One was a middle-aged man who refused to get into the shower. The other was a teenager who was afraid to get out. The man, Leonard, a writer living outside Chicago, found himself completely unable to wash himself or brush his teeth. The teenager, Ross, growing up in a suburb of New York, had become so terrified of germs that he would regularly shower for seven hours. Each received a diagnosis of severe obsessive-compulsive disorder, or O.C.D., and for years neither felt comfortable enough to leave the house. But leave they eventually did, traveling in desperation to a hospital in...