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Sleep Drugs Found Only Mildly Effective, but Wildly Popular
NY Times ^ | October 23, 2007 | STEPHANIE SAUL

Posted on 10/26/2007 3:08:20 PM PDT by neverdem

Your dreams miss you.

Or so says a television commercial for Rozerem, the sleeping pill. In the commercial, the dreams involve Abraham Lincoln, a beaver and a deep-sea diver.

Not the stuff most dreams are made of. But if the unusual pitch makes you want to try Rozerem, consider that it costs about $3.50 a pill; gets you to sleep 7 to 16 minutes faster than a placebo, or fake pill; and increases total sleep time 11 to 19 minutes, according to an analysis last year.

If those numbers send you out to buy another brand, consider this, as well: Sleeping pills in general do not greatly improve sleep for the average person.

American consumers spend $4.5 billion a year for sleep medications. Their popularity may lie in a mystery that confounds researchers. Many people who take them think they work far better than laboratory measurements show they do.

An analysis of sleeping pill studies found that when people were monitored in the lab, newer drugs like Ambien, Lunesta and Sonata worked better than fake pills. But the results were not overwhelming, said the analysis, which was published this year and financed by the National Institutes of Health.

The analysis said that viewed as a group, the pills reduced the average time to go to sleep 12.8 minutes compared with fake pills, and increased total sleep time 11.4 minutes. The drug makers point to individual studies with better results.

Subjects who took older drugs like Halcion and Restoril fell asleep 10 minutes faster and slept 32 minutes longer than the placebo group. Paradoxically, when subjects were asked how well they slept, they reported better results, 52 extra minutes of sleep with the older drugs and 32 minutes with the newer drugs.

“People seem to be getting a lot of relief...?”

(Excerpt) Read more at nytimes.com ...


TOPICS: Culture/Society; Government; News/Current Events
KEYWORDS: drugs; health; medicine; sleep
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1 posted on 10/26/2007 3:08:22 PM PDT by neverdem
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To: neverdem

2400 IUs of calcium several hours before retiring helps me. Have some camomile tea but haven’t tried it yet. Tylenol PM is said not to be addictive, but it leaves me groggy in the AM. For younger women, 1200 IUs of calcium may be adequate.

With all that is going on in this country these days, is it any wonder Americans are having trouble sleeping?


2 posted on 10/26/2007 3:13:47 PM PDT by Paperdoll ( Duncan Hunter '08)
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To: neverdem

I sometimes lay awake at night and can not sleep.
If I take just 1/2 of a walmart generic version
of over-the-counter “unisom” I will sleep like
a baby with no ill effects in the morning.

I only do it every now and then
when I just really need to get some sleep.

Because I have always had a fear of all drugs
and becoming dependent on them.


3 posted on 10/26/2007 3:15:26 PM PDT by Repeal The 17th
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To: neverdem

melatonin is about the best sleep inducer I’ve ever had.


4 posted on 10/26/2007 3:17:44 PM PDT by GregoryFul (is a bear a bomb in a bull?)
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To: neverdem

Heck, I get better results with a shot of Vodka. :-p


5 posted on 10/26/2007 3:18:05 PM PDT by KosmicKitty (WARNING: Hormonally crazed woman ahead!!)
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To: neverdem
I often use melatonin. It’s dirt-cheap, & effective for anyone who has trouble sleeping due to a deficiency of natural melatonin. If you’re over 40, and don’t have a more likely reason for not sleeping well, it’s worth considering. It’s sold OTC. Unlike other sleep-inducing drugs, you get a natural sleep & don’t feel groggy in the morning.
6 posted on 10/26/2007 3:18:13 PM PDT by USFRIENDINVICTORIA
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To: neverdem

A nice glass of red wine works wonders.


7 posted on 10/26/2007 3:18:46 PM PDT by Popman
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To: neverdem

“But if the unusual pitch makes you want to try Rozerem...”

I have no need of the product...
but I LOVE the Rozerem commercials.

The reparte between the Abraham Lincoln character and the beaver
(woodchuck?) is sometimes just priceless.


8 posted on 10/26/2007 3:19:11 PM PDT by VOA
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To: GregoryFul

Beat me too it.


9 posted on 10/26/2007 3:19:18 PM PDT by USFRIENDINVICTORIA
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To: Paperdoll

FYI: Be careful with camomile tea if you’re allergic to ragweed.


10 posted on 10/26/2007 3:19:31 PM PDT by ~Kim4VRWC's~ (Please pray for our troops.... http://anyservicemember.navy.mil/)
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To: neverdem
“newer drugs like Ambien”
I’ve got horror stories about this cr@ppy pill. I almost burned down my house whilst sleep-walking. Hadn’t had sleepwalking problems since I was a kid. I had to remodel my house cuz of smoke damage.
11 posted on 10/26/2007 3:19:34 PM PDT by Dr. Bogus Pachysandra ("Don't touch that thing")
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To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
Minerals from French Clay Cure Deadly Drug-Resistant Bacteria

French Dirt May Kill MRSA

Defect Suspected in Fabric of Space-Time

FReepmail me if you want on or off my health and science ping list.

12 posted on 10/26/2007 3:20:58 PM PDT by neverdem (Call talk radio. We need a Constitutional Amendment for Congressional term limits. Let's Roll!)
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To: Paperdoll
Tylenol PM is said not to be addictive, but it leaves me groggy in the AM.

Long-term use of Tylenol PM interferes with your memory. It prevents your brain from getting to the sleep stage where "memory compilation" happens, and that's why you feel scattered after being on it after a long time.

I take Trazadone when I get desperate (sleep-disturbed perimenopause), but the dreams on that stuff tend to be just nuts.

13 posted on 10/26/2007 3:21:16 PM PDT by Kieri (Midwest Snark Claw & Feather Club Founder)
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To: Kieri

I just put Dr Laura on the radio.....works in 3 or 4 minutes and it’s free.


14 posted on 10/26/2007 3:25:35 PM PDT by Vn_survivor_67-68
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To: ~Kim4VRWC's~

>Be careful with camomile tea if you’re allergic to ragweed.<

Thank you, Kim. I don’t think I am, but I’ll be careful.


15 posted on 10/26/2007 3:27:48 PM PDT by Paperdoll ( Duncan Hunter '08)
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To: GregoryFul

You can build up an immunity to melatonin. At least I did.


16 posted on 10/26/2007 3:29:09 PM PDT by Paperdoll ( Duncan Hunter '08)
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To: Paperdoll

You’re welcome! I am allergic to ragweed, I was lucky it wasn’t ragweed season when my “mother-n-law” unknowingly (LOL) gave it to me. :) I suffered minimal reactions.


17 posted on 10/26/2007 3:30:41 PM PDT by ~Kim4VRWC's~ (Please pray for our troops.... http://anyservicemember.navy.mil/)
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To: neverdem
newer drugs like Ambien, ...worked better than fake pills

They sure about that? Ambien inhibits short term memory from becoming long term. Maybe they just don't remember getting to sleep faster.

18 posted on 10/26/2007 3:30:56 PM PDT by Domandred (Eagles soar, but unfortunately weasels never get sucked into jet engines)
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To: GregoryFul

melatonin works for me


19 posted on 10/26/2007 3:31:26 PM PDT by mylife
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To: neverdem

20 posted on 10/26/2007 3:32:46 PM PDT by UnklGene
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To: Dr. Bogus Pachysandra

Holy Cow! what happened?


21 posted on 10/26/2007 3:33:02 PM PDT by mylife
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To: Repeal The 17th
Your haiku is really off.
You need to get more sleep.
If walmart pills don't do it
Try counting wooly sheep

Thank you. Please, no. Thank you all.

22 posted on 10/26/2007 3:33:55 PM PDT by robertpaulsen
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To: neverdem
Number one sleep aid:

A video (or audio) of an Al Gore speech.

23 posted on 10/26/2007 3:34:04 PM PDT by capt. norm (Be thankful we're not getting all the government we're paying for.)
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To: Vn_survivor_67-68

LOL! If not, try Michael Medved! :)


24 posted on 10/26/2007 3:35:01 PM PDT by Paperdoll ( Duncan Hunter '08)
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To: neverdem
Paradoxically, when subjects were asked how well they slept, they reported better results,

Maybe people sleep better at home than when monitored in a lab.

25 posted on 10/26/2007 3:35:19 PM PDT by Right Wing Assault ("..this administration is planning a 'Right Wing Assault' on values and ideals.." - John Kerry)
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To: Paperdoll
2400 IUs of calcium several hours before retiring helps me.

I never heard about elemental calcium in International Units. Usually you see a calcium salt with the weight expressed in milligrams.

Calcium exists in nature only in combination with other substances called compounds. Several different calcium compounds are used in supplements, including calcium carbonate, calcium phosphate and calcium citrate. These compounds contain different amounts of elemental calcium, which is the actual amount of calcium in the supplement. It is important to read the label carefully to determine how much elemental calcium is in the supplement and how many doses or pills to take.

26 posted on 10/26/2007 3:36:57 PM PDT by neverdem (Call talk radio. We need a Constitutional Amendment for Congressional term limits. Let's Roll!)
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To: neverdem
I just discovered the best sleeping potion ever. A Benedryl and 2.5 Valium.
27 posted on 10/26/2007 3:39:05 PM PDT by Ditter
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To: neverdem
I’ve had great results with Lunesta for insomnia.

Ambien was horrible. Knocks me out at first, but then I turned into a bizarre zombie creature half awake/half asleep.

Sonata was like a 7 hour coma and didn’t feel rested afterward. Like your psyche never resets.

28 posted on 10/26/2007 3:39:37 PM PDT by zencat (The universe is not what it appears, nor is it something else.)
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To: neverdem

You are right! I just looked, and the vitamin D part is in IUs. The calcium is in miligrams. Thank you.


29 posted on 10/26/2007 3:41:19 PM PDT by Paperdoll ( Duncan Hunter '08)
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To: neverdem

Sominex knocks me stone cold for 12 hours.


30 posted on 10/26/2007 3:46:10 PM PDT by Dr.Deth
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To: neverdem
You can build up an immunity to melatonin. At least I did.

My dad's had a prescription for Sonata for years. He's
gotten so tolerant of it, he was taking 2-3 a night.

That alarmed me - he's very unsteady on his feet in any
case, and add that he drinks coffee right up to bedtime -
He's up peeing all night. Stubborn ol' cuss :)

Other cancer and pain meds limit what he can take for sleep.

I had him start taking a Melatonin with his first Sonata
and he said after a week it didn't work - then after two
weeks he said he's sleeping better than before.

I figure he had a week of rebound, but I worry a lot less
than I did about him falling and breaking his hip while
over-medicating himself and being so groggy.

So, I'm hoping he doesn't get a high tolerance to the
Melatonin, too. It's helping a lot right now.
31 posted on 10/26/2007 3:48:10 PM PDT by Dominnae ("An appeaser is one who feeds a crocodile hoping it will eat him last." -- Winston Churchill)
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To: KosmicKitty

beer.
specifically: Fat Tire.
If 1 doesn’t work, drink another.


32 posted on 10/26/2007 3:52:45 PM PDT by mad puppy (I'd rather live a day on my feet than a year on my knees)
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To: Dr. Bogus Pachysandra
Ambien is just bad.

Big side effects, and not enjoyable, either. I don't understand why people take this crap recreationally.

33 posted on 10/26/2007 3:54:05 PM PDT by SIDENET (Hubba Hubba...)
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To: Paperdoll
You can build up an immunity to melatonin.

I think I did too, sort of. After taking melatonin for years I ran out and didn't replace it. It is true my sleep was iffy for the first week or so, but then started sleeping just fine again as I had been while on melatonin. So there was a minor dependency, but maybe a level of tolerance also, and I seem no worse off now not taking it.

34 posted on 10/26/2007 4:02:51 PM PDT by steve86 (Acerbic by nature, not nurture ™)
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To: steve86

Wanted to say also that diphenhydramine (Benadryl) works like a charm for me, but much TOO well. One tablet and I won’t wake up for minor irritations like having the covers off me and freezing to death, two tablets I wouldn’t wake up for emergencies including the smoke alarm, and three I might not wake up at all.


35 posted on 10/26/2007 4:06:41 PM PDT by steve86 (Acerbic by nature, not nurture ™)
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To: UnklGene; cardinal4

According to the commercials, one of the side-effects of this sleeping medicine is “it makes you drowsy!” Isn’t that the whole point?


36 posted on 10/26/2007 4:20:29 PM PDT by Ax (Sucks to be a Dolphin fan.)
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To: steve86
Wanted to say also that diphenhydramine (Benadryl) works like a charm for me, but much TOO well.

If you have 50 mg tablets, you can break them in half, roughly, even though they are not scored. Using a sharp blade also works.

37 posted on 10/26/2007 4:28:59 PM PDT by neverdem (Call talk radio. We need a Constitutional Amendment for Congressional term limits. Let's Roll!)
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To: zencat

Lunesta was OK but in the beginning the dreams were awful! And I swear I could taste metal bananas. lol I can’t afford it now so am back on Ambien when I need it. I prefer not to take a sleep-aid but insomnia is brutal.


38 posted on 10/26/2007 4:29:55 PM PDT by ozaukeemom (Nuke the ACLU and their snivel rights)
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To: neverdem
Not the stuff most dreams are made of. But if the unusual pitch makes you want to try Rozerem, consider that it costs about $3.50 a pill; gets you to sleep 7 to 16 minutes faster than a placebo, or fake pill; and increases total sleep time 11 to 19 minutes, according to an analysis last year.

I find that melatonin works better than that, at a small fraction of the price. Some people do react to it, though, so exercise caution when starting on it.

39 posted on 10/26/2007 4:38:19 PM PDT by BlazingArizona
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To: neverdem; steve86

They stock pill cutters in all pharmacies, and they are inexpensive. Work better than a razor blade.


40 posted on 10/26/2007 4:38:28 PM PDT by Paperdoll ( Duncan Hunter '08)
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To: Paperdoll

The one I have has a compartment to keep the pills too


41 posted on 10/26/2007 4:41:59 PM PDT by ozaukeemom (Nuke the ACLU and their snivel rights)
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To: neverdem

I never understood sleep dope.

When I’m high....I prefer to stay awake and enjoy it.


42 posted on 10/26/2007 4:44:02 PM PDT by wardaddy (Behind the lines in Vichy Nashville)
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To: mylife
“what happened?”
Well, I was sleep walkin’ and decided I wanted somethin’ to eat. Fired up a frypan, put in some chicken, and sat down in front of the tv to watch something. The tv wasn’t on. I was awakened when I started coughing my guts out. The smoke and coughing woke me up, and I realized the smoke was comin’ from the stove. I turned it off, and opened all the doors and windows. But the damage was done.
There was a murder case last year about a girl who shot and killed her grandparents. She had taken Ambien. She was found guilty, but, due to my own experience with Ambien, I believe she was innocent.
43 posted on 10/26/2007 4:45:34 PM PDT by Dr. Bogus Pachysandra ("Don't touch that thing")
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To: neverdem

OMG!

I’ve taken Ambien and Sonata for short periods of time before, and for me they worked WONDERS! I can see why people get hooked on them. You just take a pill, and then you just go to sleep! No feeling drugged, no struggle, no tossing and turning, just sweet, sweet slumber. It’s awesome. Because I hate not being able to fall asleep. If any terrorists wanted to torture me or get me to reveal state secrets, all they’d have to do would be to keep me awake a night or two.

Consequently, my doctor won’t prescribe sleeping pills to me except only a few days’ worth at a time, and only for special occasions like a long trip. I think the grand total he’s given to me over the past 15 years is...15 sleeping pills. But they’re awesome.


44 posted on 10/26/2007 4:48:03 PM PDT by wimpycat (Hyperbole is the opiate of the activist wacko.)
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To: stylecouncilor

ping


45 posted on 10/26/2007 4:50:17 PM PDT by windcliff
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To: neverdem

If they really want to sell, they need a better disclaimer. For example, “If you experience an incredible enhancement in your sexual pleasure this may be a serious side effect. Please consult your physician.” That should work, it did for Levietra.


46 posted on 10/26/2007 4:51:38 PM PDT by joebuck
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To: steve86
I took Benadryl to help me sleep and it gave me restless leg syndrome.
47 posted on 10/26/2007 5:02:02 PM PDT by muggs
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To: mylife

melatonin only lasts 4 hrs and I wake up again


48 posted on 10/26/2007 5:08:40 PM PDT by LynnHam
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To: neverdem

I’ve used melatonin when I’m jet lagged from an Asia or Europe trip. I adjust going over in a day or two, but coming back wipes me out for a week(for Asia, Europe is 2 days). Using melatonin for two or three nights cut that Asian lag down by two days and for Europe, it’s just one day.

What I’ve found it does for me is eliminate waking up every hour. I still wake up every 3 hours for a few minutes, but it eliminates the in-betweens.

I probably only use it 6 times a year so I certainly haven’t built a tolerance to it.


49 posted on 10/26/2007 5:12:06 PM PDT by Malsua
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To: Paperdoll

I was on Ambein for years, worked great at first, but built up a tolerance over time (became expensive). Begin to have some memory problems and got a little scared. Finally weaned myself off and switched to OTC Melatonin worked great. You can build up a tolerance over time, but still cheaper than prescription aids. I started on 3mg per night two years ago and have gone up to 6 mg at present. Tolerance seems to be slow and at a rate that I can accept.

Without Melatonin, it can take me hours to get to sleep. With Melatonin, about 30 min.


50 posted on 10/26/2007 5:16:49 PM PDT by doc1019 (Fred Thompson '08)
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