I do know that consuming high-fructose corn sweetener cleans me out like Tid-Y-Bowl.
No it doesn’t. There’s study after study that says it metabolizes just like sugar.
White Castles do it for me.
But, but, but the corn lobby! And their government subsidized studies! And their government subsidized farming! Who are you going to believe? Them or your lying eyes?
Are you sure that it's HFCS causing those problems, and not another sweetener?
Sorbitol and xylitol are commonly used as sweeteners, and do have the exact effect that you describe. They are metabolized very slowly by your body, but the bacteria in your gut like them just fine. When the bacteria eat those sweeteners, they produce a lot of gas. Plus, those sweeteners cause an influx of fluid into your gut, which has laxative properties. It does not take a large dose to get those effects; chewing a few sticks of sugar-free gum will do the trick.
Given that sucrose is exactly 50% fructose/50% glucose, and HFCS has variable portions of both sugars (the most common HFCS has 55% fructose/45% sucrose), there is no biochemical basis for HFCS to have that effect on you if sugar and honey do not. Honey is almost identical to HFCS, except that it also has the flavor components added thanks to its being regurgitated by bees. Agave syrup, a popular "natural" sucrose substitute, is almost all fructose.