I am not a doctor. What does
"when expressed in cancer cells ..."
mean?
Did they mean to say "when suppressed in cancer cells ..." and if so, how do you suppress a gene?
If not, how do you express a gene?
Anyway, this sounds pretty exciting!
Maybe it means cancer cells intentionally introduced into the environment, i.e., not native, having been indigenously matured.
I am not a doctor. What does
“when expressed in cancer cells ...”
mean?
________________________________________
Basically means it is the gene that’s responsible for the creation of a particular protein
‘Expressing’ a gene means to ‘turn it on’. If this is a gene that is common in cancer cells and not found in normal cells, they have to discover a chemical ‘switch’ to turn it on, essentially killing the cells and the cancer..........
Expression of a gene means the gene is activated to begin transcription of RNA, which is then (typically) translated into a protein. To express a gene in a cancer cell, there are two general situations. First, the cancer cell already contains the gene, but it is not normally expressed. To make it express, you can basically suppress the things that are inhibiting its expression (or mRNA translation), or add things that encourage its expression/translation. The second situation is when the gene you wish to introduce is not found in the cell, but you wish to express it. To do this, you introduce a DNA/mRNA construct that will express the gene by targeting it to those specific cells. To get an idea of how this is done search on “cell transfection” for how to get into the cell in general, and “gene therapy” or “tissue/cell specific targeting” to see that there are many approaches to targeting specific cells or tissue.