Agitprop in action? [Was: Best treatment of SARS available- Photo-oxidation]

Raymond Kwong SARS update | 4/21/03 | Watchman123

[CholeraJoe]

Quack Quack.

Thanks for the ping.

[Watchman123]

i can't believe my eyes! How can anyone trust the slant of this site! What pseudo-science which conveniently left out the good & distort the real picture. i was advised not to waste any more time answering people who already has their minds made up. i wish to help educate those who is hungry for the truth, for the truth will set you free. Nowaday, Dr. Morales 7 others are already using the advanced Quinoxide to get it into the cell, releasing singular Oxygen molecule to kill pathogens...Some of these critics live in dinosaur age, picking on hydrogen peroxide. I was just told that the latest that all major cancer research centers, including the Cancer Institute , NIH, and on and on they are actively looking into how to generate free radical oxygen inside of tumors because singlet oxygen kills tumor cells! Facts are facts. And cancer is widely condisered an anerobic event. Dr. Warberg won the Nobel proze 7 no critic can take that away from him. They may try to distort or misinterpret what he discovered.

[general_re]

Garbage. One of my undergrad chem professors was actually doing real live peer-reviewed work on light-sensitive dyes and phototherapy as a treatment for cancer - this claim that mainstream medicine is ignoring photodynamic therapy is out-and-out bullshit. But the way to do it is the way he is still doing it - careful investigation which follows accepted protocols, along with peer-review of experimental results. Notice how e-mail chain letters soliciting desperate - and therefore gullible - patients is omitted from that process.

But don't take my word for it - two abstracts of recent publications:

In vitro photodynamic properties of chalcogenopyrylium analogues of the thiopyrylium antitumor agent AA1.

Journal of Medicinal Chemistry. 45(23):5123-35, 2002 Nov 7.

Several series of chalcogenopyrylium dyes were prepared with one or two 4-anilino substituents at the 2- and 6-positions and with phenyl, 4-N,N-dimethylanilino, or 4-(N-morphilino)phenyl substituents at 2- and/or 4-positions. The dye series are all related in structure to AA1, a thiopyrylium dye that targets mitochondria. The chalcogenopyrylium nuclei included sulfur, selenium, and tellurium at the 1-position. Key intermediates in the dye synthesis were the corresponding Delta-4H-chalcogenopyran-4-ones. All of the dyes of this study were evaluated for dark and phototoxicity toward Colo-26 cells in vitro. There was no correlation of dark toxicity with either the reduction potential of the chalcogenopyrylium dye or the n-octanol/water partition coefficient, log P. Several of the dyes of this study (thiopyrylium dyes 1-S and 13-S, selenopyrylium dyes 1-Se, 2-Se, 3-Se, 4-Se, 13-Se, 14-Se, and 27-Se, and telluropyrylium dye 13-Te) showed added phototoxicity upon irradiation. Dyes with the highest therapeutic ratio as measured by dark toxicity/phototoxicity (15 J cm(-2) of 360-800-nm light) had values of log P of 1.0-1.2. Studies of cytochrome c oxidase activity in whole R3230AC cells suggested that dyes 1-S and 3-Se, with values of log P of 2.2 and 1.7, respectively, were localized in the mitochondria. Cytocrome c oxidase activity in whole cells was inhibited by 1-S and 3-Se in the dark. Chalcogenopyrylium dyes 2-Se, 4-Se, 13-Te, and 14-Se inhibited whole-cell cytochrome c oxidase activity only following irradiation, which suggests that these dyes relocalized to mitochondria following irradiation.
-----------------------
Water-soluble, core-modified porphyrins as novel, longer-wavelength-absorbing sensitizers for photodynamic therapy. II. Effects of core heteroatoms and meso-substituents on biological activity.

Journal of Medicinal Chemistry. 45(2):449-61, 2002 Jan 17.

Water-soluble, core-modified porphyrins were prepared and evaluated as sensitizers for photodynamic therapy (PDT). The addition of an aromatic aldehyde to 2,5-dilithiothiophene or -selenophene gave diol 3 as a nearly equimolar mixture of meso and d,l diastereomers, which gave a single diastereomer following careful recrystallization. The condensation of pyrrole with a diol 3 using catalytic BF(3)-etherate gave bispyrrolochalcogenophenes (4). Condensation of a diol 3 with 4 in the presence BF(3)-etherate gave 21,23-dichalcogenaporphyrins (5). 21-Thiaporphyrins (6) were prepared by condensation of a diol 3 with excess pyrrole and benzaldehyde in the presence of tetrachlorobenzoquinone and catalytic BF(3)-etherate. Sulfonation of 5 and 6 with concentrated sulfuric acid at 100 degrees C gave sulfonated derivatives 7-15. Bis-4-methoxy-21,23-dithiaporphyrins 5h and 5l were demethylated with BBr(3), and the resulting phenols were alkylated with ethyl bromoacetate. Saponification gave 21,23-dithiaporphyrin dicarboxylate salts 16 and 17. The 21,23-core-modified porphyrins gave band I absorption maxima (lambda(max) of 689-717 nm) at longer wavelengths than band I for the corresponding 21-core-modified porphyrins, but both classes had band I maxima at longer wavelengths than either TPPS(4) or Photofrin (lambda(max) of 630 nm for both). The core heteroatoms had little effect on either absorption maxima or quantum yields of singlet oxygen generation in 7-17. The meso substituents had a greater impact on absorption maxima. Compounds 7-17 were evaluated for phototoxicity against Colo-26 cells in culture using 4 J cm(-2) of 570-800 nm light. Compounds 8-12, 14, 16, and 17 gave a 50% cell kill in vitro at a lower concentration than Photofrin [5.7 mg (9 micromol)/kg]. Compounds 14, 16, and 17 gave a 50% cell kill with 4 J cm(-2) of light and submicromolar concentrations of sensitizer. Sensitizers 8 and 11 showed no toxicity or side effects in BALB/c mice observed for 90 days following a single intravenous injection of 10 mg/kg of sensitizer. Distribution studies show that sensitizer 8 accumulates in the tumors of BALB/c mice. PDT with 8 at 0.125 mg (0.13 micromol)/kg or 11 at 2.5 mg (2.5 micromol)/kg and 135 J cm(-2) of 694 nm light was comparable to PDT with Photofrin at 2.5 mg (4 micromol)/kg and 135 J cm(-2) of 630 nm light against Colo-26 tumors in BALB/c mice.

[I got the rope]

The core heteroatoms had little effect on either absorption maxima or quantum yields of singlet oxygen generation in 7-17. The meso substituents had a greater impact on absorption maxima. Compounds 7-17 were evaluated for phototoxicity against Colo-26 cells in culture using 4 J cm(-2) of 570-800 nm light. Compounds 8-12, 14, 16, and 17 gave a 50% cell kill in vitro at a lower concentration than Photofrin [5.7 mg (9 micromol)/kg]. Compounds 14, 16, and 17 gave a 50% cell kill with 4 J cm(-2) of light and submicromolar concentrations of sensitizer.

This is interesting.....

[I got the rope]

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=photofrin&dispmax=20&relentrezdate=No+Limit

[I got the rope]

What's your agenda? Are you going to selectively tell the truth like some con-man so that we will buy your BS. Your nonsense is hijacking true research.

[green team 1999]

have talked to a researcher in America whose identity I have to keep confidential for now,

never knew of this guy,he never been on the art bell show,george have to interview this guy on coast to coast and then we might consider if he is right.

[Aracelis]

Sorry, you still don't get it. Who dominates on the editorial boards of these peer refeered journals? narrowninded, arrogant establishment type who would not allow anything unorthodox or medically incorrect, no matter how credible, to get published.

Let's all just wave our magic wands instead of proceeding with research. It'll be cheaper and from of looks of things, a whole lotta people would be much happier if we abandoned science altogether. "Beads and rattles", yeah...that's the ticket!

[general_re]

I actually just picked those two since my former professor happened to coauthor them. But as you can see, 941 articles mentioning Photofrin over the last twenty years pretty clearly indicates that this is an area being actively ignored by mainstream medicine ;)

[Axenolith]

Yea, but their unit probably juices and cleans stained floors too...

[general_re]

Well, you know - I'm convinced. In fact, I'm off to the Philippines for my appointment with a psychic surgeon in a few days. And if that doesn't work, I know a world-class homeopath who's agreed to see me ;)

[handk]

Warburg papers received from Saul Pressman www.plasmafire.com

The Prime Cause and Prevention of Cancer
Dr. Otto Warburg
Lecture delivered to Nobel Laureates on June 30, 1966
at Lindau, Lake Constance, Germany

There are prime and secondary causes of diseases. For example, the prime cause of the plague is the plague bacillus, but secondary causes of the plague are filth, rats, and the fleas that transfer the plague bacillus from rats to man. By the prime cause of a disease, I mean one that is found in every case of the disease.

Cancer, above all other diseases, has countless secondary causes. Almost anything can cause cancer. But, even for cancer, there is only one prime cause. The prime cause of cancer is the replacement of the respiration of oxygen (oxidation of sugar) in normal body cells by fermentation of sugar.

All normal body cells meet their energy needs by respiration of oxygen, whereas cancer cells meet their energy needs in great part by fermentation. All normal body cells are thus obligate aerobes, whereas all cancer cells are partial anaerobes. From the standpoint of the physics and chemistry of life this difference between normal and cancer cells is so great that one can scarcely picture a greater difference. Oxygen gas, the donor of energy in plants and animals, is dethroned in the cancer cells and replaced by the energy yielding reaction of the lowest living forms, namely the fermentation of sugar.

In every case, during the cancer development, the oxygen respiration always falls, fermentation appears, and the highly differentiated cells are transformed into fermenting anaerobes,  which have lost all their body functions and retain only the now useless property of growth and replication. Thus, when respiration disappears, life does not disappear, but the meaning of life disappears, and what remains are growing machines that destroy the body in which they grow.

All carcinogens impair respiration directly or indirectly by deranging capillary circulation, a statement that is proven by the fact that no cancer cell exists without exhibiting impaired respiration. Of course, respiration cannot be repaired if it is impaired at the same time by a carcinogen.

To prevent cancer it is therefore proposed first to keep the speed of the blood stream so high that the venous blood still contains sufficient oxygen; second, to keep high the concentration of hemoglobin in the blood; third, to add always to the food, even of healthy people, the active groups of the respiratory enzymes; and to increase the doses of these groups, if a precancerous state has already developed. If at the same time exogenous carcinogens are excluded rigorously, then much of the endogenous cancer may be prevented today.

These proposals are in no way utopian. On the contrary, they may be realized by everybody, everywhere, at any hour. Unlike the prevention of many other diseases, the prevention of cancer requires no government help, and not much money.

Many experts agree that one could prevent about 80% of all cancers in man, if one could keep away the known carcinogens from the normal body cells. But how can the remaining 20%, the so-called spontaneous cancers, be prevented? It is indisputable that all cancer could be prevented if the respiration of body cells were kept intact.

Nobody today can say that one does not know what the prime cause of cancer is. On the contrary, there is no disease whose prime cause is better known, so that today ignorance is no longer an excuse for avoiding measures for prevention. That the prevention of cancer will come there is no doubt. But how long prevention will be avoided depends on how long the prophets of agnosticism will succeed in inhibiting the application of scientific knowledge in the cancer field. In the meantime, millions of men and women must die of cancer unnecessarily.

 

[Aracelis]

Awww...you don't have to go to the Phillipines. I've got a genuine "smudged and blessed" American Indian feather fan that'll fix you right up. And if by some chance that doesn't work, there's a coupla shaamans in the neighborhood. ;^)

[general_re]

Well, do a little ceremony for me, then. And if you know anyone who has a spare ghost dance shirt, I'm always looking ;)

[PatrickHenry]

This thread is nothing! In my la-BOR-a-tory I routinely develop cures for all the world's diseases. But does the greedy establishment recognize my genius? Of course not. The fools!!!! I'll show them. One day I'll show them all!!!!! HAHAHAHAHAHAHAHAHAHA!!!!

[Watchman123]

i have no agenda other than letting people know there is such an advanced photo-dynamic & phto-therapy, Quinoxide treatments out there. I don't have commision over any of this. It does not benefit me. i pray for the day the world will recognize these recent years there already is a treatment for many viral diseases, AIDS, Diabetes, and cancer. I genuinely care for the diseased 7 sufferings who died so needlessly.

[Watchman123]

greenteam 1999.

Actually, this researcher just prefers not to be bombarded with phone calls, some call just to annoy him & take up his precious time. He called me again yesterday & said he wishes to spend time with those who sincerely want to know the truth instead of some hyper-skeptical critic. No, he has not been on Art Bell show. He has though recently written the president & also CDC of his treatment so they could not say noone ever told them. He lives in America. One of the leading M.D. who has been doing this successfully is director of a clinic in mexico. I can tell you that much for now.

[js1138]

Oh Good Grief!! Another miracle shunned by the greedy short-sighted establishment.

This is definitely related to the fact that the U.S. has no SARS deaths while all the more advance nations like Canada and China are having economic catastrophes.

[BossLady]

Yeah...and what about Coral Calcium....that is supposed to be the 'cure-all'!!!!! LOL

[Watchman123]

There is no cure-all supplement. There are supplements which are hyped like super blue green algae, colloidal mineral. Some are potentially harmful, DHEA hormones if your body does not really need it. But I will gladly contrast the side effects of FDA-approved drugs (200,000 die every year from side effects of drugs & medical mistakes-third leading cause of death today. A FACT) and deaths from taking all supplements inclusing Coral Calcium & you name it. Except fror occasionally deaths from Ma Huang & very few supplements, they hardly caused any poisonings , let alone deaths.