Free Republic
Browse · Search
News/Activism
Topics · Post Article

Skip to comments.

An analgesic molecule discovered in its natural state in Africa
Inserm ^ | 25.09.2013 | NA

Posted on 10/07/2013 7:12:41 PM PDT by neverdem

A team of researchers led by Michel De Waard, Inserm Research Director at the Grenoble Institute of Neurosciences (Inserm, University Joseph Fourier, CNRS), has discovered that an African medicinal plant produces large quantities of molecules with analgesic properties. Even more surprising, analysis show that the molecule is identical to Tramadol, a wholly synthetic medication that is used world-wide as a painkiller. According to the research team, this is the first time ever that a synthetic medication produced by the pharmaceutical industry has been discovered in strong concentrations in a natural source. This unexpected discovery had just been published in the chemical journal’ “Angewandte Chemie.

Nauclea latifolia (also know as the pin cushion tree) is a small shrub that is widely abundant throughout Sub-Saharan Africa. In traditional medicine, in particular in Cameroon, this plant is used to treat different pathologies including epilepsy, fevers, malaria and pain.

In order to identify the presence and the type of potential active substances in this plant, Michel De Waard, Inserm Research Director, organised joint scientific research with the Grenoble Institute of Neurosciences (Inserm unit 836 UJF/CEA/CHU), the Department of Molecular Pharmacological Chemistry (UMR UJF/CNRS 5063, Pr Ahcène Boumendjel) and the University of Buea (Dr. Germain Sotoing Taiwe).

Thanks to this work, the researchers were able to isolate and determine the properties of the component in the plant that was responsible for the presumed analgesic effects, by analysing part of the root bark. And to everyone’s surprise, they found that this component was already commercially available under the name: Tramadol.

The biggest surprise in this study was the fact that this molecule was a known one. “It was identical to Tramadol, a synthetic medication developed in the seventies and often used to treat pain”, explained Michel De Waard, Inserm research director. This medication is used world-wide, because although it is a derivative of morphine, it has less side effects than morphine, in particular addiction problems.

Tramadol1 is in fact a simplified form of morphine that has conserved the elements needed to produce analgesic effects.

structure tramadol vs morphine

crédit : Structure of Tramadol versus structure of morphine

In order to confirm their results, the researchers tested different processes with the aim of proving that the substance discovered was of natural origin. Their analyses were confirmed by three independent laboratories that had received different samples at different times of the year.

“All results converge and confirm the presence of Tramadol in the root bark of Nauclea latifolia. On the other hand, no trace of this molecule was detected in the aerial part of the shrub (leaves, trunk or branches)“, explained the researcher.

Finally, in order to exclude the possibility of accidental contamination of the samples by synthetic Tramadol, the researchers took samples from inside the roots themselves and thus confirmed the presence of the molecule.

From a quantitative point of view, the concentration of Tramadol in the dried bark extracts was measured at 0.4% and 3.9%. These are extremely high levels of active substance.

In addition to the unprecedented aspect of this discovery (the first ever potentially exploitable case where a hitherto synthetically produced medication has been discovered in a natural form and in high quantities), this major result opens up prospects for local populations, giving them access to a source of cheap treatment and validating the concepts of traditional medicines (as decoctions made from barks and roots).

There are over 10 different varieties of this shrub in Africa, so we can envisage repeating the tests in order to determine which varieties contain Tramadol”, concludes Michel De Waard.

This study can also be used to provide a warning as to the risks of drug dependency linked to over-consumption of the roots of this plant. Tramadol is listed as an opiate product, just like morphine from which it is derived.

plant de citronnier

 

1 No medication is without risks and they all have potentially harmful side effects. It is impossible to predict with any certainty the effects of treatment by any medication. All medication products have both beneficial effects, but also a risk of being harmful. We can reduce this risk as far as possible by ensuring that the prescribed medication is of the correct quality, is safe, efficient, administered to the people who need it, at the right doses and at the right times. Source: WHO


TOPICS: Culture/Society; News/Current Events
KEYWORDS: analgesic; medicine; morphine; painkiller; tramadol; ultram

1 posted on 10/07/2013 7:12:42 PM PDT by neverdem
[ Post Reply | Private Reply | View Replies]

To: neverdem

Tramadol is more of a delirium-inducing drug than a painkiller.


2 posted on 10/07/2013 7:18:02 PM PDT by E. Pluribus Unum (Who knew that one day professional wrestling would be less fake than professional journalism?)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

I guess that will be ANOTHER banned plant!


3 posted on 10/07/2013 7:21:27 PM PDT by noprogs (Borders, Language, Culture)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

Wait I thought natural medicine was fake.


4 posted on 10/07/2013 7:25:43 PM PDT by driftdiver (I could eat it raw, but why do that when I have a fire.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: E. Pluribus Unum
Well, not to be a real smart-ass, but for several types of minor pain that I have treated with Tramadol, it is very effective for “killing” pain. For example, I used it on minor arthritis, temporarily, with great success. There may be a medical definition for delirium that I'm not aware of; never got delirious.
5 posted on 10/07/2013 7:35:03 PM PDT by Ace's Dad (Proud grandpa of a newly born "Brit Chick" named Poppy Loucks!)
[ Post Reply | Private Reply | To 2 | View Replies]

To: E. Pluribus Unum
Tramadol is more of a delirium-inducing drug than a painkiller.

I thought the generic name for Tramadol was Placebo.
6 posted on 10/07/2013 7:35:19 PM PDT by PA Engineer (Liberate America from the Occupation Media. No Blood For Ego!)
[ Post Reply | Private Reply | To 2 | View Replies]

To: PA Engineer

I wish I’d thought of that.


7 posted on 10/07/2013 7:37:05 PM PDT by E. Pluribus Unum (Who knew that one day professional wrestling would be less fake than professional journalism?)
[ Post Reply | Private Reply | To 6 | View Replies]

To: E. Pluribus Unum

So, you are saying it is the drug of choice for the Obamanistas?


8 posted on 10/07/2013 7:37:19 PM PDT by LachlanMinnesota
[ Post Reply | Private Reply | To 2 | View Replies]

To: E. Pluribus Unum
I was on Tramadol for four years until it stopped working. No delirium at all for me. If fact I first got it from my Flight Surgeon.

Garde la Foi, mes amis! Nous nous sommes les sauveurs de la République! Maintenant et Toujours!
(Keep the Faith, my friends! We are the saviors of the Republic! Now and Forever!)

LonePalm, le Républicain du verre cassé (The Broken Glass Republican)

9 posted on 10/07/2013 7:38:20 PM PDT by LonePalm (Commander and Chef)
[ Post Reply | Private Reply | To 2 | View Replies]

To: neverdem
Tramadol has a lot of uses but not all FDA approved uses. Have you read about its anti depressive properties? http://www.ncbi.nlm.nih.gov/pubmed/15358985 http://www.ncbi.nlm.nih.gov/pubmed/9749830 and just a sitehttp://www.beatingthebeast.com/forum/index.php?showtopic=24115
10 posted on 10/07/2013 7:47:55 PM PDT by Bronzy
[ Post Reply | Private Reply | To 1 | View Replies]

To: E. Pluribus Unum

Tramadol = Synthetic morphine. It is not an analgesic. It says that it is classified as an opiate in the article. Its a narcotic. Its not a shrub. It was concocted in a laboratory.

Physically addicted to it for over 6 years. POLY-Pharmacy does not work.

BAD BAD MEDICINE!!


11 posted on 10/07/2013 7:49:13 PM PDT by Delta 21 (Oh Crap !! Did I say that out loud ??!??)
[ Post Reply | Private Reply | To 2 | View Replies]

To: neverdem

So will the owners of the Tramadol patent sue the plants for patent infringement?


12 posted on 10/07/2013 7:51:39 PM PDT by 17th Miss Regt
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

The worst side effect of Tramodol is it don’t work (at stopping pain) for which it is mostly proscribed.


13 posted on 10/07/2013 7:55:40 PM PDT by corbe (mystified)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

So what are Morphine, aspirin and digitalis, chopped liver?


14 posted on 10/07/2013 8:13:28 PM PDT by Lx (Do you like it? Do you like it, Scott? I call it, "Mr. & Mrs. Tenorman Chili.")
[ Post Reply | Private Reply | To 1 | View Replies]

To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
Disarming HIV with a 'Pop'

Government Overreach Threatens Lives - Will the FDA shut down vital stem-cell treatments?

When Smartphones Do a Doctor’s Job: A simple, cheap way to measure eyesight may face resistance.

Tiny Glass Chip Accelerators Pack the Punch of Huge Mile-Long Instruments

FReepmail me if you want on or off my health and science ping list.

15 posted on 10/07/2013 8:19:57 PM PDT by neverdem (Register pressure cookers! /s)
[ Post Reply | Private Reply | To 1 | View Replies]

To: noprogs

BINGO!


16 posted on 10/07/2013 8:31:21 PM PDT by ASouthernGrl (BHO sucks - literally or metaphorically, you decide.)
[ Post Reply | Private Reply | To 3 | View Replies]

To: corbe
The worst side effect of Tramodol is it don’t work (at stopping pain) for which it is mostly proscribed.

I have yet to be prescribed a narcotic that actually stops pain. In fact, the side effects are so nasty that the last time I was offered narcotics, I turned them down. For the procedure I had, sedation worked very well.

17 posted on 10/07/2013 8:32:19 PM PDT by exDemMom (Now that I've finally accepted that I'm living a bad hair life, I'm more at peace with the world.)
[ Post Reply | Private Reply | To 13 | View Replies]

To: 17th Miss Regt
So will the owners of the Tramadol patent sue the plants for patent infringement?

Not necessary, that's what Roundup was invented for.

18 posted on 10/07/2013 8:48:55 PM PDT by Balding_Eagle (Damn ObamaCare, full speed ahead!)
[ Post Reply | Private Reply | To 12 | View Replies]

To: E. Pluribus Unum
Tramadol is more of a delirium-inducing drug than a painkiller.

Why I take it all the time and I am not delirious...so drop the mustard silly toad. And why is my computer screen turning into dancing moose?

19 posted on 10/07/2013 8:56:01 PM PDT by AndyTheBear
[ Post Reply | Private Reply | To 2 | View Replies]

To: noprogs

So here come the drug warriors. I don’t care. For some people it would be good to collect recipes for possible tough times. At the reported concentrations it would be super easy to extract effective quantities of the good stuff.


20 posted on 10/07/2013 9:01:35 PM PDT by Clinging Bitterly (R.I P. my old FRiend and neighbor Blackie Owens. Be ever vigilant!)
[ Post Reply | Private Reply | To 3 | View Replies]

To: neverdem

Reading all the commentaries was more interesting and entertaining than the actual article. What goes for this plant is similar in nature as for the willow tree bark extract salicin, the forerunner of today’s Aspirin.


21 posted on 10/08/2013 12:46:19 AM PDT by saintgermaine
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem
I've had Tramadol, it doesn't work for me as a pain killer.
But I followed the directions & dosages. ;-)
22 posted on 10/08/2013 7:19:44 AM PDT by Condor51 (Si vis pacem, para bellum.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

Have you seen this?

http://www.futurity.org/can-peanut-butter-smell-test-confirm-alzheimers/

A dollop of peanut butter and a ruler might be a way to confirm a diagnosis of early-stage Alzheimer’s disease.


23 posted on 10/09/2013 5:24:41 AM PDT by GOPJ (Brieitbart sent me... Freeper newfreep)
[ Post Reply | Private Reply | To 1 | View Replies]

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
News/Activism
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson