Posted on 03/31/2024 9:34:14 PM PDT by ConservativeMind
A five-day course of once-daily inorganic nitrate reduces the risk of a serious complication following a coronary angiogram, in which the dye used causes damage to the kidneys. The clinical trial also showed that the five-day course improves renal outcomes at three months and major adverse cardiac events (MACE) at one year compared to placebo.
Contrast-induced nephropathy (CIN), also known as contrast associated acute kidney injury (CA-AKI), is an uncommon but serious complication following coronary angiography. A special dye, which is visible on X-rays, is injected into the body and when the dye reaches the coronary arteries, an X-ray is taken.
While coronary angiography is safe for most people, some patients are at high-risk of CIN, which is a significant cause of death and critical illness for high-risk patients who have had coronary angiographic procedures. For older people and those with heart failure, chronic kidney disease (CKD) or diabetes with CKD, incidence of CIN can be as high as 55%.
One of the principal mechanisms underlying CIN is thought to be an increase of oxidative stress and the accompanying decrease in levels of protective nitric oxide (NO) in the body.
A group of 640 patients undergoing angiography for non-ST-elevation Acute Coronary Syndrome (ACS) (NSTE-ACS) took part in the trial, with 319 receiving once daily inorganic nitrate capsules (potassium nitrate) and 321 receiving a placebo capsule (potassium chloride). The study showed that patients receiving inorganic nitrate treatment had significantly reduced CIN rates (9.1%) vs. placebo (30.5%), lower rates of procedural myocardial infarction (2.7% vs. 12.5%), improved three-month renal function and reduced one-year major adverse cardiac events (MACE) (9.1% vs. 18.1%) compared to patients who had received the placebo treatment.
Contrast-induced nephropathy (CIN) is deemed responsible for a third of all hospital-acquired acute kidney injuries.
(Excerpt) Read more at medicalxpress.com ...
Regardless of this, make sure your iodinated contrast is warmed to body temperature, before being put in you. Warming to body temperature reduces its viscosity by 50%, which makes it much safer on your organs (it can be 13 - 23X thicker than blood).
...potassium nitrate...
Ain’t that found in bacon?
Nitrate? Bacon theory?
It requires due diligence.
Published a few months ago...
Prevention of Contrast-induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention
...Based on current definitions the incidence of contrast-induced nephropathy ranges from 2% to 30%...
Okaaaay...
FYI ping in case you should find this thread of interest.
WTG, Big Med.
I wish I’d have known about this before I had my heart stent, renal stents and other vascular related operations that involve that dye. I think I’d not be on dialysis now.
Potassium nitrate?
Saltpeter?.....................boom!................
If saltpeter is the answer, then I guess one needs to avoid Viagra for 5 days.
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