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Merck has a potential blockbuster in anacetrapib, an experimental cholesterol drug that increases HDL, or “good” cholesterol even as it lowers LDL, the “bad” cholesterol. The drug could potentially have sales of more than $1 billion a year, John Boris, an analyst at Citigroup, wrote in a note to investors on Wednesday. But don’t hold your breath. Cardiologists, patients and investors will have to wait until at least 2015 to find out whether anacetrapib protects the heart by reducing heart attacks and other cardiovascular problems, Merck said. Anacetrapib works by inhibiting an enzyme called CETP, which is involved in transforming...

The best blood pressure range for patients with diabetes and heart disease appears to be slightly higher than what is recommended for healthy adults, according to a study in today's Journal of the American Medical Association. In fact, the blood pressure range considered normal - less than 120 systolic and less than 80 diastolic - may actually be risky for those with a combined diagnosis of diabetes and coronary artery disease, report University of Florida researchers from the International Verapamil SR-Trandolapril study, known as INVEST. Optimum systolic blood pressure levels should be between 130 and 140 for patients coping with...

With the government’s blessing, a drug giant is about to expand the market for its blockbuster cholesterol medication Crestor to a new category of customers: as a preventive measure for millions of people who do not have cholesterol problems... --snip-- But critics said the claim of cutting heart disease risk in half — repeated in news reports nationwide — may have misled some doctors and consumers because the patients were so healthy that they had little risk to begin with. The rate of heart attacks, for example, was 0.37 percent, or 68 patients out of 8,901 who took a sugar...

GAINESVILLE, Fla. — For patients with diabetes and heart disease, less isn't always more — at least when it comes to blood pressure. New data show an increased risk of heart attack, stroke or death for patients having blood pressure deemed too high — or too low, according to Rhonda Cooper-DeHoff, Pharm.D., an associate professor of pharmacy and medicine at UF. She reported her findings today (Sunday, March 14) at the American College of Cardiology's 59th annual scientific session in Atlanta. She recommends raising the systolic bar above 120 for blood pressure in patients with diabetes and coronary artery disease,...

If you're taking a daily aspirin for your heart, you may want to reconsider. For years, many middle-aged people have taken the drug in hopes of reducing the chance of a heart attack or stroke. Americans bought more than 44 million packages of low-dose aspirin marketed for heart protection in the year ended September, up about 12% from 2005, according to research firm IMS Health. Now, medical experts say some people who are taking aspirin on a regular basis should think about stopping. Public-health officials are scaling back official recommendations for the painkiller to target a narrower group of patients...

Deleting a non-coding region leads to narrowing of arteries in mice. Researchers have made headway in working out why a section of junk DNA — the 98% or so of the genome that does not code for proteins — raises the risk of at least one form of heart disease. About one in five deaths in the United States results from excessive build-up of fatty plaques inside arteries supplying blood to the heart — known as coronary artery disease (CAD). In 2007, genome-wide association studies1,2 on thousands of participants linked a non-coding stretch of chromosome 9p21 with the disease, and...

Imagine a treatment that could build bones, strengthen the immune system and lower the risks of illnesses like diabetes, heart and kidney disease, high blood pressure and cancer. Some research suggests that such a wonder treatment already exists. It’s vitamin D, a nutrient that the body makes from sunlight and that is also found in fish and fortified milk. Yet despite the health potential of vitamin D, as many as half of all adults and children are said to have less than optimum levels and as many as 10 percent of children are highly deficient, according to a 2008 report...

Risk: Stressed people are twice as likely to have furred arteries Getting stressed really is bad for your heart, according to new research. For years, stress has been linked to heart attacks and other heart complaints but with very little medical evidence to back it up. Now a major trial by doctors at University College London has proved for the first time that people who get stressed are also likely to have heart disease. The study involved 514 men and women, with an average age of 62. None had signs of heart disease...

President Obama’s budget guru has a secret love child — with the woman he jilted before hooking up with his hot new fiance, The Post has learned. White House budget director Peter Orszag’s ex, shipping heiress Claire Milonas, gave birth to little Tatiana Zoe in New York Nov. 17. That was just six weeks before Orzsag and ABC news babe Bianna Golodryga gleefully announced their engagement on national TV and in the press. Orszag and Milonas, the daughter of New York-based Greek shipping magnate Spiros Milonas, were a serious item when he met the stunning Golodgryga at the White House...

(Boston) - Researchers from Boston University School of Medicine (BUSM) in collaboration with researchers from Lahey Clinic Northshore, Peabody, Mass., believe that androgen deficiency might be the underlying cause for a variety of common clinical conditions, including diabetes, erectile dysfunction, metabolic syndrome and cardiovascular disease (CVD). These findings appear in the September/October issue of the Journal of Andrology. Androgens are a steroid hormone, such as testosterone, that controls the development and maintenance of male characteristics. In a number of studies, androgen deficiency has been linked to an increased mortality in men. Testosterone (T) is an anabolic hormone with a wide...

A deficiency of the sunshine vitamin may worsen plaque accumulation in vessels of diabetes patients Vitamin D deficiency may exacerbate the excess heart disease risk that people with type 2 diabetes face, a new study in the Aug. 25 Circulation suggests. In lab tests, researchers demonstrate that immune cells with very low vitamin D levels turn into soggy, cholesterol-filled baggage that can become building blocks of arterial plaques. Carlos Bernal-Mizrachi, an endocrinologist at Washington University School of Medicine in St. Louis, and his colleagues found that people with diabetes seem more susceptible than nondiabetics to the negative cardiovascular effects attributable...

Contact: Alisa Zapp Machalekalisa.machalek@nih.gov 301-496-7301NIH/National Institute of General Medical Sciences Gene variant linked to risk of stroke and heart attack for those on Plavix NIGMS media availability WHAT: A new study reports that a gene variant carried by about a third of the population plays a major role in this group's response to an anti-clotting medicine, clopidogrel (Plavix). People with the variant produce a defective version of the CYP2C19 enzyme and are less able to activate the drug.One of the world's best-selling medicines, Plavix prevents blood clots in people with heart disease by keeping platelets from sticking together. But about...

COPENHAGEN — Rheumatoid arthritis and two other rheumatic diseases are as strong as diabetes as risk factors for cardiovascular disease, prompting a European League Against Rheumatism task force to issue the group's first consensus recommendations for managing cardiovascular risk in patients with rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. “In our view, rheumatoid arthritis [RA], ankylosing spondylitis [AS], and psoriatic arthritis [PsA] should be seen as new, independent cardiovascular risk factors,” Dr. Michael T. Nurmohamed said at the annual European Congress of Rheumatology. “Very importantly, the risk is comparable to type 2 diabetes,” added Dr. Nurmohamed, a rheumatologist at the...

Enlarge ImageEvolving evidence. In a massive study, C-reactive protein didn’t boost the risk of heart attacks.Credit: Wikipedia A new study may be the last word in a controversy that's plagued cardiovascular disease research for years: whether a marker of inflammation known as C-reactive protein (CRP) drives heart attacks and strokes. In a survey of more than 128,000 people, researchers have found that genes that raise CRP levels don't make cardiovascular disease more likely. Although the study arrives at the same conclusion as earlier work, its massive size makes it statistically the most powerful test yet of this question and...

TUESDAY, (HealthDay News) -- Injecting bone marrow cells into the heart's muscular wall restored blood flow to hearts with blocked arteries for which conventional treatments had proven ineffective, Dutch physicians have reported. "I think this is very good news for patients who are at the end of the line and have no options left," said Dr. Douwe E. Atsma, an interventional cardiologist at Leiden University Medical Center and an author of the study, which appears in the May 20 issue of the Journal of the American Medical Association. The 50 people in the study, 43 of them men, were experiencing...

SAN DIEGO — The Institute of Medicine is reviewing its 1997 guidelines for vitamin D intake, and will likely recommend increased supplementation when new guidelines are published in 2010. There is a growing consensus that currently recommended intakes—200 IU per day for individuals under age 50 and 400 IU for those aged 50-70—are too low, said Connie Weaver, Ph.D., director of the department of food and nutrition, at Purdue University, West Lafayette, Ind. A recent analysis of data collected by the National Health and Nutrition Examination Survey (NHANES) during 1988-1994 and 2001-2004 even suggests that an epidemic of vitamin D...

Researchers suggest a huge bump in recommended daily levels as the vitamin's benefits extend to helping fight diabetes, cancer and cardiovascular disease. Vitamin D's star is on the rise and physicians who have studied it say it's about time.Recent research has found that higher D levels are beneficial in fighting ills ranging from colds to cancer. And, on March 26, the Institute of Medicine's Food and Nutrition Board began reviewing those studies and many others with an eye to revising the recommended dietary intake of vitamin D and its close companion in maintaining bone health -- calcium. A report is...

July 22, 2008 — A new fissure is creeping through the cardiology community, dividing those in favor of risk-factor screening and prevention on one side from those who advocate early screening for the disease itself. The debate is playing out online July 29, 2008 in the Journal of the American College of Cardiology, with Drs Jay Cohn and Daniel Duprez (University of Minnesota Medical School, Minneapolis) arguing in favor of early identification of disease through simple screening tests, and Drs Philip Greenland and Donald Lloyd-Jones (Northwestern University, Chicago, IL) urging clinicians to focus on risk factors and steer clear of...

Apart from its sadness, Tim Russert’s death this month at 58 was deeply unsettling to many people who, like him, had been earnestly following their doctors’ advice on drugs, diet and exercise in hopes of avoiding a heart attack. Mr. Russert, the moderator of “Meet the Press” on NBC News, took blood pressure and cholesterol pills and aspirin, rode an exercise bike, had yearly stress tests and other exams and was dutifully trying to lose weight. But he died of a heart attack anyway. An article in The New York Times last week about his medical care led to e-mail...

Given the great strides that have been made in preventing and treating heart disease, what explains Tim Russert’s sudden death last week at 58 from a heart attack? The answer, at least in part, is that although doctors knew that Mr. Russert, the longtime moderator of “Meet the Press” on NBC, had coronary artery disease and were treating him for it, they did not realize how severe the disease was because he did not have chest pain or other telltale symptoms that would have justified the kind of invasive tests needed to make a definitive diagnosis. In that sense, his...