Free Republic

Quite a few women like this exist. The problem is, we're all married.

I’m not convinced.

When I lived in France for a year, someone asked me if some tourists were speaking English. They were not. They were speaking German. The French woman could not tell the difference.

I think that listening to Dutch would give a pretty good idea of what English sounds like to a non-speaker, also. Dutch is the closest to English of any language.

Whether or not a woman is immune to a pathogen has nothing to do with SIDS. SIDS has always killed babies, since long before humans ever thought of even rudimentary forms of vaccination.

Thus, asking whether a bereaved mother had a vaccination prior to her child’s death is completely unnecessary and irrelevant.

The immune system responds pretty much the same way to any vaccine, whether it’s an influenza, measles, tetanus, or coronavirus vaccine. The immune system responds to vaccines the same way it responds to pathogens—except that its response to vaccines is very limited because no real pathogen is present. And, as I already said, the woman’s immune response doesn’t affect her baby (except that she might pass protective antibodies to the baby through the placenta or her milk, helping to protect the baby against deadly pathogens).

Think of it this way: if immunity against SARS-CoV-2 is deadly, then everyone who has had Covid is already dead.

We're still dangerously close to those levels.

I've tried to point out to carbon alarmists the central role of atmospheric CO2 in supporting life on this planet. When plants die off because of insufficient CO2, this means that everything that depends on plants also dies off from lack of carbon. You can't remove a ton of CO2 from the air without decreasing the existing biomass by a ton.

The answer I've received from alarmists is that it's okay for plants requiring a relatively high concentration of CO2 to die off, because there will still be other plants that can survive on lower CO2 concentrations. They simply cannot (or refuse to) understand the link between CO2 and total biomass.

Well, it looks like some climate alarmists have discovered a tiny sliver of the immense carbon cycle that all life depends on.

It seems they still haven’t discovered the fact that all life is formed from carbon dioxide. Let’s hope they discover this before they put too many carbon sequestration schemes in place and start causing mass extinctions.

LOL.

I love how the fearmongers keep pushing back the deadline for all of us vaccinated people to die. First, it was within two years. Now, it’s within three to five years.

The first Covid vaccines were administered Dec. 14, 2020—almost three and a half years ago.

Over 80% of the population has received at least one dose of vaccine. Do you see 80% of the population dropping dead yet?

BTW, “mRNA” does not stand for “modRNA” (which also is not a real term). “mRNA” stands for “messenger ribonucleic acid” which is a molecule that carries information from the genome to the protein factory. This information contains instructions on how to make a specific protein. The vaccine mRNA contains instructions on how to make SARS-CoV-2 spike protein, but there are countless other mRNAs. The human body produces over 100,000 different mRNAs.

All mRNA is modified during the biological process of production. The mRNA contained in the vaccine contains a substitution of the nucleotide uracil with a similar naturally occurring nucleotide, pseudouracil. This substitution helps to hide the spike mRNA from the immune system so that it doesn’t get destroyed before it can enter an immune system cell and direct synthesis of spike protein. After a protein molecule is made, enzymes in the cell destroy it. An mRNA might escape destruction long enough to direct the production of one or more additional protein molecules, but it can’t escape forever. The half-life of mRNA in a cell is typically a few hours. Scientists consider a substance gone once six half-lives have passed. This means that an mRNA with a half-life of five hours is gone within two days.

There are a couple of ironies intrinsic in this particular line of antivax misinformation.

One, is that if the vaccine mRNA were chemically different from any other mRNA, it simply would not work. The protein factory (aka “ribosome”) can only use mRNA that is made from naturally occurring nucleotides.

Two, is that if the vaccine mRNA had some magical property that kept it from being destroyed by cellular enzymes, it would become a “true” vaccine in the antivax false “definition” of vaccine. Because professional antivaxxers try to convince people that a vaccine is only “real” if it protects everyone forever, an indestructible mRNA would direct the production of spike forever, in turn causing the immune system to keep making antibodies against it forever. Thus, it would be a “true” vaccine. But this is not the case.

How long immunity lasts is determined by how well the immune system remembers a specific pathogen. It simply does not remember coronaviruses very well, which is why immunity against coronaviruses always wears off after a few months. It does not remember the SARS-CoV-2 coronavirus any better than it remembers other coronaviruses. It is actually rare for the immune system to remember a pathogen forever.

Oh, my. The original source of this blog is “Natural News,” a well-known website run by a self-proclaimed health “guru” who knows nothing about actual medicine.

The notion of “turbo cancers” is completely fabricated by antivax propagandists. There is no such thing as a “turbo cancer.”

Cancers take years to develop. Even one of the most potent carcinogens known—sub-lethal doses of ionizing radiation—does not cause cancer immediately, but several years down the road.

In order for a cancer to develop, there must be direct damage to the DNA. Such damage occurs randomly during cell division (but our DNA repair enzymes almost always fix that). It occurs as a result of exposure to ionizing radiation. It occurs as a result of exposure to UV light. And it occurs as a result of chemicals that physically interact with the DNA.

A vaccine is not radioactive, contains no UV light, and contains no chemicals that interact with DNA. It is physically impossible for a vaccine to cause cancer. This is true of every vaccine, including mRNA vaccines. mRNA only exists in the cell’s cytoplasm. The cell’s DNA is in the nucleus and mitochondria. The physical separation of mRNA and DNA makes it impossible for mRNA to interact with DNA. Furthermore, the fact that the vaccine contains the mRNA for a virus protein makes it unlikely for the mRNA to interact with the DNA even if they were in the same physical location. This is because RNA can only interact with DNA if it has the same nucleotide sequence. Human DNA does not contain the sequence of coronavirus spike protein.

During the peak of the pandemic, people were going to the doctor less because a) the health care system was swamped with Covid patients, and b) they were afraid of being exposed to Covid at a health care facility. This caused a drop in the number of cancer diagnoses during this time. After things calmed down (we’re down to “only” a couple of thousand Covid deaths per week), people returned to the doctors for check-ups. And what happened? All of the people whose cancers had been missed during the pandemic were now being diagnosed. And because they are being diagnosed later, the cancers are more advanced.

How about let’s stop posting unscientific fear-mongering here. Vaccines are one of the most effective and natural health interventions ever invented. They use our body’s own natural processes to protect us from disease.

Perpetual energy machines are physically impossible.

For this reason, the patent office will not award patents to any device that they determine is a “perpetual motion machine.”

Meanwhile, people for whom the swastika is a religious symbol are trying to restore its reputation after the German National Socialists coopted it for their purposes some 90 years ago.

I saw swastikas used as a design motif in Mongolia. I bought a t-shirt that has a tiny swastika on the back. I bought it because it has a very nice artwork of a Mongolian warrior and warhorse on the front. No one has ever noticed the swastika.

In respect for the people for whom the swastika is a religious symbol of peace, I would not recommend that modern leftists who espouse many of Hitler’s values use that symbol. Of course, the right has never embraced Hitler’s socialist ideas.

Here is graphene oxide:

Notice how black it is. (The powder, not the jar.)

Here are several vials of Covid vaccines:

Notice how clear and colorless the liquid in them is.

No, these colorless liquids do not contain black graphene, which would make them black.

Let's stop posting baseless claims, mkay?

My first comments are on the study itself. First of all, the article is not indexed in Pubmed, which raises doubts as to its credibility. As for the author Brigitte König, her PhD is in Medical Microbiology and Infectious Immunology; from her publications indexed in Pubmed, it appears that she works using cell biology techniques and that she has little to no experience in molecular biology. The other author only has a comment indexed in Pubmed; this is the scientific version of a letter to the editor.

The lack of expertise in molecular biology is significant. There are things a molecular biology would consider, look for, and control for that someone who is not trained in molecular biology would not even think of. For example, the statement that "DNA target sequence is less than just 1% of the originally added DNA template" is irrelevant. If a template is 20,000 nucleotides long and the PCR target is 1% of that, 200, the target is still specific to that target and no other. Each template molecule contains that target; the quantity of PCR product is, therefore, directly proportional to the quantity of template.

In addition, the article Methodological Considerations Regarding the Quantification of DNA Impurities in the COVID-19 mRNA Vaccine Comirnaty® contains no "Materials and Methods" section. This is crucial for any scientific research publication, as this is the section which states exactly what the researchers did and which manufacturers supplied their reagents and equipment. This information allows other researchers to duplicate their results. All they did was present some graphs which they claim show the quantity of DNA and RNA measured in each sample, but we really don't know since we don't know their methodology.

Next, the patent does not contain any "admissions" as claimed in the Infowars blog.

Removal of DNA fragments in mRNA production process.

The term "insertional mutagenesis" appears nowhere in the patent. It appears that Infowars used that term to imply that the vaccine is capable of causing mutations in the recipients and that the patent holder is aware of this, but this is not the case. Assuming that some intact plasmid is in the vaccine, the worst that could happen would be that the cell could make a bit more mRNA before destroying the plasmid DNA. The patent does describe various types of mutations, but that's a far cry from describing something that is capable of getting into human cells and altering DNA. (You don't need DNA to alter DNA anyway. Smokers get dosed with DNA-altering chemicals every day. And the UV in sunlight is notorious for altering DNA.)

Finally, as for Infowar's claim that "It had already been discovered that DNA in the mRNA COVID vaccines includes a variety of leftover genetic material, including the simian virus 40 cancer-promoting gene and plasmid DNA sequences from E.coli," this is based entirely on misrepresentation of the science involved.

A plasmid is a small piece of DNA which researchers use to cause cells to produce RNA and proteins they don't normally make. We use E. coli to grow the plasmids. In order for the plasmid to grow in E. coli, it has an antibiotic resistance gene and an "origin" which directs the E. coli to make more copies of the plasmid. We can put a gene into the plasmid; in the case of vaccine, it is a spike protein gene. In order for a gene to function, it must have instructions. One of these instructions is the promoter element, which tells the RNA polymerases (enzymes) to attach and start making RNA. For the vaccine, the SV40 promoter element was used, since it functions in cells with nucleuses (like mammalian cells). The fact that this small instruction came from the SV40 virus does not mean that an oncogene is present. The Infowars blog took a huge and unjustified liberty with language when it called the SV40 promoter a "simian virus 40 cancer-promoting gene." A promoter isn't a gene.

Remember that university STEM textbook reading list I provided you a while back (with helpful links to their Amazon.com listings)?

E.g. NLPs introducing the mRNA to cells which don't express the ACE2 receptor and thus were never envisaged as being a target if the jabs.

Well, perhaps if you would start studying those books, you would understand why natural language processing--for which "NLP" is an acronym--doesn't have a biological function.

Maybe you were trying to abbreviate "nanolipid particles." The actual term is "lipid nanoparticles" and it does not have an acronym, if this Nature review article is any clue: Lasting impact of lipid nanoparticles. Not that you would know it, but when scientists use scientific terms that have an acronym, they spell out the term the first time it appears in the manuscript, then use the acronym for the rest of the article.

It literally is irrelevant that the vaccine nanoparticles are not endocytosed by cells that express the ACE2 receptor. ACE2 receptor binding with subsequent endocytosis is necessary for the virus to establish an infection. But it is not needed for the functions of antigen presenting cells that mediate the adaptive immune response.

The vaccine was *always* intended to be analyzed by immune system cells. No one ever designed the vaccine to target the cells that are targeted by viruses. The purpose of a vaccine is not to mimic the activity of a pathogen on the body; it is to cause the immune system to respond as if there were a pathogen present.

Are the spike proteins whose construction within the cell, simple enough that they will assume the physiologically active, desired conformation, solely br virtue of the amino acid sequence called for by the mRNA? Or do they require helper proteins to reach the "real" 3D structure?

Whatever host proteins within the endoplasmic reticulum assist the wild-type spike protein to fold correctly during infection will also help the vaccine spike protein fold correctly. Typically, the endoplasmic reticulum is the site of considerable protein modification, such as glycosylation, ubiquitination, methylation, etc. In order for the immune system to properly learn to recognize the spike protein, the vaccine spike must be naturally modified in the same way as the virus spike. If these modifications do not happen, then the immune system will not produce antibodies that recognize the spike on the surface of a virus because the protein they are targeting does not have the physicochemical properties of the wild-type spike.

SARS-CoV-2 Spike Protein Post-Translational Modification Landscape and Its Impact on Protein Structure and Function via Computational Prediction.

Or, for that matter, frame shifting based on ghe modified mRNA?

I'm not sure what "ghe modified mRNA" is. But the effect of frame-shifts is usually to cause the production of short non-functional proteins (which are quickly destroyed) or to prevent protein synthesis at all. It is possible that there are some frame-shifted mRNAs in the vaccine, due to natural errors that occur during the process of translation (making an RNA copy of a sequence from the genome). But they won't have an effect. The ribosome can also shift during translation, leading to the production of altered proteins. Frame shifts happen quite frequently; this is why organisms have evolved mechanisms to identify and destroy incorrect proteins. There are, of course, no intentional frame-shift mutations in the mRNA, since the purpose of the mRNA is to function like the virus mRNA.

Vax trolls don't even have the ghost of a hint of a putative mechanism for the bold clots and myocarditis following the jabs

The blood clots were associated with the adenovirus-based vaccines, the AstraZeneca and the Johnson & Johnson, both of which have been pulled from market. The risk of blood clots from either of those vaccines was low, but still high enough above the background rate of blood clots for there to be concerns about vaccine safety. I suspect that since the blood clots were only observed following vaccination with the adenovirus vectors, the issue was due to the adenovirus backbone, not the DNA copy of the spike gene that had been inserted into the adenovirus.

As for the myocarditis, it is immune-mediated. Most often, it is triggered by infections, but it can also be triggered by other inflammatory processes. (Inflammation is an immune system function.) Here is a review on the current (as of 2020) understanding of myocarditis:

Myocarditis and inflammatory cardiomyopathy: current evidence and future directions.

Basically, if a pathogen can cause a condition like myocarditis, there is a small possibility that the vaccine against that pathogen will trigger myocarditis. This is because the immune response to a vaccine is so similar to the immune response to a pathogen.

The problem is that you are writing at a 6th grade level for people you take to be bewildered breeland peasants: to the point that you think people can't read and comprehend outside of their formal training: e.g. the CEO of Pfizer is a veterinarian, the CEO of Moderna was a Chem Engineer, and Francis Collins had a PhD in physical chemistry.

First of all, you yourself have complained that the scientific/medical research articles I have posted in the past were gibberish. After that complaint, do you really think I'm going to provide you the same highly technical descriptions I would give to people who hold PhDs in STEM fields similar to my major? No, writing at a sixth grade level is a tool to communicate to people who do not have a STEM education.

And don't feel bad. I was advised once, when I had to write a report of scientific research for Congress, to keep it at the sixth-grade level so that they could read it. On this forum, I actually write at above a sixth grade level.

FYI, your mentions of CEOs and Francis Collins really don't make the point you seem to think it makes. Even Nobel Prize winners can be spectacularly wrong when it comes to areas outside of their fields of expertise.

But you are projecting your own ineptitude and ignorance when you imply that only those with a formal degree in a field are capable of understanding it.

Really? When did I imply that? I have, in fact, spoken with quite a few lay people who, through their own efforts, have learned the science and can hold their own quite well in a highly technical discussion. But that's the thing--they actually read real scientific material, which is not the type of stuff you see on antivax sites.

And you ignore the fact that anyone who had a loved one drop dead or get turbo cancers after the clot shots, is not going to be assuage by your kind loftily dismissing them as kooks or hysterically imagining things because they JUST. DON'T. UNDERSTAND. SCIENCE.TM

Why should I give any scientific credence to things that were outright invented by professional antivaxxers (e.g. "turbo cancer") or deliberately presented out-of-context by said antivaxxers with the intent of convincing people that the vaccine is worse than the disease? I know full well that people who don't understand science are their primary targets for their propaganda. People who understand science or at least have enough of an understanding recognize the competence of those who make science their career.

In my home, since I am retired now.

And if you really expect me to give out identifying information, forget it. I'll provide it just as soon as you and all those spreading antivax propaganda give their personal contact information.

You worked for Fauci, correct?

Never met him.

Fauci's job was to correlate all of the scientific data from scientists all over the world and present it to the public in a comprehensible format.

I've provided similar information to other government officials, but never to Fauci, to my knowledge.

The article quotes her as complaining that she had to buy two seats.

She is too heavy to move her own body, yet she expects someone else to move it for her?

This should give her a clue. Maybe it’s time to shed that tonnage. I’ve heard that semaglutide helps people lose weight. It seems to be that magical weight loss pill that everyone always wants.

We were seated apart on a flight (cheaper tickets for not sitting together). I overheard a woman say, when she saw my son heading for the empty middle seat next to her, "Oh, thank God, it's the skinny guy!"

So, how did American armadillos catch it from European squirrels?

This is an interesting topic to look into!

I will try to be as diplomatic as possible.

When people post anecdotal stories of a major medical condition that was diagnosed right after vaccination, and that medical condition is not associated with immune system function, I am highly skeptical.

Immune system function has been studied for over 200 years, since the first vaccine became available. By now, infectious disease and immunology specialists have a pretty good idea of what kinds of side effects occur following immune system challenge with an immunogen.

I have read several anecdotal stories which are frankly unbelievable. And I will not say more on this subject.

Ugh.

Expertise in cardiology does not confer expertise in immunology, infectious disease, vaccinology, or any other field in which people who develop vaccines work.

I don't pretend to be an expert in cardiology, since that is not what my PhD studies focused on. My PhD studies and subsequent career focused on immune system function, especially the process of antibody production following antigen challenge.

Many antivax scammers use their doctorate level degrees to fool people into thinking they have expertise that they don't. McCullough does this. So does Naomi Wolf, PhD in English Literature. So have several other MDs whose specialties were in fields like orthopedic medicine.

People who are experts in infectious disease do not typically spread antivax nonsense.

Wow, that is quite the success story. Congratulations!

I have read recent reports that people must continue to take the semaglutide in order to maintain the weight loss permanently. But is that really a problem if you tolerate the drug well?