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The Histone Code (genetic code not the only code?)
USC/Norris Comprehensive Cancer Center ^ | 2007 | Judd C. Rice, Ph.D.

Posted on 01/08/2008 7:28:22 PM PST by GodGunsGuts

click here to read article


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To: Coyoteman

[[Macroevolution is clearly defined as species-level change. Check it out! ]]

Nope sorry- it isn’t- you of course need it to be- but simple genetic change falls far short of the criteria for true MACROEvolution. Change from a species KIND to antoehr KIND is absolutely absent in the fossil record- much to the chagrin of those hwo claim any change is MACROEvolution. KINDS remain KINDS as testified by the fossil records

[[To write for them you must agree to their Statement of Faith.]]

Faithful design denialist to hte end- please tell us Coyoteman how your statement refutes ANY of the information provided on the site? It doesn’t- it’s nothign but a petty regurgitation of a NON issue. Regurgitatiing NON issues does nothign to advance your cause Coyoteman- it only shows an unwillingness (perhaps innability) to address the FACTS stated on the site

Get back to me when you can provide some actual scientific evidence linking dissimiliar species instead of just irrelevent personal opinions about a site (I don’t expect I’ll be hearing back from you any time soon then)


201 posted on 01/10/2008 2:17:33 PM PST by CottShop
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To: GodGunsGuts

Again, I’m going to have to ask you whether you are asking for a 500 million year videotape. You are pseudo-quoting Stephen Gould on the sudden appearance of new species.

Gould’s evaluation of people who misuse his writings is that they are either dishonest or stupid.


202 posted on 01/10/2008 2:21:24 PM PST by js1138
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To: js1138
Obviously sudden for me doen’t mean the same as sudden for you. But it doesn’t change the fact that there are no fossil examples of simpler organism becoming more complex organisms. All we see since the Cambrian Explosion is either extinction or devolutionary specialization.
203 posted on 01/10/2008 2:31:07 PM PST by GodGunsGuts
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To: CottShop

Very well said. Although I have noticed that at least some Darwinists are starting to acknowledge the idea of devolution (ie gene loss leading to change over time). Of course, they will never abandon the fairy tale of simple to complex evolution, but now they are starting to acknowledge “evolution” works in both directions.


204 posted on 01/10/2008 2:37:00 PM PST by GodGunsGuts
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To: GodGunsGuts; allmendream
You state;

Still, even though the histones find their origins in the wider genome...they become coding agents, conveying information from one portion of the genome, to another. Hence the code-within-code type of thinking that arrangement gives rise to. That's all I was trying to say...

I pinged you to this discussion, since he mentioned you in his last post to me. So now, I address this to him also.

205 posted on 01/10/2008 2:45:49 PM PST by BlueDragon (never set out to sea on a boat that has shiny pump handles...)
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To: GodGunsGuts

Fourtran? Ok, ok, it's Fortran, but I just couldn't resist!

206 posted on 01/10/2008 3:11:55 PM PST by BlueDragon (never set out to sea on a boat that has shiny pump handles...)
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To: BlueDragon; allmendream; CottShop; js1138; Coyoteman; metmom; Alamo-Girl; DaveLoneRanger; ...
==He was saying this, and I wasn't disputing it...am I missing something?

Hi Blue Dragon, I hope you don't think I was being combative with you, I was just trying to point out why I think the science is against Allmendream's notions about the "universal code." Those scientists who are postulating a "histone code" are saying that the evidence seems to suggest a seperate code that works with what Allmendream calls the universal code (the universal code being the genetic code). What these scientists are saying is that the histone code works with the genetic code, but it is not the same as the genetic code, in much the same way as Windows works with binary code, and yet is separate and distinct from the same.

Many scientists are even taking it a step further and postulating that the histone code is but a part of a much larger code (or codes) which they call the "epigentic code." They view this code as being "above" the genetic code because it plays a crucial role in cell differentiation, allowing for cells to take on very different physical characterists without altering what Allmendream calls the universal/genetic code in the slightest. According to these scientists, this evidence points to an epigenetic code, or a code that operates above the genetic code, that allows cells with the exact same genetic code to morph into all sorts tissues, organs, and even our overall anatomy. Allmendream would have us believe that this all reduces down to the genetic code. I think the evidence for such a notion is becoming rapidly outdated by the field of epigenetics. Indeed, the genetic code, which, if I understand allmendream's position correctly, is what he calls the universal code, may in reality be the simplest and most basic code of all. In fact, it is starting to look like the genetic code simply makes proteins in a way that is analogous to humans making bricks, whereas the epigenetic code fashions those proteins into all those cells, tissues and organs that must come together to form living organisms. Do you see how radically different epigenetics is from Allmendream's mechanistic/reductionist ideas about the genetic code being the universal code of life? Indeed, as one epigeneticist once put it, "The genetic code is the piano, the epigenetic code the tune."

PS I hope you don't mind, I am pinging yet more people to the discussion because I find this topic fascinating--GGG

207 posted on 01/10/2008 4:40:12 PM PST by GodGunsGuts
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To: BlueDragon

LOL


208 posted on 01/10/2008 4:40:59 PM PST by GodGunsGuts
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To: GodGunsGuts

My fiancee unit is coming home soon - shes in her last semester of her biochem degree (from a private Christian school even though we’re not Christians), is graduating summa cum laude in a fe months, and has verbal offers from 2 ivy league schools for her PHd. Her specific area of interest is molecular genetics, so if she isn’t loaded down with calculus homework, I’ll check in with her and see what she thinks. I’m sure she’s been following this.


209 posted on 01/10/2008 4:57:14 PM PST by GovernmentIsTheProblem (The GOP is "Whig"ing out.)
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To: BlueDragon
Ok, ok, it's Fortran, but I just couldn't resist!

You're dating yourself ;o)

210 posted on 01/10/2008 5:19:58 PM PST by editor-surveyor (Turning the general election into a second Democrat primary is not a winning strategy.)
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To: GodGunsGuts

Nope, I didn't think that at all, though for a moment it seemed as if you might have been steering me towards things I couldn't honestly agree with.

However, the balance of what you say in this last post gets us back on the right track.

211 posted on 01/10/2008 6:44:53 PM PST by BlueDragon (never set out to sea on a boat that has shiny pump handles...)
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To: GodGunsGuts
“If Allmendream is saying that somehow the DNA/Universal Code directs the myriad of functions of millions and millions of histones all by its lonesome, then the burden is on Allmendream to show how the DNA/Universal Code accomplishes this incredible feat.” GodsGunsGuts

OK. What part of this is not done by the Universal genetic code?

There are genes for histones. These are transcribed by RNA polymerase and translated into histone proteins at the ribosome according the the Universal Genetic Code; then the histone can go bind DNA and do its job.

There are genes for DNA methylase. These are transcribed into mRNA then translated into proteins (according to the Universal Genetic Code)these proteins can then bind to DNA and methylate it; increasing the affinity of the DNA for binding histones.

Histones can be Acetylated making them more or less able to bind DNA. These Histone Acetyl Transferases (HAT’s) and Histone De-Acetyl Transferases (HDAC’s) are proteins coded for by the genetic code that then interact with histones and modulate its ability to interact with DNA.

RNA polymerase can be phosphorylated by proteins coded for by the universal genetic code, this in turn effects which promoter regions of which genes it will preferentially interact with.

ARE YOU BEGINNING TO GET THE PICTURE GGG? IT IS ALL DONE BY THE UNIVERSAL GENETIC CODE. THE UNIVERSAL GENETIC CODE CAN BE TRANSLATED, EVERYTHING ELSE IS A CONTROL MECHANISM. IF ANYONE OF THESE THINGS IS AN ACTUAL CODE PLEASE TRANSLATE IT FOR ME. YOU CANNOT! WHAT INFORMATION DOES THIS “CODE” CONVEY OTHER THAN ON/OFF OR THIS/NOT THAT?

212 posted on 01/15/2008 4:04:49 PM PST by allmendream ("A Lyger is pretty much my favorite animal."NapoleonD (Hunter 08))
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