Jonathan Demme, the Oscar-winning filmmaker who observed emphatically American characters with a discerning eye, a social conscience and a rock ’n’ roll heart, achieving especially wide acclaim with “The Silence of the Lambs” and “Philadelphia,” died on Wednesday at his home in Manhattan. He was 73. His publicist, Leslee Dart, confirmed the death. Mr. Demme disclosed that he had cancer in 2015. Mob wives, CB radio buffs and AIDS victims; Hannibal Lecter, Howard Hughes and Jimmy Carter: Mr. Demme (pronounced DEM-ee) plucked his subjects and stories largely from the stew of contemporary American subcultures and iconography. He created a body...