Posted on 02/05/2023 8:11:23 AM PST by ConservativeMind
Researchers have found that the association between heavy coffee consumption and kidney dysfunction hinges on a common genetic variation.
The researchers showed that markers of kidney dysfunction were nearly three times higher in heavy coffee drinkers with a variant of the CYP1A2 gene that makes them slow metabolizers of caffeine than for other heavy coffee drinkers who had a different version of the gene that enables faster caffeine metabolism.
"We think fast metabolizers can eliminate caffeine from their systems more efficiently and avoid harmful build-ups," said Ahmed El-Sohemy. "These individual differences in caffeine metabolism help explain why previous studies on coffee and kidney disease have been inconsistent."
The amount of caffeine a person consumes also appears to be important. For the current study, risk of kidney dysfunction was only significant in people who drank three or more cups of coffee a day, which is about 300 mg of Italian espresso. Current guidelines in Canada and the U.S. recommend no more than 400 mg per day for healthy adults.
The researchers also found that prevalence of the CYP1A2 gene variant that makes people slow metabolizers of caffeine was similar in both the study group and the general population: roughly 50%.
Many companies and clinics now include CYP1A2 in genetic tests.
"Heart disease, prediabetes and hypertension are all affected by variations in CYP1A2, which can also alter athletic performance," said Sara Mahdavi, lead author on the study and a former post-doctoral fellow in El-Sohemy's lab. "We can now be confident that whether or not coffee is deleterious to kidney health depends, in part, on CYP1A2."
The researchers studied three markers of kidney dysfunction: albuminuria (too much of the protein albumin in urine); hyperfiltration (high glomerular filtration rate in the kidney); and hypertension.
Estimates put the prevalence of kidney disease at about 13%.
(Excerpt) Read more at medicalxpress.com ...
May I ask what they treated you with?
And here I remember reading that coffee was a good cleansing mechanism for the liver and kidneys about 10-15 years ago.
Another BS science study I guess..
I remember that too, about 5-6 yrs ago.
I don’t trust any of these so-called “studies” or “reports”.
They all BS, depending upon who writes them, for which company or industry, and I always check the ‘fine print’ at the bottom of the article.
Totally agree my FRiend.
I will forever remain skeptical of “reports” and “studies”.
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