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Opioids, like morphine, are effective painkillers but have led to widespread addiction and serious side effects like respiratory depression, notably seen in the U.S. opioid crisis that claimed nearly 645,000 lives from 1999 to 2021. Researchers at Johannes Gutenberg University Mainz have identified a potential alternative, aniquinazolin B, from the marine fungus Aspergillus nidulans, which binds to opioid receptors and could replace opioids with fewer undesirable effects, after rigorous testing including over 750,000 calculations per substance using the MOGON supercomputer. Researchers at Mainz University have discovered a natural compound that could potentially serve as a long-term alternative to opioids and...

HONOLULU (KHON2) -- Drug cartels from Mexico are operating in Hawaii, making and pushing deadly drugs including methamphetamines and fentanyl. New tougher penalties akin to murder charges are aiming to take them down. Authorities told KHON2 that the big cartels are ramping up business not just south of the border but right here in our island state. The top federal law enforcement official in Hawaii warns of the dangers not just to drug users, but to drug pushers once caught. Authorities have seen a big shift in recent years to Hawaii’s most dangerous drugs methamphetamine and fentanyl especially coming mostly...

DUSHANBE, Tajikistan (AP) — Russia began deporting Tajik migrants Tuesday, the first in a wave of expulsions in apparent retaliation for the jailing of a Russian pilot in the Central Asian nation, officials in Tajikistan said. The spat threatens to imperil the livelihood of thousands of Tajik laborers and stir discontent in a country struggling to protect its border with Afghanistan. The former Soviet nation's economy relies heavily on the remittances provided by the many hundreds of thousands of Tajiks working in Russia. Over the past year, Moscow has been attempting to strong-arm Tajikistan into permitting Russian border troops to...

Maine’s taxpayer-funded “harm reduction” specialists call it “boofing” or “booty dumping,” but those are just pleasant euphemisms referring to the practice of sticking heroin, fentanyl, or meth up your butt. Maine Access Points, a taxpayer-funded nonprofit based in Bangor, as well as the city of Portland’s city-run needle distribution center are both offering extensive how-to guides and — even anal injection kits — to help drug users squirt narcotics into their anuses. In Portland, the “Portland Public Health Boofing Kit” comes with a needleless syringe and an informational flyer explaining the proper technique for putting drugs up your butt.

PORTLAND Ore. (KPTV) - The U.S. Attorney’s Office-District of Oregon said four suspected drug traffickers are facing federal charges Thursday after they were caught transporting near 370 gallons of liquid heroin. Police said 44-year-old Marco Antonio Magallon, 26-year-old Luis Deleon Woodward, 25-year-old Jorge Luis Amador and 32-year-old Santos Alisael Aguilar Maya have ties to a Mexico-based transnational criminal organization. They have all been charged with conspiracy to distribute and posses with intent to distribute heroin and possess with intent to distribute heroin. Investigators watched Amador drive a rented moving truck alongside a red pickup truck west on I-84 near Bonneville....

Does texting erode language? One lazy day, my dog ate my dictionary. He really did. When I got to him, he had gone up to chewing up to “P”. But I had no choice after that but to throw away that humongous word library. One, because it (the dictionary, not my dog!) just had to be euthanized and second, well, there was an online, updatable, therefore more useful version. But come to think of it, why do we need dictionaries?

Hundreds of thousands of lives have been saved over the years when naloxone — commonly known as Narcan — is administered to someone overdosing on opioids. Drugs Illegal drugs such as cocaine, heroin, and fentanyl can be mixed with xylazine, either to enhance drug effects or increase street value by increasing their weight. sedative/tranquilizer called xylazine to heroin, fentanyl and other opioids. And that’s bad news for addicts because naloxone doesn’t reverse a xylazine overdose. National Center for Biotechnology Information “You overdose on xylazine, and you’re going to die,” said the commander of the Greater Harrison Drug & Violent Crimes...

Three years after Oregon voted to de-criminalize drug offences - residents are now begging to reverse their decision after seeing an astonishing number of deaths from opioid overdoses. In 2020 - Oregon voters approved a measure to decriminalize the possession of all drugs including heroin and cocaine. The proposal, known as Oregon Ballot Measure 110, passed with 58.8 percent support. Now residents of the liberal state are crying out to their politicians to do something about the open-air drug markets that their cities have turned into. Opioid deaths in Oregon have gone up from 280, before the de-criminalization was voted...

Oregon’s first-in-the-nation law that decriminalized the possession of small amounts of heroin, cocaine and other illicit drugs in favor of an emphasis on addiction treatment is facing strong headwinds in the progressive state after an explosion of public drug use fueled by the proliferation of fentanyl and a surge in deaths from opioids, including those of children. “The inability for people to live their day-to-day life without encountering open-air drug use is so pressing on urban folks’ minds,” said John Horvick, vice president of polling firm DHM Research. “That has very much changed people’s perspective about what they think Measure...

In the late interwar period, a few years before the ascendency of Adolf Hitler to the Chancellery, the famed German film director Fritz Lang created a classic of the silent film era. Spione (English: Spies) is a thriller of international espionage, intrigue, and manipulation by a criminal mastermind. Playing diplomats, politicians, and detectives against each other, using prostitutes, opium, and blackmail to control his adversaries, Lang’s arch villain Haghi pushes the world to the precipice of total war before he is brought down by the film’s hero. There is a man operating like this today. He has control of vast...

RFK Jr. and Joe Biden are far more disgusting than most Americans realize...This goes way beyond politics. pic.twitter.com/RNJSHdcog4— Brenden Dilley (@WarlordDilley) October 23, 2023🔥 Hell is for children 🔥w:@BrandieWithABee @JScottHolt47 @itsreallyleah @miguelifornia @WarlordDilley pic.twitter.com/LMqKBxlx5q— littlememzz (@littlememzz) October 23, 2023

“I got along with everyone,” Curtin told People in a new interview. “But I did have problems with John,” the funny woman added. “But that was because John wasn’t John. He was an addict.” Belushi’s drug problem plagued his short life and career and he died via an overdose from a speedball mix of heroin and cocaine. Original “SNL” cast member Chevy Chase revealed last year that the “Blues Brothers” star’s addiction was so severe that he stole Chase’s own stash of cocaine.

Police officers allegedly stood by and watched for 15 minutes as a man who relapsed on heroin drowned in the Tennessee River after fleeing from them, according to a newly filed lawsuit. Kimberly Williams-Clabo claims her son, Mika Wheeler Clabo, would still be alive if it weren’t for the alleged negligence of the Knoxville Police Department, which encountered him “acting erratically” on the morning of July 25, 2022. Police said that when they approached Clabo, 30, who struggled with a heroin addiction, he ran from them and jumped into the river, where he got caught on vines and drowned. In...

The Islamic Republic’s Revolutionary Guards (IRGC) have made a criminal Iran’s leading drug lord, Iran International can reveal. Information obtained by Iran International shows how Naji Sharifi-Zindashti and his cartel now dominate the narcotics trade thanks to the support of the government militia. His extraordinary rise comes despite his having killed a prison guard in Iran and fleeing abroad, only to return with impunity. Investigative reporter Mojtaba Pourmohsen has uncovered how a recent rise in the number of executions of convicts sentenced to death on drug-related charges is the result of infighting between rival drug cartels with connections within the...

(Gabriel) Rodriguez said he arrived in Denver from Washington state last Thursday, intending to move to Colorado. He said mutual friends introduced him to Richard Platt, 42, who he met for the first time on Thursday. He said Platt recommended they stay at the Maven Hotel near Coors Field, which struck a chord with Rodriguez. “I wanted to go to the All-Star show, wanted to be part of that,” said Rodriguez. He said he was armed with a 9mm pistol and also had an AR-15 rifle in his 8th floor hotel room, which he booked himself. Rodriguez said he designs...

Horrific footage shows the devastating toll the “tranq” drug epidemic has had on addicts in Philadelphia. The Kensington neighborhood — made infamous by its open-air drug market — is seen completely packed with the slumped-over and passed-out drug users in the video posted to TikTok by urbanvisuals2.0. The harrowing clip comes as the “City of Brother Love” struggles with the rising use of the drug Xylazine, or “tranq,” which is a deadly sedative used to enhance the effects of heroin, cocaine, and fentanyl. The drug is so potent the White House recently declared it an “emerging threat.”Dr. Rahul Gupta, Director...

The wife of Joaquin 'El Chapo' Guzman has been arrested at Washington DC's Dulles Airport and charged with drug trafficking, with an informant accusing her of masterminding a $3 million plan to break him out of Mexico's jails. Emma Coronel Aispuro, a 31-year-old former beauty queen with both U.S. and Mexican citizenship, was detained on Monday in the first major cartel detention of Joe Biden's administration. She will appear in court on Tuesday before Judge Harvey G. Michael, charged with participating in a conspiracy to distribute cocaine, methamphetamine, heroin and marijuana for importation into the U.S.

BOGOTA, Colombia - Mexico has passed a sweeping bill legalizing the possession of small quantities of almost all illegal drugs, including heroin and cocaine. The regime, likely to be one of the most liberal in the world, is designed to avoid clogging prisons with drug addicts, allowing police to go after big-time dealers. Under the bill, it would be legal to possess 25 milligrams of heroin, five grams of marijuana, half a gram of cocaine, as well as small amounts of LSD, hallucinogenic mushrooms, amphetamines, and a hallucinogenic cactus, peyote. All that remains is for President Fox to sign the...

A Florida man was arrested after deputies discovered a large quantity of crack cocaine and trafficking amounts of fentanyl and heroin following a vehicle pursuit. “Holley Delton Jones, 46, of Lehigh Acres, Florida, is charged with 15 felonies, most of them narcotics related. At the time of his arrest Jones was on parole for trafficking ecstasy,” said Collier County Sheriff’s Office. According to deputies, Jones was driving a bronze GMC Yukon on Wiggins Pass Road near U.S. 41 N. around midnight when deputies tried to pull him over for a traffic violation. Jones decided to accelerate and drove recklessly through...

Flagler County Sheriff Rick Staly said $5.7M worth of illegal drugs were taken off the street in Operation ‘Santa's Naughty Lil Sellers'A massive undercover operation focusing on locking up drug dealers in Flagler County, Fla., successfully came to a close after nearly a year in action. The Flagler County Sheriff's Office said $5.7 million worth of illegal drugs are off the streets thanks to the department's ‘Santa's Naughty Lil Sellers' operation. During the investigation, which began in January 2022, FCSO said its Special Investigations Unit seized enough heroin and fentanyl to "potentially kill over 2.3 million people."