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Use of salicylate in treatment of SARS - possible contraindication ( Aspirin makes SARS worse)
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| April 27, 2003
| David E Pulleyblank, Professor of Biochemistry
Posted on 04/28/2003 5:35:00 AM PDT by TaxRelief
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Translation: Because it has been proven that aspirin causes excessed reproduction in some viruses, aspirin use may be a contributing factor in the most severe cases of SARS.
If it turns out that the worse cases did use aspirin in the early stages, then research should be directed towards how "activation of p38 MAP-kinase " affects the reproduction of the SARS virus, which in turn will lead to possible treatment drugs.
He is not suggesting that aspirin is a factor, but suggests research concerning uses of aspirin should commence immediately.
1
posted on
04/28/2003 5:35:00 AM PDT
by
TaxRelief
To: TaxRelief
This sounds similar to the etiology of Reyes syndrome. Particularly, ASA should be avoided when viral infections such as chicken pox are present.
Prairie
2
posted on
04/28/2003 5:38:13 AM PDT
by
prairiebreeze
("We will not deny, ignore or pass our problems on to other Presidents." --GWBush)
To: prairiebreeze
And some SARS patients did also have paramyovirus in their systems...
3
posted on
04/28/2003 5:40:17 AM PDT
by
TaxRelief
To: TaxRelief
The medical establishment has never liked aspirin; and has been looking for ways to discourage its use for years. It doesn't require a perscription and generates no cash flow for the makers of proprietary drugs.
Thus when the possibility is alleged to exist that aspirin is somehow a negative in connection with spreading of a virus, we tend to be very very skeptical.
Fine to study and assess the possibility at somebody elses expense. But until demonstrated otherwise, this is just another argument by the medical profession that people shouldn't use aspirin.
4
posted on
04/28/2003 6:31:09 AM PDT
by
David
To: David
Actually, drug companies don't like aspirin. MD's often recommend aspirin in low daily doses for a variety of ailments.
5
posted on
04/28/2003 6:36:11 AM PDT
by
TaxRelief
To: TaxRelief
AIDS epidemic in all countries where SARS is most dangerous.
Why the media is allowed to get away from scrubbing AIDS from the story is beyond me.
Remember, this will spread through Russia and Western Europe because AIDS is epidemic there, and yet nobody will mention the AIDS + SARS = DEATH equation.
It's ammoral.
To: David
Doctors don't like aspirin? Our Dr has advised my husband & myself to take one every day.
7
posted on
04/28/2003 6:50:48 AM PDT
by
Ditter
To: David
re: Fine to study and assess the possibility at somebody elses expense. But until demonstrated otherwise, this is just another argument by the medical profession that people shouldn't use aspirin.)))
An unaccountably silly remark. Tell that to the thousands who are recommended to take a baby aspirin every day by their doctors. Also, it's a standard now for treatment in the presentation of heart attacks.
Aspirin is a powerful med.
Docs do not have a proprietary interest in the drugs they prescribe. AAMOF, they'd like to use the cheaper drugs in some cases, but are frightened away by the prospect of litigation. Case in point, there was a cheaper treatment for heart attacks available a few years back, but the drug company with the more expensive med managed to create a better (slightly, slightly better) record on paper. The hospitals were forced to use the more expensive drug for fear that they'd end up in court--a matter of documentary evidence. As a result, treatment for heart failure suddenly cost $2700 more than it had to. Multiply that by hundreds of thousands, and it's just one example.
It's a lawyer thing, not a doctor thing.
8
posted on
04/28/2003 6:55:56 AM PDT
by
Mamzelle
To: David
The MD's I know really like aspirin. It's cheap and most of its side effects are known.
The Big Drug Companies like Bayer do like to advertise aspirin a lot on TV (So does St. Josephs.)
9
posted on
04/28/2003 7:11:17 AM PDT
by
Doctor Stochastic
(Vegetabilisch = chaotisch is der Charakter der Modernen. - Friedrich Schlegel)
To: Domestic Church
This seems to support your initial hunch about aspirin and the superspreaders.
To: CathyRyan; Mother Abigail; Dog Gone; Petronski; per loin; riri; flutters; Judith Anne; ...
I thought aspirin impeded the reproduction of viruses. Does this article mean this is not the case for at least some viruses?
To: bonesmccoy
*Ping* for your thoughts.
12
posted on
04/28/2003 8:16:23 AM PDT
by
TaxRelief
(Sorry to interrupt the orbiter stuff.)
To: TaxRelief
Aspirin can affect blood clotting, and SARS patients have a problem with bleeding in the lungs. I wonder if aspirin should be contra-indicated, regardless of its affect on the virus?
13
posted on
04/28/2003 8:20:14 AM PDT
by
EternalHope
(Boycott everything French forever.)
To: EternalHope
SARS patients have a problem with bleeding in the lungs.Another reason to research whether or not anyone has taken aspirin in the early stages of SARS.
Reyes syndrome used to kill 6000+ kids a year. Then they discovered that aspirin was the culprit behind Reyes. Now it only kills a handful of kids a year.
The problem may be an obsession with suppressing fever, rather than allowing a carefully monitored fever to do the job God intended it to do.
To: TaxRelief
Good points. They also serve to illustrate just how little we really know about SARS.
15
posted on
04/28/2003 8:30:37 AM PDT
by
EternalHope
(Boycott everything French forever.)
To: EternalHope
Aspirin can affect blood clottingIt's a good blood thinner, for preventing clots and strokes.
Viruses stop reproducing at a 101 temp which gives the body's natural defense a chance to kill them off. Taking any drug to drop the temp caused by a fever, which in turn allows the virus to reproduce , isn't the best idea. Letting the fever run it's course , even if you feel rotten , is the best thing to do. A temp over 104 is a different story.
16
posted on
04/28/2003 8:35:54 AM PDT
by
Snowyman
To: Snowyman
Thanks for the info.
17
posted on
04/28/2003 8:38:28 AM PDT
by
EternalHope
(Boycott everything French forever.)
To: EternalHope
One thing about taking aspirin for a blood thinner, save some lurker decide the more the better. Too much can cause internal bleeding or nose bleeds. It works like Warfarin , the stuff used to kill rats. The four legged kind.
We're talking a baby aspirin , every other day or less. Ask a doctor.
18
posted on
04/28/2003 8:49:18 AM PDT
by
Snowyman
To: Ditter
"Doctors don't like aspirin? Our Dr has advised my husband & myself to take one every day." Ditto...and I do.
19
posted on
04/28/2003 8:49:24 AM PDT
by
blam
To: TaxRelief
It seems that "modern" medicine is fixated on suppressing what the body is trying to accomplish. Allopathic quackery inevitably seeks to quash the symptoms whilst ignoring the cause.
Example? Water retention. There's a drug women can buy to "combat" water retention during their menstrual cycles. This highly profitable drug (for the makers) "gets rid of the bloating caused by water retention."
Question? Do these medical quacks ever pause and ask "why"? Why is the body retaining water? Could it be, and this is just a wild guess, that the body is "starved" for water? Hmmm, do ya think so?
Maybe, "water retention" is a "sign" that the person is not drinking enough water. So the medicos say; "Gee, you're retaining water, here's a drug to suppress that awful symptom. Cha-ching." What they don't say is; "You need to increase your daily water consumption."
Maybe drug companies are willing to invest $200 million dollars developing a new drug because "they care about you". Caring and sharing.
20
posted on
04/28/2003 9:33:52 AM PDT
by
handk
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