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Cholesterol-lowering meds have potential to downgrade COVID-19's threat to that of the common cold
Medicalxpress ^ | JULY 15, 2020 | Hebrew University of Jerusalem

Posted on 07/27/2020 4:33:02 PM PDT by absalom01

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To: Jewbacca

Wonder how the classes differ in mechanisms in that one would help and one not in regards to this virus?


21 posted on 07/27/2020 5:54:49 PM PDT by Moonlighter
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To: absalom01

Pretty early on there was a finding that people on Keto diets where less susceptible to Covid. That would gel with the info presented here.


22 posted on 07/27/2020 5:56:23 PM PDT by Moonlighter
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To: absalom01
Here's the summary from the paper itself: Here we show that the transcriptional response SARS-CoV-2 in primary lung epithelial cells and biopsies of COVID-19 patients is predominantly metabolic. This transcriptional signature was dominated by changes to lipid metabolism and the induction of IRE1 and PKR pathways of endoplasmic stress in a process regulated by several viral proteins. Transcriptional regulatory analysis of these changes reveals small clusters of transcription factors modulating key enzymes in each pathway. The upregulation of glycolysis and the dysregulation of the citric acid cycle was mediated by NFκB and RELA. While the upregulation of fatty acid and cholesterol synthesis showed a more complex control conditionally modulated by ER-stress activated PPARγ, C/EBP, and PPARα. Viral protein ORF3a appeared to interact with all three pathways suggesting both direct and indirect modulation of host metabolism. Finally, we show that PPARα-agonist fenofibrate reversed the metabolic changes induced by SARS-CoV-2 blocking viral replication

Ah, thank God. I was thinking it was going to be more complicated than that.

23 posted on 07/27/2020 6:00:10 PM PDT by VeniVidiVici (m)
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To: absalom01

I have been taking fenofibrate for the last three years and haven’t had an upper respiratory infection of any kind in that time frame. I knew I hadn’t been sick; this is very interesting information.


24 posted on 07/27/2020 6:07:31 PM PDT by Wiser now (Socialism does not eliminate poverty, it guarantees it.)
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To: absalom01

I have been taking fenofibrate for the last three years and haven’t had an upper respiratory infection of any kind in that time frame. I knew I hadn’t been sick; this is very interesting information.


25 posted on 07/27/2020 6:07:51 PM PDT by Wiser now (Socialism does not eliminate poverty, it guarantees it.)
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To: Revel

“There is already an early treatment. It is called HCQ.”

I’m on it, as a preventative. 1 x 200mg per week. Low dose. Talked my PA into it.


26 posted on 07/27/2020 6:13:49 PM PDT by Basket_of_Deplorables (This is all a communist plan!)
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To: absalom01

My cholesterol regimen includes a daily dose of fenofibrate. Yay!


27 posted on 07/27/2020 6:30:47 PM PDT by MrChips ("To wisdom belongs the apprehension of eternal things." - St. Augustine)
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To: absalom01

Not almost. They definitely don’t want to have any cure/vaccine before the elections.


28 posted on 07/27/2020 6:32:14 PM PDT by exinnj
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To: Revel
There is already an early treatment. It is called HCQ. Too bad the democrats have made it impossible to get for most people.

Politicians, actors, entertainers and millionaires seem to have no problem obtaining hcq for preventative treatment. The Proles on the other hand, good luck!

29 posted on 07/27/2020 6:33:44 PM PDT by redcatcherb412
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To: Revel

How dare you offer a cheap, effective and safe treatment when there are hundreds of billions of dollars to be made on vaccines! /s


30 posted on 07/27/2020 6:38:41 PM PDT by Crucial
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To: beethovenfan

“Would Lipitor work also?”

What about Crestor? Or the generic Rosuvastatin?


31 posted on 07/27/2020 6:42:14 PM PDT by ought-six (Multiculturalism is national suicide, and political correctness is the cyanide capsule.)
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To: 21twelve

The funding for that vaccine was dropped after the outbreak was fully contained and never reached epidemic levels.

Though in hindsight...had it be completed, it may have been easier and faster to come up with a vaccine for the current virus.


32 posted on 07/27/2020 7:03:00 PM PDT by Republican Wildcat
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To: 21twelve
"Well, SARS-CoV-1 was 11(?) years ago. No vaccine for that yet. (No vaccine for ANY corona virus for that matter has ever been successful.)"

You got that right. Maybe they will get lucky this time, but I'd rather they quit dissing hydroxychloroquine + zinc and other effective treatments.

33 posted on 07/27/2020 7:06:55 PM PDT by elengr (Benghazi betrayal: rescue denied - our guys DIED - treason's the reason obama s/b tried then fried!)
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To: VeniVidiVici

The mechanism to burn fat only activates once insulin levels in the blood are low, which requires low blood sugar.

If there is any degree of insulin resistance, carbohydrates cannot be burned and therefore insulin levels remain higher, and for a longer period of time.

In fact, high insulin also signals the conversion of carbohydrates into fatty acids to be stored in adipose tissue.

The body is then placed in the horrible position of being loaded with carbohydrates and storing higher and higher amounts of fats, yet the patient is starving.

The virus is basically pushing borderline Type 2 diabetes into full blown cases.

The plain and obvious answer is to place all patients on a no carb/low protein diet (protein can be converted into glucose) until the virus resolves. But doctors have no ability to think about measures other than drugs, so we’re off to the races.

Google “Dr. Jason Fung” for all kinds of interesting facts about obesity, diabetes and carbs.

After experimenting on myself with diet, supplements, and exercise, and losing 30 lbs. of fat in 11 weeks, I’m writing a book about how to exploit these and other mechanisms to boost metabolism, lose weight, stay mentally sharp, and live a longer, healthier life. From the research I’ve done, the biggest factor by far is cutting out sugars, simple starches, and processed foods.


34 posted on 07/27/2020 7:08:24 PM PDT by Go_Raiders (The fact is, we really don't know anything. It's all guesswork and rationalization.)
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To: SanchoP
"SARS-CoV-2? Where did you come up with that?"

COVID-19 is the name of the disease and SARS-CoV-2 is the name of the virus.

35 posted on 07/27/2020 7:09:03 PM PDT by elengr (Benghazi betrayal: rescue denied - our guys DIED - treason's the reason obama s/b tried then fried!)
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To: elengr
"COVID-19 is the name of the disease and SARS-CoV-2 is the name of the virus."

I'd rather just call it the Chicom Wuhan virus.

36 posted on 07/27/2020 7:11:02 PM PDT by elengr (Benghazi betrayal: rescue denied - our guys DIED - treason's the reason obama s/b tried then fried!)
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To: absalom01

Very informative video by brave doctors.

https://www.facebook.com/Breitbart/videos/1376146442759558/


37 posted on 07/27/2020 7:34:50 PM PDT by Dragonfly
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To: BobL

Low carb is best ping!


38 posted on 07/27/2020 7:46:56 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: VeniVidiVici

These occasions are where carbs are being unnaturally stored in lung tissue as fat globules. They can’t be fully used by the body, yet the victim is still pumping them into their mouth.

It seems very likely that a low carb diet would fix this in the same way as the drug.


39 posted on 07/27/2020 7:53:55 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: Go_Raiders

The liver converts both protein and fat into glucose.


40 posted on 07/27/2020 7:56:30 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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