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Ketamine for Alcoholics Trial Goes to Next Stage
BBC ^ | 12/14

Posted on 12/13/2022 3:20:52 PM PST by nickcarraway

A programme of therapy involving the drug ketamine will be made available to alcoholics in a research project.

The University of Exeter-led trial, with funding of £2.4m, will go ahead at seven NHS sites across the UK.

The trial will look into whether a combination of ketamine and therapy could help alcoholics stay sober for longer.

Prof Celia Morgan, the academic behind the research, said there was an "urgent need" for new treatments.

The research will go ahead after a phase two trial showed ketamine and therapy treatment was safe and tolerable for heavy drinkers.

An earlier study found participants who had ketamine combined with therapy stayed completely sober, representing 86% abstinence in their six month follow-up.

The Ketamine for Reduction of Alcohol Relapse (KARE) trial will now move to the next step of drug development, with the aim of rolling it out into the NHS if it proves effective.

(Excerpt) Read more at bbc.com ...


TOPICS: Health/Medicine; Science
KEYWORDS: alcoholism; ketamine
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1 posted on 12/13/2022 3:20:52 PM PST by nickcarraway
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To: nickcarraway

I wonder what doses they will be using.

Ketamine has a very short half-life, and it causes hallucinations.


2 posted on 12/13/2022 3:23:05 PM PST by marktwain
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To: marktwain

Fetterman says, “Go for it!”


3 posted on 12/13/2022 3:25:10 PM PST by Mark (Celebrities... is there anything they do not know? Homer Simpson)
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To: marktwain

Doped up on Ketamine, rather than drunk.


4 posted on 12/13/2022 3:25:23 PM PST by Fido969 (45 is Superman! )
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To: Fido969

Probably not. For the depression, some of them only get an injection or an infusion once every few months.


5 posted on 12/13/2022 3:27:38 PM PST by nickcarraway
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To: nickcarraway
Yeah - quit your addiction to ethanol - and get addicted
physically and/or psychologically to ketamine instead.
It'll be fine. Hey - what's the worst that could happen?

Right?

6 posted on 12/13/2022 3:29:55 PM PST by GaltAdonis
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To: Fido969

Next week... “Alcohol seen as therapeutic for Ketamine Addicts”


7 posted on 12/13/2022 3:29:55 PM PST by irishjuggler
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To: nickcarraway

Yell me where they are in five years

There is a proven way to stay sober but many don’t want to try it because Hod is involved

Let ‘em drink themselves to death then

There is a way out

Twenty six years and counting. Happy to be sober another day


8 posted on 12/13/2022 3:30:46 PM PST by Nifster (OI see puppy dogs in the clouds )
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To: nickcarraway

Apparently, it works wonders for depression. Too expensive for my blood, though.


9 posted on 12/13/2022 3:33:56 PM PST by Flaming Conservative ((Pray without ceasing))
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To: nickcarraway

My doctor said sometimes it only takes one dose for depression.


10 posted on 12/13/2022 3:34:48 PM PST by Flaming Conservative ((Pray without ceasing))
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To: Flaming Conservative

Correct. I had a friend who was in a university trial for treatment-resistant depression. He had an injection, and it lasted three or four months.


11 posted on 12/13/2022 3:35:52 PM PST by nickcarraway
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To: nickcarraway

Kind of like elecroconvulsive therapy.

Also, notice “ An earlier study found participants who had ketamine combined with therapy stayed completely sober, representing 86% abstinence in their six month follow-up.”

How they don’t mention abstinence rate with therapy alone (or ketamine alone, for that matter).


12 posted on 12/13/2022 3:37:26 PM PST by ifinnegan (Democrats kill babies and harvest their organs to sell)
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Isn’t special K even more addictive than booze? I know it pretty much makes you positively incapable of functioning and being in any way remotely productive for a significant amount of time


13 posted on 12/13/2022 3:38:13 PM PST by dsrtsage ( Complexity is just simple lacking imagination)
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To: nickcarraway

One addiction to another ?


14 posted on 12/13/2022 3:38:45 PM PST by HollyB
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To: nickcarraway

15 posted on 12/13/2022 3:47:12 PM PST by monkeyshine (live and let live is dead)
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To: Flaming Conservative; All

“4.1 Interventions
KARE has two forms of intervention, a drug intervention and a psychotherapy intervention. The active drug intervention is ketamine, an anaesthetic/analgesic drug, to be administered intravenously. The placebo control

is saline. As well as a drug intervention the participants will receive concurrently either a psychotherapy intervention, or a psychoeducation control intervention. Hence, there are four combinations: (i) ketamine + psychotherapy; (ii) ketamine + psychoeducation; (iiI) placebo + psychotherapy; (iv) placebo + psychoeducation. Participants will receive their allocated drug infusion in 3 doses over 3 weeks. Participants will concurrently receive either psychotherapy or psychoeducation control. The trial will be performed at two sites: Devon (Royal Devon & Exeter Foundation NHS Trust) and London (UCLH).

https://clinicaltrials.gov/ProvidedDocs/31/NCT02649231/SAP_001.pdf


16 posted on 12/13/2022 3:51:16 PM PST by HollyB
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To: HollyB; dsrtsage; irishjuggler; GaltAdonis

The therapy likely won’t require the patient to get addicted. It will probably be given in the doctor’s office.


17 posted on 12/13/2022 3:52:49 PM PST by nickcarraway
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To: nickcarraway

Next, they’ll try meth.


18 posted on 12/13/2022 3:56:13 PM PST by familyop ("For they that sleep with dogs, shall rise with fleas" (John Webster, "The White Devil" 1612).)
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To: nickcarraway
"It will probably be given in the doctor’s office."

.

Oh, that's okay then.
Doctors never screw-up.

And patients never go to multiple doctor's to 'double-up'
or obtain additional off of the street.

Luckily these awful things never, ever happen.

/s

19 posted on 12/13/2022 4:17:21 PM PST by GaltAdonis
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To: nickcarraway

Agree. I just read over the trial info. It’s posted just an bit above.


20 posted on 12/13/2022 4:20:38 PM PST by HollyB
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