Vitamin D may restore the body's natural barrier against ovarian cancer

Medical Xpress / Nagoya University / Matrix Biology ^ | May 31, 2022 | Kazuhisa Kitami et al

[ConservativeMind]

Ovarian cancer has one of the highest death rates of all cancers. One reason for this is that the cancer turns the body's defenses against itself. However, new research suggests that vitamin D can effectively prevent one of the key pathways used by this cancer.

Ovarian cancer often undergoes a process called peritoneal metastasis. In this process, its cells detach from their primary site in the ovary and travel to a secondary implantation site, such as the peritoneal wall or diaphragm. The peritoneum defends against this process using a barrier consisting of mesothelial cells, which prevent the adhesion of cancer cells and limit their spread. However, ovarian cancer gets around this defense by transforming the protective mesothelial cells into cancer-associated mesothelial cells. This creates an environment that helps metastasis, assisting the spread of cancer around the body.

The group, led by Dr. Masato Yoshihara, found that vitamin D not only counteracted this process but also restored cancer-associated mesothelial cells to their original state. This process strengthened the barrier effect of mesothelial cells and reduced further spread of the cancer. Their study suggests that vitamin D therapy may be a useful addition to the treatment of ovarian cancer.

Said Dr. Kazuhisa Kitami: "This study's most interesting point is that in situations where early detection of ovarian cancer is still extremely difficult, we showed that the peritoneal environment can be restored to its normal state where it prevents the adhesion and growth of cancer cells."

Dr. Kitami explains: "The administration of Vitamin D helps normalize the peritoneal environment. This suggests that the combination of Vitamin D and conventional remedies can enhance their therapeutic efficacy for ovarian cancer. We think this helps prevent the adhesion of cancer cells to the peritoneum, which may make it possible to prevent the recurrence of ovarian cancer."

[ConservativeMind]

Having a reasonable amount of Vitamin D can prevent long-term cancer issues, before you ever knew you had it.

[ConservativeMind]

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[Carriage Hill]

I take 5,000 IU/ day, along with 46 other Rxs and OTCs, split am/pm. Sucks to be me.

Rx Meds (5.27.2022):
Eplerenone 50 Mg Tablet
Lisinopril 5 Mg Tablet
Prednisolone Acetate 1 % Eye Drops, suspension
Pacerone 100 Mg Tablet
Metformin 1,000mg
Nitroglycerin 0.4 Mg Sublingual Tablet
Furosemide 40 Mg Tablet
Amlodipine Basylate 10mg
Doxycycline Hyclate 100 Mg Capsule
Lorazepam 1 Mg Tablet
Valium 10mg
Ondansetron 4 Mg Disintegrating Tablet
Zolpidem ER 12.5 Mg Tablet, Extended Release
Finasteride 5 Mg Tablet
Cyclobenzaprine 10 Mg Tablet
Metoprolol Succinate Er 50 Mg Tablet, Extended Release 24 Hr
Pantoprazole 40 Mg Tablet 2x/day
Combivent Respimat 20 Mcg-100 Mcg/actuation Solution For Inhalation
Meloxicam 15 Mg Tablet
Tamsulosin 0.4 Mg Capsule
Tramadol 50mg
Nystatin 100,000 Unit/ml Oral Suspension
Furosemide 20 Mg Tablet
Methylprednisolone 4 Mg Tablets In A Dose Pack
Cholecalciferol (vit D3) 1,000 Unit-vitamin K2 (mk4) 100 Mcg Tablet
Gabapentin 300mg (Peripheral Neuropathy in feet)
Atorvastatin 80 Mg Tablet
Entresto 97/103mg, 2x/day
Jardiance 25mg
Carvedillol 25mg

OTC Meds:
Aspirin Coated 81mg
Centrum Silver Multi-Vitamin
Phillips Probiotic
Zinc 50mg
Vitamin D3 5,000units
Vitamin B-1 100mg
Prevagen
Presser Eye Vitamins
Vitamin C 1,000mg
Magnesium 500mg
COQ10 100mg
Quercetin 500mg
Solomon’s Seal 1,000mg
Camu Supreme 2,650mg
Grape Seed Extract 300mg
Fish Oil 1,000mg

[ProtectOurFreedom]

Wow, every day Vitamin D appears to be more and more a true wonder drug.

[Jane Long]

Quite a list!

Are some of these temporary?

It has to be a challenge, just keeping track of bottles, dosages, etc.

[RedMonqey]

How do you carry all those drugs?

Tractor-trailer or C130 airlift?

[ProtectOurFreedom]

“Sucks to be you”? Nah, you’re still above ground and here with your FRiends. That never sucks.

[Secret Agent Man]

vitamin d is actually a hormone

a master hormone, really

involved in thousands of processes in your body

its that important

its why we synthesize it by skin sun exposure

[Carriage Hill]

The Rxs are until forever; I’m 72. I can drop the OTCs but so far I haven’t had Covid or so much as a cold.

I’ve got these too.

Co-morbidities:
1) Heart left ventricle (pumping at 55-60%; up from 20-25%),
2) Heart bundle blockage (5 stents),
3) Diabetes (Type 2, down from Type 1),
4) Hypertension (under control w/ Rx),
5) Weight (down from 265 to 165lbs),
6) COPD (under control w/ emergency inhaler),
7) Stage 2 Mild Kidney Disease (medication & diet controlled).

[Carriage Hill]

Lockheed C-5 Galaxy. Heh.

[Carriage Hill]

Many kind thanks, FRiend.

[Jewbacca]

So going outside and having a life is healthy.

Shocker.

It’s almost like we have a designer.

[ConservativeMind]

That is quite a list. I am glad it is helping you, but saddened for the sheer numbers of medicines involved.

I would hope you could minimize or eliminate some of those, but it would take a few doctors time to sort it all out.

I know someone who went from over 25 prescriptions from the VA to just one. He had been overmedicated for years and was given meds to counter side effects, to then get meds to counter the new drugs’ side effects.

He's doing fine, now.

[Mark17]

Vitamin D is effective against ovarian cancer? That’s good news for those skanky democrat men, who claim to have one. /S

[Jane Long]

God bless you!

The improvements are impressive.

Good job on the weight loss....100 lbs. is a lot to lose.

[ProtectOurFreedom]

Congrats on the huge weight loss! I was up to 203 and am down to 183 now, but would love to keep it going to 170 or so. Seems I’ve plateaued for a while in the low 180s.

[Jane Long]

We had a family friend in a similar situation. The right doc got her MANY meds, with many issues, down to one or two.

She lived a long and happy life...especially once her meds were adjusted, correctly.

Crazy the snowball effect that can happen.

[ConservativeMind]

Can I ask what is causing the pain you have? Also, what is the reason for your steroids? Finally, did you note a reason for stomach acid issues?

[ConservativeMind]

We know similar stories!

[sauropod]

.