Posted on 04/14/2024 8:37:14 PM PDT by ConservativeMind
Regular aerobic exercise later in life prevents genomic instability characterized by DNA damage and telomere dysfunction, according to a study.
"These new findings will greatly impact our understanding of the mechanisms of how aerobic exercise improves vascular health at the level of genomic stability," says Jisok Lim, Ph.D.
Late-life exercise used to be thought of as ineffective. However, existing studies indicate aerobic exercise later in life lowers the risk of cardiovascular disease-related mortality. Yet, specific factors contributing to this effect have not been completely understood.
Researchers examined whether regular exercise with aging may prevent DNA damage and telomere dysfunction. Telomeres are protective caps at the end of chromosomes. In this study, exercise was shown to be especially helpful in cells that come in direct contact with blood flow (endothelial cells). The benefits of aerobic exercise are particularly noticeable in the aortic regions less prone to atherosclerosis due to favorable blood flow patterns.
During the four-month study, 15 male mice were given access to a voluntary running wheel. The mice were assigned to high-, moderate- and low-running groups based on their consistent running distances. Aortic tissues exposed to different blood flow patterns were collected to evaluate DNA damage and telomere function. The findings suggest the increased level of exercise later in life has a beneficial impact on DNA damage and telomere dysfunction.
There are many contributing factors to arterial aging. The driving factor among them is DNA damage. While more study in this area is needed, physiologists hope these findings lay the groundwork for improving human health in the future.
"By revealing the varied responses of aortic regions experiencing different blood flow patterns and cell types to aerobic exercise, this research will provide a firm ground on a detailed and customized approach to interventions for cardiovascular health," said Jisok Lim, Ph.D.
(Excerpt) Read more at medicalxpress.com ...
Telomere “length” is believed to be an indicator of aging, with longer being better.
Good to know; thanks.
So I see that exercise in late life was ineffective? Since when? I also see articles calling fitness “alt right” and “dieting” dangerous to your health too. I smell liberal big pharma.
So my DNA is in good shape, but my knees are shot.
30 minutes a day total on the stationary bike, elliptical and stairmaster.
No knee pounding.
I must be going for a positive mutation.
Yes, I finally switched to cycling (and swimming laps).
.
Nice to know I'm not alone. Bone on bone with an arthritic cyst in each knee. Fortunately cortisone shots do help. I'm hoping I die before I need knee replacements. Must have been the cheerleading, and fancy jumps that I did in my youth.
We (hub and I) are in an experiment that could prove this. We are in 70s. Did bio-energy testing in Dec. Started HIIT program based on test results and use heart rate as guide. My goal is 161 bpm for 2 min, my hubs is 144. 3 sets. We use ellipticals and also do some weights 3x week. (We have been pretty active most of our lives, but not athletic active). I have suffered weird chest pains for 35+ years...could never be figured out. They seem to be receding now, 4 months into this. It is interesting.
It could be that those which inherently have better telomeres are generally healthier and active. Maybe they don’t age as fast and so remain energetic longer.
It’s hard to tell the cause and effect here.
That said, remaining active can only benefit someone as they age and humans are capable of consciously choosing the lifestyle they engage in.
“exercise late in life is ineffective”.
I’m not seeing that statement in this article.
Are you making a point of how this info compares with other articles you have read?
3rd paragraph
Reread paragraph 3: Exercise late in life used to be thought ineffective.
Thanks, KC_
Be careful, I may have made a critical mistake. 3 years ago I would walk at 3.5 miles an hour. Every day since I have walked at least 3 miles a day since. Last year it was time for my 10 year tetanus vax, it was recommended I get shingles also so I did. I have since noticed I don’t have the same stamina, I did my walk at 3.0 miles today, and have walked over 3 a miles for over 1000 days continuous days in a row.
Is it just aging that has caused the slowdown? I’m not sure but I wish I had not taken the shingles dual vaxes as I had no issues with shingles.
Not sure if the vaxes have caused the slowdown or just old age getting to me. But based on the covid vax, I can’t trust vaccines anymore, and stopped all Flu vaxes. I can see my slowdown, just not sure why.
“Epithalon upregulates telomerase activity and elongates telomeres, with the effect of delaying aging processes in reproductive and immune systems and increasing the longevity of test subjects”
https://www.peptides.org/epithalon/
I’m approaching my 70’s.
I became interested in peptides and hormone therapy a while back, but never considered trying it until a couple years ago.
I started working with an osteopath, taking a mild dose of testosterone twice a week - and the difference in my attitude and mood is amazing. I also see results in energy levels and gym workouts. That alone was worth the cost of the hormones and quarterly lab work to monitor the effect(insurrance doesn’t generally cover this stuff).
I also started taking a peptide blend of Ipamorelin & CJC-1295. These are messengers that tell the pituitary to make more growth hormone. Science wise - your pituitary is quite capable of making growth hormone as you age - what breaks down is the peptide messenger that tells it how much to make.
YMMV, but I can attest to the effectiveness. It is not cheap when you work with a medical professional - about the same as a monthly car payment. There are folks that buy their own and self monitor.
Most peptides are injectables. That puts a lot of folks off. You need to be aware of health conditions that may be negatively affected by certain peptides.
There is scientific data backing up the effectiveness of many peptides. Some are in use and FDA aproved.
Good resources for more information: Search on - Jean Francois Tremblay - he has many great videos regarding anti-aging and healing aspects of peptide therapies:
https://duckduckgo.com/?q=jean+francois+tremblay&t=brave&ia=web
Fascinating stuff - but beware of the inevitable snake oil.
Subsequent to that, various health issues started to occur I had never before had, pretty much all at once. It was bizzare.
I did some research, and the idea anyone need a tetanus shot every ten years is not best practice, any more. From what I saw, it is better to do every 14 years as a practice, and the best thing to do is get your titers tested for the included vaccines. This one study showed people over 50 or so had so much tetanus immunity that they could go nearly two decades without another shot. Getting another smeith such strong immunity probably gives you a similar issue as six identical COVID vaccine shots, where it makes your immune system start to go nuts.
Not cool.
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