Free Republic

Enlarge Image Guerrilla tactics. Biologists have created synthetically engineered E. coli (left) that explode and kill pathogenic P. aeruginosa (right). Credit: CDC Like any good military unit, infectious bacteria have access to numerous weapons and efficient communication systems. But like soldiers in the field, they're also susceptible to suicide bombers. Researchers have used the tools of synthetic biology to create an Escherichia coli cell that can infiltrate foreign bacteria and explode, killing off the pathogens along with itself. The project, says bioengineer Chueh Loo Poh of Nanyang Technological University in Singapore, was "inspired by nature," particularly by quorum sensing,...

DEEP in your lungs, there's a battle raging. It's a warm, moist environment where the ever-opportunistic bacterium Pseudomonas aeruginosa has taken up residence. If your lungs are healthy, chances are the invader will be quickly dispatched. But in the mucus-clogged lungs of people with cystic fibrosis, the bacterium finds an ideal habitat. First, the microbes quietly multiply and then they suddenly switch their behaviour. A host of biochemical changes sticks the population of cells together, forming a gluey biofilm that even a potent cocktail of antibiotics struggles to shift. Microbes like P. aeruginosa were once thought of as disorganised renegades,...