Free Republic

A group of researchers have revealed that adding Vitamin B2 to cells that have been exposed to aging stress increases the mitochondria's ability to produce energy and prevents cell aging. It has previously been shown that the accumulation of old (i.e. senescent) cells in the body causes age-related disorders and whole-body aging. Therefore, there is the potential to prevent and ameliorate age-related disorders and extend people's healthy lifespans using supplements and medicines containing Vitamin B2 to suppress cell senescence. This research group discovered an anti-aging phenomenon whereby the cell's ability to absorb Vitamin B2 is increased in response to stress....

A study in mice has found that stress and tissue damage initiated by angiotensin II, a molecule that is known to increase blood pressure and stiffening in the linings of blood vessels, leads to cellular senescence, a process by which a cell ages and permanently stops dividing but does not die. Importantly, when the researchers eliminated senescent cells from the mice, tissues returned to a normal state in spite of a continued infusion of angiotensin II. We've known that angiotensin II can lead to hypertension and cellular damage, but our findings show that chronic, stress-induced damage due to slightly elevated...

Eliminating old, dysfunctional cells in human fat also alleviates signs of diabetes. The discovery could lead to new treatments for Type 2 diabetes and other metabolic diseases. The cells in your body are constantly renewing themselves, with older cells aging and dying as new ones are being born. But sometimes that process goes awry. Occasionally damaged cells linger. Called senescent cells, they hang around, acting as a bad influence on other cells nearby. Their bad influence changes how the neighboring cells handle sugars or proteins and so causes metabolic problems. Type 2 diabetes is the most common metabolic disease in...

Chronic back pain affects upwards of 15 million adults in the US, racking up billions in healthcare costs and lost work days. Degeneration of the discs that cushion and support vertebrae, a common occurrence of aging, is a major contributor to low back pain. Although a widespread condition, few treatments are available. The findings show how a novel approach to preventing age-related disc degeneration may pave the way for treating chronic back pain. "Once intervertebral discs start to degenerate, there is very little regeneration that happens," says Dr. Risbud. "But our results show that it is possible to mitigate the...

Until recently, few people gave much thought to senescent cells. They are cells that linger in the body even after they have lost the ability to divide. But on Nov. 2, in what could be a landmark experiment in the study of aging, researchers at the Mayo Clinic reported that if you purge the body of its senescent cells, the tissues remain youthful and vigorous. The experiment was just in mice, and it cleared the cells with a genetic technique that cannot be applied to people. Like all critical experiments, it needs to be repeated in other labs before it...

The curious case of the catatonic biogerontologists The SENS strategy as described here purports to have all the characteristics that should make it persuasive: it's detailed, it's thorough and it's all firmly based on established experimental work in the various relevant areas of biology. So, you may well ask, where's the catch? Why, on all the many documentaries on aging that remain so popular, don't my colleagues come out and advocate the work that I advocate? There are three main reasons why most mainstream gerontologists remain so conspicuously absent from the growing band of vocal advocates of the SENS approach...

(Note: The original article is replete with in-text links and visual aids; please visit it in order to access those links.) SENS is a practical, foreseeable approach to curing aging because all the types of metabolic side-effect whose accumulation is (or is even hypothesised to be) eventually pathogenic are amenable to repair (or in some cases obviation, i.e. disruption of the mechanism by which they become pathogenic) by techniques that, according to the experimentalists who have performed the key work on which those techniques build, can (with adequate funding) probably be implemented in mice within a decade or so. There...

(Note: The original article is replete with in-text links; please visit it in order to access those links.) What is Engineered Negligible Sensecence? "It's not a very catchy name, is it?" you may be thinking. Yes, I know -- "Engineered Negligible Senescence" has ten syllables and is not the world's most memorable, or indeed self-explanatory, phrase. But it is a good name for our ultimate goal, honest -- as well as SENS being a catchy acronym. Here's an explanation. I'm afraid it starts with a rather long preamble, but trust me, it's worth it. First, let's be precise: our ultimate...