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Allergy Drugs Fight Obesity and Diabetes in Mice
Nature Medicine via Ivanhoe Newswire ^ | July 29, 2009 | NA

Posted on 07/31/2009 12:36:25 PM PDT by neverdem

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Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
1 posted on 07/31/2009 12:36:27 PM PDT by neverdem
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To: neverdem
"Crack open the latest medical textbook to the chapter on type 2 diabetes and you'll be hard pressed to find the term 'immunology' anywhere."

That's astonishing, considering it's an autoimmune disease.
2 posted on 07/31/2009 12:39:45 PM PDT by RightOnTheLeftCoast (I love my country, but I fear it, for it does not love me.)
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To: austinmark; FreedomCalls; IslandJeff; JRochelle; MarMema; Txsleuth; Newtoidaho; texas booster; ...
FReepmail me if you want on or off the diabetes ping list.
3 posted on 07/31/2009 12:40:11 PM PDT by neverdem (Xin loi minh oi)
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To: neverdem

Healthy mice. OK.


4 posted on 07/31/2009 12:40:49 PM PDT by verity
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To: neverdem

Perhaps I should inject my Zaditor eye drops.


5 posted on 07/31/2009 12:42:26 PM PDT by TheThirdRuffian (Defend America from the Communist.)
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To: neverdem
...feed em Little Debbie pastries and recheck em...if ya can catch em
6 posted on 07/31/2009 12:44:06 PM PDT by Doogle (USAF.68-73..8th TFW Ubon Thailand..never store a threat you should have eliminated))
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To: RightOnTheLeftCoast

Whoops, I see they’re talking Type 2. Strike that comment.


7 posted on 07/31/2009 12:44:11 PM PDT by RightOnTheLeftCoast (I love my country, but I fear it, for it does not love me.)
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To: TheThirdRuffian

>>two common over-the-counter allergy medications to reduce both obesity and type 2 diabetes in mice<<

Are these over the counter?
I thought they were by script only.


8 posted on 07/31/2009 12:46:33 PM PDT by netmilsmom (Psalm 109:8 - Let his days be few; and let another take his office)
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To: RightOnTheLeftCoast
That's astonishing, considering it's an autoimmune disease.

Show me. Type 2 diabetes is characterized by insulin resistance. Type 1 diabetes is the type associated with autoimmunity and insulin dependence since the islet cells were attacked and can no longer make insulin.

9 posted on 07/31/2009 12:46:33 PM PDT by neverdem (Xin loi minh oi)
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To: neverdem

Ping for later


10 posted on 07/31/2009 12:48:37 PM PDT by wintertime (People are not stupid! Good ideas win!)
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To: neverdem

My husband (type 2 diabetic) has been having terrible allergy/drainage problems lately. I want him to read this, thanks for the ping.


11 posted on 07/31/2009 12:51:21 PM PDT by Ditter
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To: netmilsmom

Zaditor is a OTC eye drop. Don’t know about the other one.


12 posted on 07/31/2009 12:55:35 PM PDT by TheThirdRuffian (Defend America from the Communist.)
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To: neverdem
Researchers used two common over-the-counter allergy medications to reduce both obesity and type 2 diabetes in mice. The medications, called Zaditor and cromolyn, stabilize a population of inflammatory immune cells called mast cells....

....Mast cells are immune cells that facilitate healing in wounded tissue by increasing blood flow to the site. In certain conditions, however, mast cells build up to levels far beyond what the body needs. When this happens, these cells become unstable and eventually, like punctured trash bags, leak molecular "garbage" into the tissue. This results in chronic inflammation that can cause asthma and certain allergies.

As Shi and postdoctoral research fellow Jian Liu discovered, mast cells were far more abundant in fat tissue of obese and diabetic humans and mice than they were in fat tissue from individuals of normal weight. This led to the obvious question, by regulating mast cells, could we then control the obesity and diabetic symptoms?...

....The mice were divided into four groups. The first was the control group. The second group was simply switched to a healthy diet. The third was given cromolyn or Zaditor. And the fourth group was given the drug and switched to a healthy diet.

While symptoms of the second “healthy diet” group improved moderately, the third “allergy medicine” group demonstrated dramatic improvements in both body weight and diabetes. The fourth group exhibited nearly 100 percent recovery in all areas.

Ping for later

13 posted on 07/31/2009 12:57:29 PM PDT by Alex Murphy ("I always longed for repose and quiet" - John Calvin)
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To: neverdem
It has been common knowledge for years that older type allergy medicines like Benadryl, Contac, and Tavis D, depress appetite. So much so that years ago Contac marketed an OTC appetite suppresant that was essentially Contac marketed as an appetite suppresant.

The newer Claritin type allergy drugs do not suppress appetite so much.

14 posted on 07/31/2009 1:12:27 PM PDT by sportutegrl (If liberals could do math, they would be conservatives.)
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To: neverdem

I suppose if you could trigger an allergy to most foods that would tend to fight obesity....


15 posted on 07/31/2009 1:23:04 PM PDT by Buckeye McFrog
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To: Ditter

My mother, who died of complications of Type 2, was also extremely allergic to various pollens, dust mites, smoke, (air pollutants). She suffered terribly with sinus drainage, as did her parents (and as do I). We just went with the old adage that blue eyes and allergies go hand in hand.


16 posted on 07/31/2009 1:34:04 PM PDT by Constitutions Grandchild
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To: TheThirdRuffian

WOW, thanks!

I guess I’ll be drinking it. XD


17 posted on 07/31/2009 2:01:34 PM PDT by netmilsmom (Psalm 109:8 - Let his days be few; and let another take his office)
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To: sportutegrl

And of course, the same product that is banned in Diet Pills, Ephedra, is in asthmas meds. OTC.


18 posted on 07/31/2009 2:03:30 PM PDT by netmilsmom (Psalm 109:8 - Let his days be few; and let another take his office)
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To: Constitutions Grandchild

I suffered greatly from allergies while a child. Years on shots to get to the point I could function. Multiple bouts of pneumonia resulting from chronic bronchitis.

Now I’m insulin resistant but managing my blood sugars. I’m very tempted to run out and get these OTCs just to try them for a month to see if I lose weight.


19 posted on 07/31/2009 2:04:38 PM PDT by taxcontrol
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To: TheThirdRuffian

GENERIC NAME: CROMOLYN - ORAL CAPSULES (CROW-mow-lin)
BRAND NAME(S): Gastrocrom
Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage | Medical Alert

USES: This medication is used to treat diarrhea, flushing, headache, nausea, itching or skin rash associated with mastocytosis, prevention of food allergy and certain intestinal diseases.

HOW TO USE: The medication is usually taken 1 half hour before meals and at bedtime as directed. Do not swallow the capsules. The contents of the capsules are used to make a solution. To make the solution, open the capsule and pour powder into a glass half-filled with hot water. Stir to dissolve the powder. While stirring, add cold water to fill the glass. Drink all of the solution. Do not add milk, juice or other liquids to the powder and water solution. For best results, use this medication routinely as directed.

SIDE EFFECTS: Nausea, gas, muscle aches, stomach pain or headache may occur. If any of these symptoms persist or worsen, inform your doctor. Notify your doctor promptly if you experience: mood changes, burning of the mouth or throat. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, especially of: kidney disease, liver disease, allergies. Usage in children under 2 years old is generally not recommended but there may be exceptions. Consult the child’s doctor. Tell your doctor if you are pregnant before taking this medication. It is unknown if this drug is excreted into human breast milk. Consult your doctor before breast-feeding.

http://www.medicinenet.com/cromolyn-oral_capsules/article.htm


20 posted on 07/31/2009 2:12:00 PM PDT by stlnative
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