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  • Synthetic strategy targets ‘undruggable’ small RNAs

    02/13/2014 9:50:51 PM PST · by neverdem · 7 replies
    Chemistry World ^ | 12 February 2014 | Manisha Lalloo
    Molecules can now be designed to target specific small RNAs, opening up a new way to investigate and treat disease © ShutterstockChemists in the US have found a way to predict small molecules that can target short pieces of RNA involved in some diseases, such as cancer. The team’s approach has already met with some success, throwing up a molecule that interferes with a microRNA involved in cancer. This opens up the possibility of treating diseases via a target traditionally seen as ‘undruggable’.MicroRNAs are non-coding lengths of RNA, around 20 nucleotides long, that act as dimmer switches in cells, turning...