, Zinc and Vitamins C & D₃?

[Right Wing Assault]

hope to prove

Not good for a scientist to have a bias going into a trial.

Maybe that's a "journalist" phrase.

[null and void]

The same way we proved parachutes save lives, controlled years-long peer-reviewed double blind studies. DUH!

[SeekAndFind]

RE: Basically, we are asking people to run the risk of being in the group that doesn’t get the medicine and this suffering and possibly dying?

Yes, it’s called the RANDOMIZED CLINICAL TRIAL ( AKA Double blind study ). One group gets a placebo ( but in the case of Covid-19, the standard treatment, non-HCQ is also given, and the other treatment with HCQ ).

So, patients are not really withheld any treatment at all.

[Chicory]

LOL!

[Fido969]

“hope to prove effective”?

What kind of scientific attitude is that?

[SeekAndFind]

RE: “hope to prove effective”?

What kind of scientific attitude is that?

_________________________

What should it be then? “Hope to prove ineffective?”

[Fido969]

What should it be then? “Hope to prove ineffective?

"Hope to determine whether or not"

[SeekAndFind]

RE: “Hope to determine whether or not”

Hope is a very HUMAN thing. So Hope to prove effective is natural for someone who wants something to work.

I can Hope that my therapy works BUT I have to be objective even if the result of my research dashes my hope. If it confirms it, so much the better, if it does not, I still have to (sadly) report it.

[Steve Van Doorn]

hydroxychloroquine works in two ways
1. HCQ is a zinc ionosphere (which many doctors are NOT utilizing. As they're not giving the patient additional zinc for this reaction to work.
2. (My summary)HCQ is an Alkali which bonds to the hemoglobin(Hemoglobin carries oxygen.) Where the mutated cell by the SARS-CoV-2 (called Viroprotein Orf3a) is acidic which oxidizes the iron in the heme(part of the hemoglobin.) Without the Iron the Oxygen can't bond to the hemoglobin. The HCQ neutralizes the Viroprotein Orf3a.
HCQ neutralizing the viroprotein you can find here

COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism
https://ravikollimd.com/resources/COVID/COVID-19__Attacks_the_1-Beta_Chain_of_Hemoglobin_and_Captures_the_Porphyrin_to_Inhibit_Human_Heme_Metabolism_v5.pdf

Macrophages(white blood cell) require tons of asorbic acid to generate Nitric oxide which they use to create their oxidative burst. Asorbic acid is the ammunition for your white blood cells it last literally ten minutes in your blood and it's gone. If the person is very sick an asorbic Acid IV of +3 grams a day is KEY for this to work.

As a preventative
I'm eating capers which is very high on Quercetin and taking zinc sulfate lozenges (acetate)
The vitamins LOTS of C. vitamin D is to block the virus from bonding. Vitamin B1 brakes down carbohydrates which the virus likely feeds.

[Norseman]

>>Not good for a scientist to have a bias going into a trial.<<

That’s the reason good trials are “double”-blind. Not only doesn’t the patient know whether he’s getting the drug or the placebo, but the person administering the drug doesn’t know either.

That way there’s no “wink, wink” from the administrator to the patient when the patient inevitably starts prying to find out which one he’s getting.

[Right Wing Assault]

Yes, Hope is human. Yes, we have to be objective even if the result of our research dashes our hope.

But there are cases in which the researchers succumb to other human traits that are not as noble as hope. Cheating to be the first. To get ahead to be noticed by your company or university. Or to get famous. Or not cheating but almost sub-consciously giving to more attention to outcomes the way you would like it to be and ignore those that don't. These not-so-good traits more found in individuals, but can can also happen in a group. Often there is pressure to get results, one way or the other. Well, why not go for the "best" result.

Here are a few related articles about this problem. There are hundreds of them. A good number of them point out that biomedical research is the most likely to have problems.

https://www.livescience.com/64353-top-retracted-papers-2018.html

https://en.wikipedia.org/wiki/List_of_scientific_misconduct_incidents

https://www.scientificamerican.com/article/an-epidemic-of-false-claims/

https://phys.org/news/2018-07-beware-scientific-studiesmost-wrong.html

I was a science teacher for 40+ years and I often pointed out bad or intentionally bad research.

A favorite was a fellow who claimed he could easily produce a chemical needed in cancer research. The problem was that the chemical he provided to several researcher groups was close, but still a fake, and he knew it. They trusted the chemicals. But one thorough researcher had it analyzed. Yes, fake. Money was wasted on the earlier research and wasted time of the researchers.

Although this next one was humorous, but...

https://faseb.onlinelibrary.wiley.com/doi/pdf/10.1096/fj.06-0401ufm

[Right Wing Assault]

Yes, a carefully done double-blind trial would work well with this kind of research. Setting it up is not the fastest process. In a possibly death or life situation, which is imminent for some patients, the double-blind takes too long.

There must be some fast attempts to save lives, as some are doing, while the double-blind is moving along. The use of highly-safe medications should not be forbidden. There is not the rigor of the double-blind but if done by enough teams, it will give some important information quickly and may save some lives that might have been lost.

Also, there are arguments among researchers of the use of the "lying" process of the double-blind. They know half of the hopeful Covid patients could die to save other lives later. Imagine your husband (or wife), and you, are thinking, "This could be a life saver!" only to watch them die because they drew the short straw. I would have a problem when my spouse could have had something a week ago, like HCQ, Zinc, and Z-pack.

[Atticus]

Best of luck with your protocol. I just started supplementing with 600 mg of quercetin (300 mg twice daily) and 50 mg of zinc citrate (25 mg twice daily). That is in addition to a potent daily multiple and 5000 IU of Vitamin D3. If that fails to ward off the coronavirus I have an arthritic family member who has promised to spare some hydroxychloroquine. How much Vitamin C is “lots”?

[Steve Van Doorn]

I take about a 1000 mg a day of Vitamin C. It's better if you take two 500 mg per day. If you're feeling you coming down with something +3 grams broken up throughout the day.
Doctors that are using vitamin C for those that are sick take it to the point where they don't get diarrhea 5 to 6 grams I think

[Atticus]

Thanks. Sounds right.