Posted on 08/27/2022 6:14:13 PM PDT by ConservativeMind
A three-drug medication known as a "polypill" is effective in preventing secondary adverse cardiovascular events in people who have previously had a heart attack, reducing cardiovascular mortality by 33 percent in this patient population.
"The results of the SECURE study show that the polypill, which contains aspirin, ramipril, and atorvastatin, achieves clinically relevant reductions in the recurrent cardiovascular events among people who have recovered from a previous heart attack because of better adherence to this simplified approach with a simple polypill, rather than taking them separately as conventional," says Dr. Fuster.
Patients recovering from a heart attack—also known as myocardial infarction—are prescribed specific treatments to prevent subsequent cardiovascular events. Standard therapy includes three different drugs: an antiplatelet agent (like aspirin); ramipril or a similar drug to control blood pressure; and a lipid-reducing drug, such as a statin. However, fewer than 50 percent of patients consistently adhere to their medication regimen.
CNIC scientists demonstrated that prescription of their polypill significantly improved treatment adherence among patients recovering after a myocardial infarction, in the FOCUS study.
The CNIC team launched the SECURE study to determine whether the improved treatment adherence with the polypill translated into a reduction in cardiovascular events. The polypill analyzed in the study, commercialized under the name Trinomia, contains aspirin (100 mg), the angiotensin-converting enzyme inhibitor ramipril (2.5, 5, or 10 mg), and atorvastatin (20 or 40 mg).
Researchers analyzed the incidence of four major cardiovascular events: death from cardiovascular causes, non-fatal myocardial infarction, non-fatal stroke, and need for emergency coronary revascularization (the restoration of blood flow through a blocked coronary artery). The study followed patients for an average of three years and produced conclusive results: patients taking the CNIC polypills had a 24 percent lower risk of these four events than patients taking the three separate drugs.
(Excerpt) Read more at medicalxpress.com ...
Very strange.
2,499 patients from seven European countries (Spain, Italy, Germany, the Czech Republic, France, Poland, and Hungary)
CM thanks!
I have two prescriptions, and one I consistantly forget to take on time. (Not for heart attack.) The other, 80mg asprin, a blood thinner, I ignore and take Nattokinase instead.
A far better ACE inhibitor proven by the Vascular Biology Working Group of the University of FL would be the most tissue bound ACE inhibitor (ACE inhibition having been discovered in a South American viper discovered by Victor Dzau, MD, PHD).. Quinapriil (Brand Name Accupril, Parke Davis & Co, USP).
Quinapril, as part of the entire Vascular Biology preventative regimen, which includes the other two mentioned medications here- for prevention of cardiovascular disease, including prevention of Myocardial Infarction (MI), or heart attack.
This revelation was through the study of the largest organ of the body— defined as entire endothelium (cells lining) of the arterial/arteriole system of a human body. The surface area of this endothelium inside each artery/arteriole, if these cells were to be calculated to be spread in a single cell layer on a flat surface— would create an area the size of 7 tennis courts.
Surface area increased from its many micro parts (not unlike calculating the surface area of an automobile’s radiator’s “fins” compacted along the central cooling tubes of a the radiator (it is a very large cooling surface for the air to pass over and cool)- such that the increased surface area of arteries/arterioles represents the increased ability to exchange oxygen from red blood cells to all vital organs.
The brilliance of the biological genius who created the human body— yes HE who must have his name capitalized and never lower case.
I was taking nattokinase, which is amazing, but it dropped my bp 15 points, which was too low.
I do take Arjuna, which is amazing for almost every heart issue.
What benefits do you get from Arjuna? Never heard of it. My doctor is pressuring me to use a statin due to “high” cholesterol, but I do not want to do that.
Come on, man - evolution is amazing! /s
contains aspirin, ramipril, and atorvastatin
~~~~~~~~~~~~~~~~~~~
I will hypothesize the aspirin achieves 90% of the benefit by itself. The rest are a moneygrab.
...,but I do not want to do that.
I decided I didn’t want to do that years ago. Being in a wheel chair didn’t have my interest. Askapatient Is your friend, observe what it did to others. I have a mildly messed up Hip joint at my age because I “trusted”. https://www.askapatient.com/
Snake poison, I don’t think so...I’ll pass.
A dry cough for someone who has lung problems. Yes, that’s the ticket. s/
Re their meds: Refusing, forgetting to take, losing, running out of, etc. Also, simply deciding they dislike the prescribing doctor.
My guess is YES, there are that many people. Whole lotta bad patients out there.
Sticks hand up, lol.
Some info about Arjuna health benefits
https://dwarkadhishholisticcentre.org/2020/06/01/arjuna-in-heart-disease/
In addition, I have worked to make sure I’m giving my heart the nutrition it requires
I was low in thyroid and fixed that
No bad oils
Koncentrated K
Finally I decided that my new life would be walking 30 minutes a day, 5x/week. I started slowly. Over the last year I’ve gradually started moving it up to the point where I walk 40 minutes most days. Nothing heroic. About 2.3 mph.
Book: Younger Next Year
Completed my first year of walking and starting my second year now. I’ve come to enjoy it.
Just had the most complete blood panel of tests I’ve ever taken. Everything in normal range.
I feel good and am very grateful.
👍🏻👍🏻
Not anywhere near the concentration of the viper. The chemical affect of the viper’s bite is to reduced the blood pressure of it’s prey so low as to kill the mammal.
Controlled synthetic Angiotensin Converting Enzyme results in tissue level minute reductions in blood pressure naturally (just as ACE itself localizes the blood pressure needed by a person to stand up, run (run away from a predator) walk, maintain balance) and maintain blood oxygen to vital organs.
Nobel Prize for Medicine- for this discovery several decades ago.
Not “snake poison”. Read about it: https://en.wikipedia.org/wiki/Discovery_and_development_of_ACE_inhibitors
Should also mention that the use of an ACE inhibitor down regulates the mode of infection of coronavirus, which is “infected” into a person through the ACE receptors of the lungs- engaged by the S-spike protein of a virus inserted into the ACE receptor on the lung lining— and voila- in comes the massive content, the long strand of RNA that codes for the virus— replicated in each successive cell of the lung, killing each. An ACE inhibitor drug, or an ACE blocker drug prevents the Spike S protein from inserting.
Study of the snake’s poison enabled the understanding of the entire human cardio-vascular endothelium and the means by which Oxygen carried in red blood cells—gets to the critical organs that keep us all alive.
I know, you still need to have enough blood pressure to per-fuse your organs and not have dizzy spells! I could afford to get mine down a bit more. If I were to lose 25 pounds that would probably resolve the problem!
I think you expressed it well.
My normal Bo is ~117/75
I had a doctor try to prescribe bp meds!
Ya need blood!
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