No need for a bigger weapon. Just practice with your .380 and make your shots count.
I was thinking get off a shot(s) to the chest or the face but that guy in FL after the security guard started shooting at the shooter, he still managed to get off another 6 or so shots at him and the security guard had clipped him in the leg or shoulder, not sure which.
Precisely. I carried a .22 semi-auto for years. Practiced making ‘paper plate’ grouped shots under varying motions and speeds. Two locations on the human body using a .22 will drop someone: head shot, or well placed shot(s) to the bladder region where lots of nerves and major blood vessels run. The bladder shot is a very painful injury, while the head shot will likely disconnect brain from body muscles. I only changed calibers because I purchased a nice CZ82 in 9x18.