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Multipotent stem cells discovered in hair follicle (End to baldness?)
pharmaceutical-business-review ^ | 6 Oct 2005,

Posted on 10/06/2005 8:49:11 AM PDT by jb6

Researchers have discovered that certain cells inside the hair follicle are true multipotent stem cells, capable of developing into the many different cell types needed for hair growth and follicle replacement. 6 Oct 2005, 09:42 GMT - Using an animal model scientists at the Ecole Polytechnique Federale de Lausanne (EPFL) have demonstrated that these holoclones can be used for long-term follicle renewal.

The researchers isolated stem cells from rat whisker follicles, labeled them and grew them in culture for 140 generations. They then implanted progeny cells into the skin of newborn mice whose hair follicles were just being formed. This skin was then grafted onto athymic (nude) mice. Some cells were incorporated into developing follicles, but other follicles were completely made up of labeled cells.

Each progeny cell contributed to the formation of eight different types of cell in the follicle, including those of the outer root sheath, inner root sheath, the hair shaft, the sebaceous gland and the epidermis.

After 125 days, a biopsy was taken from the graft, and labeled stem cells were isolated, subcloned, cultivated and then once again transplanted. The rat whisker stem cells participated again in forming all the cell types needed to form the hair follicle and sebaceous glands, resulting in hair bulbs that underwent repeated normal phases of growth, rest and regeneration.

The fact that the transplanted cells participate in the hair cycle over long periods of time shows that they are true multipotent stem cells and not progeniture cells, leading the researchers to suggest that it could be possible to generate the complete human hair bulb capable of lasting for years. This finding has important implications for regenerative medicine. For example, the method could one day be used to regenerate hair on patients with severe burns.


TOPICS: Miscellaneous
KEYWORDS: cells; hair; regeneration; stem; stemcells

1 posted on 10/06/2005 8:49:15 AM PDT by jb6
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To: jb6

But, But Stem Cells Bad! Waaaahh!


2 posted on 10/06/2005 8:51:53 AM PDT by master thesis (E=MC2 when apes evolve to people)
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To: All

BUMP


3 posted on 10/06/2005 8:53:39 AM PDT by longtermmemmory (VOTE!)
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To: master thesis

Naw DU troll they aren't bad. The idea of disposable humans is the bad part. Mmmmkay?


4 posted on 10/06/2005 8:54:43 AM PDT by kinghorse
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To: jb6
For example, the method could one day be used to regenerate hair on patients with severe burns.

I'm sure if this technology comes to pass that regenerating hair on patients with severe burns will make up a fraction of a percent of it's usage. What's the stock ticker? :)

5 posted on 10/06/2005 8:54:57 AM PDT by not_apathetic_anymore
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To: master thesis
But, But Stem Cells Bad! Waaaahh!

Stem cells are wonderful. A market in human tissue from unwilling donors is the bad part.

6 posted on 10/06/2005 8:59:48 AM PDT by The_Victor (If all I want is a warm feeling, I should just wet my pants.)
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To: jb6

Note to self: Sell Couvre stock!


7 posted on 10/06/2005 9:05:52 AM PDT by Wally_Kalbacken
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To: jb6
researchers isolated stem cells from rat whisker follicles

I wonder what Al Gore would look like with rat whiskers growing out of his scalp?

8 posted on 10/06/2005 9:08:53 AM PDT by Ben Mugged
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To: jb6

And remember, I'm not just the president of the Follicle Club for Men, I'm also a member!


9 posted on 10/06/2005 9:13:59 AM PDT by George Smiley (This tagline deliberately targeted journalists.)
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To: George Smiley

This treatment has been tried before, and failed . Henry Waxman was a participant in the field trials, and the stem cells implanted in his head resultd in long nasal hairs growing.


10 posted on 10/06/2005 9:19:08 AM PDT by ken5050 (Ann Coulter needs to have children ASAP to pass on her gene pool....any volunteers?)
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To: master thesis

DUh


11 posted on 10/06/2005 9:20:54 AM PDT by Conspiracy Guy (Ponce de Leon is coming here to look for the fountain of dumb. The DNC is his first stop.)
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To: master thesis
Sign up today to make asinine comment?
12 posted on 10/06/2005 9:45:02 AM PDT by tallhappy (Juntos Podemos!)
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To: tallhappy
"Sign up today to make asinine comment?"

Morons like to do just that, then they sit back and laugh without posting a response.

13 posted on 10/06/2005 10:05:24 AM PDT by #1CTYankee (I thought about that and DELIBERATELY didn't go there. ((Or maybe I did?))
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To: master thesis; FormerLib; MarMema; GarySpFc

Details are what gets the troll. No one said stem cells are bad, stem cells harvested from aborted infants or embryos grown for harvesting are bad....and this discovery, like almost every in stem cells, is from adults....so much for another defense for keeping abortion legal.


14 posted on 10/06/2005 10:15:29 AM PDT by jb6 (The Atheist/Pagan mind, a quandary wrapped in egoism and served with a side order of self importance)
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To: Ben Mugged

What??? They aren't already?


15 posted on 10/06/2005 10:16:57 AM PDT by jb6 (The Atheist/Pagan mind, a quandary wrapped in egoism and served with a side order of self importance)
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To: PatrickHenry; b_sharp; neutrality; anguish; SeaLion; Fractal Trader; grjr21; bitt; KevinDavis; ...
FutureTechPing!
An emergent technologies list covering biomedical
research, fusion power, nanotech, AI robotics, and
other related fields. FReepmail to join or drop.

16 posted on 10/08/2005 12:16:21 PM PDT by AntiGuv (™)
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To: AntiGuv

17 posted on 10/08/2005 12:41:07 PM PDT by Solamente
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