Free Republic
Browse · Search
News/Activism
Topics · Post Article

Skip to comments.

New Arena for Testing of Drugs: Real World (The Evidence Gap)
NY Times ^ | November 25, 2008 | GINA KOLATA

Posted on 11/25/2008 9:04:03 PM PST by neverdem

Sylvia Syvenky went for a routine dental appointment in early October, expecting to have two caps on her teeth replaced. But something went terribly wrong.

“I felt like I was choking,” Mrs. Syvenky said. “I couldn’t take a breath. All sorts of gurgly sounds were coming out of me.”

She was rushed by ambulance to University Hospital near her home in Edmonton, Alberta, where doctors placed a mask on her face and forced air into her lungs. They told her she had heart failure. After her condition improved, they asked her to sign up for a study of a new drug to help with breathing.

Mrs. Syvenky is like many with heart failure who arrive at hospitals, unable to breathe. Yet she is the last person who would normally be asked to join a research study. At age 70, she was much older than typical study participants and her symptoms were too complex.

But now there is a growing movement to gather a new kind of evidence, the kind that will fill some of the biggest gaps in medical science: What treatment is best for typical patients with complex symptoms, like Mrs. Syvenky? Many are elderly with several chronic conditions and taking several unrelated medications. And what are the long-term effects of a treatment — death rates, side effects, progression of the disease?

A group of advocates, including medical researchers, medical societies and insurers, is lobbying Congress to pay for an Institute for Comparative Effectiveness Research that would assess treatments and identify gaps in evidence. When there are gaps, the institute would initiate what are being called “real world,” or “pragmatic,” clinical research trials to gather the evidence.

Some leading...

--snip--

“There has been a 90-degree turn” in thinking, said Dr. Eugene Braunwald, an eminent cardiologist at Harvard Medical School...

(Excerpt) Read more at nytimes.com ...


TOPICS: Business/Economy; Culture/Society; Government; Testing
KEYWORDS: drugs; drugtesting; health; medicine
When Braunwald speaks, docs listen.
1 posted on 11/25/2008 9:04:03 PM PST by neverdem
[ Post Reply | Private Reply | View Replies]

To: neverdem
A group of advocates, including medical researchers, medical societies and insurers, is lobbying Congress to pay for an Institute for Comparative Effectiveness Research

Harvard is sitting on $37 billion in endowments. How about private educational institutions pick up the tab for a change instead of the taxpayer?

2 posted on 11/25/2008 9:26:56 PM PST by LibFreeOrDie (Obama promised a gold mine, but he will give us the shaft.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: LibFreeOrDie
private? PRIVATE? Yeah....wouldn't THAT be nice....for the auto industries, for the banking industry, etc.....
3 posted on 11/25/2008 9:29:11 PM PST by goodnesswins (CONSERVATIVES....saving America's A** whether you like it or not!)
[ Post Reply | Private Reply | To 2 | View Replies]

To: neverdem
"Many are elderly with several chronic conditions and taking several unrelated medications. And what are the long-term effects of a treatment — death rates, side effects, progression of the disease? "

At this point, since we are one with big world government (see China), does anyone really care about the elderly any longer? I thought the marixist thought was to euthanize all the "uselss" people.

4 posted on 11/25/2008 9:52:55 PM PST by Earthdweller (Socialism makes you feel better about oppressing people.....)
[ Post Reply | Private Reply | To 1 | View Replies]

To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
Potassium loss from blood pressure drugs increases diabetes risk by 50%

University cancels cystic fibrosis fundraiser because disease only affects white men That's wrong. The article is very short.

FDA Finds Traces of Melamine in US infant Formula

Did NBC Risk Employees Lives in a Green Agenda Stunt? You'll laugh at these fools!

FReepmail me if you want on or off my health and science ping list.

5 posted on 11/25/2008 10:03:18 PM PST by neverdem (Xin loi min oi)
[ Post Reply | Private Reply | To 1 | View Replies]

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
News/Activism
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson