Running both with XPHome without any problems! (as well as AVG anti-virus)
I regularly run Ad-Aware and Spybot, but I recently had a bout with a nasty Cool Web variant that neither program could do anything with, it would just reinstall itself after a system reboot. I used CWShredder and got rid of it and installed and ran Spyware Blaster (a good preventative tool). I also installed all of the recommended security patches from Microsoft and have had no further issues since.
I work in an IT department that supports 500+ users. We run both simultaneously. Our employees have a bad habid of downloading and installing things from the internet. Soon that will be a thing of the past.
Reference.
Now, how do you stop pop-up's?
bump
I highly recommend spyware blaster. I have it on all the machines I manage. It does not run in the background, but it does disable spyware, even if it hasn't been installed yet. In fact it prevents most stuff from being installed and prevents you (or your kids) from seeing the offer to install spyware.