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Ebola patient receives experimental treatment in Dallas hospital
Dallas Morning News ^ | 12:47 pm on October 6, 2014 | Sherry Jacobson

Posted on 10/06/2014 11:08:08 AM PDT by palmer

Thomas Eric Duncan, the Liberian national who is fighting a severe Ebola infection in Dallas, is getting an experimental treatment, the hospital announced Monday.

The drug is an investigational medication, brincidofovir, for Ebola Virus Disease.

Chimerix, Inc., a biopharmaceutical company today announced that brincidofovir has been provided for potential use in patients with Ebola Virus Disease. ...

(Excerpt) Read more at thescoopblog.dallasnews.com ...


TOPICS: Business/Economy; Government; US: Texas
KEYWORDS: brincidofovir; chimerix; ebola; ebolatreatment; thomasduncan; uspatientzero
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To: GrandJediMasterYoda
banning all flights from West Africa?

He didn't arrive on a flight from West Africa.

The ban has to be on passports, not flights.

41 posted on 10/06/2014 11:45:14 AM PDT by cynwoody
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To: Grams A; Black Agnes

Yeah. And now his liver has failed, probably from all the drugs. So I guess now, pending his recovery, he’ll get a liver transplant.
Don’t think he’s going to recover though. We will see.


42 posted on 10/06/2014 11:48:58 AM PDT by Vinnie
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To: Lion Den Dan

I read that yesterday! That he had died. What’s going on?


43 posted on 10/06/2014 11:48:58 AM PDT by Arlis
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To: palmer; dan on the right; Black Agnes
palmer:" I have no idea how people manage to fight it off."

The disease overwhelms the immune system
The doctor in Africa used AIDS suppression medication,since he had no access to other medications.
Ebola seems to have more severe reactions to 14 - 39 year olds, and the severity may be related increased immune sytems ( increased self-destruct system ?)
Best way to fight it off is: Quarantine, isolation, knowledge of the disease(how,where,)anti-viral controls (ie: water/bleach @10 partswater/1 part bleach), avoidance.
If contracted: analygesics, anti-Diarrhea medication, electrolite replacement, hydration , saline IV's, fever suppression, etc.

44 posted on 10/06/2014 11:49:48 AM PDT by Tilted Irish Kilt
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To: Vinnie

Actually liver failure is what ebola does. It’s one of the organs the ebola preferentially attacks.


45 posted on 10/06/2014 11:51:17 AM PDT by Black Agnes
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To: Arlis

Just one source said he was dead (Israeli newspaper). Didn’t get confirmed.


46 posted on 10/06/2014 11:51:47 AM PDT by palmer (This comment is not approved or cleared by FDA)
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To: Arlis; Lion Den Dan
Arlis:" I read that yesterday! That he had died. What’s going on?"

False report alledged via Reuters

47 posted on 10/06/2014 11:53:23 AM PDT by Tilted Irish Kilt
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To: Black Agnes
You guys are good - yes its another acyclovir but with a tail. Which is supposed to do what?

I heard some doctor is using retrovirals - with a ~70% mortality rate you dont need much of a sample size.

48 posted on 10/06/2014 11:55:22 AM PDT by corkoman
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To: Tilted Irish Kilt

Np it came from Israel news first.


49 posted on 10/06/2014 11:56:11 AM PDT by caww
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To: corkoman

No clue about the tail.

But the Liberian doc said acyclovir didn’t work. A quick glance at the structure shows a 5 member ring joined to the 6 member ring. May inhibit binding to the substrate.


50 posted on 10/06/2014 11:56:52 AM PDT by Black Agnes
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To: palmer

“He is now receiving an investigational medication, brincidofovir, for Ebola Virus Disease,” hospital spokeswoman Candace White said in a tweet.

The announcement that he is now being treated with an experimental anti-viral medication called brincidofovir comes the same day that the Food and Drug Administration approved its use in experimental cases.

Brincidofovir is produced by Chimerix, a Durham, North Carolina-based company and was approved through an Emergency Investigational New Drug Applications program by the FDA.


51 posted on 10/06/2014 11:57:09 AM PDT by caww
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To: Vinnie
What do you think the dollar amount is for his treatment so far? $150,000 ? bet that’s not far off.

LOL! $100,000.00/day EASY. If he survives, it will cost a couple of million for a month stay on the LOW side.

52 posted on 10/06/2014 11:58:47 AM PDT by DCBryan1 (No realli, moose bytes can be quite nasti!!)
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To: Black Agnes

Makes sense. The virus likes to breed in endothelial cells.


53 posted on 10/06/2014 11:58:54 AM PDT by palmer (This comment is not approved or cleared by FDA)
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To: cynwoody

Oops yeah that’s right, I think he took a flight from Brussels. Which reminds me: What is Belgium doing about that? For all we know he could have shook hands with 100 people.


54 posted on 10/06/2014 12:00:28 PM PDT by GrandJediMasterYoda (Obama Will Say 'War on Women' But Not 'War on ISIS)
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To: palmer

I worry about the long-term effects of a cure that might cause the disease to mutate into something that spreads more easily.


55 posted on 10/06/2014 12:04:21 PM PDT by grania
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To: US Navy Vet

My dad always said there was only one way to cure an egg-sucking dog. With a .22 rifle. Anyone as selfish as this a**hole to put an entire nation at risk to save self, if he does recover should be put in a work camp for the rest of his days to pay back for his treatment. Worthless heathen will be death of this republic. The whole world bitches about how awful Americans are but we are who the fools run to first. How is that for irony? Like the stupid hollyweird crowd howls about the conservative patriots who make this nation great but if it wasn’t for us the little commie freaks wouldn’t have a haven to make their pornographic, immoral filth for the big screen would they?


56 posted on 10/06/2014 12:05:16 PM PDT by Cats Pajamas (Wonder what Slick and Cankles did with the rent a dogs now they have grandbaby for optics?)
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To: HereInTheHeartland

Only for U.S. Citizens on Obamacare.


57 posted on 10/06/2014 12:05:37 PM PDT by Rusty0604
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To: Vinnie

“I heard his sister bitch’n about him not getting good treatment”

I wish I could say what I think about that .


58 posted on 10/06/2014 12:08:35 PM PDT by Rusty0604
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To: Black Agnes
What with the CURE for HepC - hello this is a freaking miracle - I was hoping for Gil, BMS, or Achillion to go after HPV.

But I have been informed that, no, not anytime soon.

HPV is a tough nut to crack.

I am wagering that no one has the foggiest how long it will be to get a decent Obola treatment. These nucleo experimentals may not work.

59 posted on 10/06/2014 12:09:00 PM PDT by corkoman
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To: dan on the right
ZMapp is a monoclonal antibody, a much more complex thing than lamivudine or brincidofovir, which are single molecules.

ZMapp is grown using genetically engineered tobacco plants. The plants are infected with a virus that has been modified to produce ZMapp when it replicates. The leaves are then ground up and the antibodies extracted.

The production cycle is a few months.

It would be better to save the money needed to deploy US troops to West Africa and instead spend it on making sure the West African docs have all the lamivudine and brincidofovir they need.

60 posted on 10/06/2014 12:09:20 PM PDT by cynwoody
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