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Real-world evidence for improved outcomes with histamine antagonists and aspirin in 22,560 COVID-19 patients
Nature.com ^ | June 2021 | Signal Transduction and Targeted Therapy Staff

Posted on 02/04/2022 11:29:52 AM PST by CondoleezzaProtege

The COVID-19 pandemic has driven great interest in the therapeutic potential of repurposed drugs with well-established benefits and safety profiles (toxicity, bioavailability, etc.), many of which act via signal transduction pathways.

One category of such drugs is those that reduce acid production in gastroenterological contexts. Acid-suppressing drugs belong to two main classes, based on their mechanisms of action: (i) proton-pump inhibitors (PPIs) sterically block H+/K+-ATPase pumps, impeding the final step of acid release in the gastric mucosa. (ii) Histamine H2 receptor antagonists (H2RA) competitively bind the H2R, a type of G-protein coupled receptor (GPCR),1 and block the natural stimulation of its downstream signal transduction cascade by histamine; famotidine (e.g., Pepcid®) and ranitidine (e.g., Zantac®) are exemplary H2RAs.

A dense web of functional linkages exists between histamine and H2RAs, on the one hand, and disparate physiological pathways on the other hand. These downstream signaling pathways include gastrointestinal systems (acid reduction) as well as the dysregulated inflammatory cascades (cytokine storm) that likely underlie much of the pathophysiology of COVID-19.

(Excerpt) Read more at nature.com ...


TOPICS: Health/Medicine
KEYWORDS: antivirus; homeopathic; hometreatment; otc; preventative; proactive


1 posted on 02/04/2022 11:29:52 AM PST by CondoleezzaProtege
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To: CondoleezzaProtege

How much would that drug cocktail cost me at Dollar General?


2 posted on 02/04/2022 11:36:09 AM PST by crusty old prospector
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To: CondoleezzaProtege

It kind of creeps me out that there was someone on the Godlikeproductions website back in January of 2020 that was warning people about Covid and what they should stock up on...benadryl, pepcid, etc...and explained why

And turns out he was right.


3 posted on 02/04/2022 11:39:05 AM PST by RummyChick
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To: RummyChick

here’s the post:

“I know things... this is not Uncle intel,...
I work in Biohazard remediation and mitigation for a living. I specialize in disaster sites where a large number of people have passed and ensuring the site is safe for people to enter. (Think Hurricane Katrina) Places where there are cadavers, many; rotten, festering, wanting to harm others. Places that have been underwater for so long that the very walls are lined from end to end with toxic mold. So I have a inside line to people and things I cannot elaborate on

xxxx,

The Corona-virus is tearing it’s way across the world, and it is truly much worse than “they” are letting on. Is a big deal and I am afraid it may become a MUCH bigger deal.

You need to go to the store and buy one of these: Pepcid, Tagamet, Adix, or Zantac.
Buy enough for you, xxxxx, xxx, and whoever you want to save, enough last 2 weeks.
This covers your H2 antagonist drug.

Buy enough Prilosec, Prevacid. or Nexium to do the same as above.

This covers the PPI Drugs. (Proton Pump Inhibitors)

Lastly, I’d buy a big ass bottle of benadryl or generic benadry. aka... diphenhydramine.
This covers your need for a H1 antagonist.

You know what benadryl does. But the H2 drugs work in the same way except on different histamines. The PPI (Proton Pump Inhibitor) stops monocytes from going into overdrive. (Monocytes = White Blood Cells)
The Coronavirus hits in a similar way to the flu. As it is a “Novel Virus” meaning the body has never seen anything like this... the body goes nuts, to the point that your own immune system kills you in something called a Cytokine Storm.

This is very similar to a “Peanut Allergy”, in that it’s the bodies response that damages the person not the peanuts.

When to start this “therapy”? No need to take anything in advance. But at the first sign of “flu like symptoms” I’d start therapy. Take it as directed on the box.

You’ll read and hear about it on the news. Obviously!
What makes this virus “The Perfect Storm” is that it:
1. Has up to a 14 day incubation period.
2. The infected start shedding the virus in as little as 5 days after exposure.
3. Is as adaptable as the common cold. Meaning that about after each 3rd generation, the virus mutates into something that would require a completely different vaccination.

We could literally ALL have this virus and not know it.

I’m not freaking out, I’m not making a big deal out of nothing. You can google everything I’ve brought up.

Now for the conspiracy theory portion of my presentation. Whether you know it or not. There have been SEVERAL recalls of various anti-acid drugs in the past few months. (Once again, you can research this) Maybe we knew this was coming and we have been stockpiling.
Yes, hospitals will give you prevacid and pepcid if you have the Corona-virus.
Just sayin’.
Love, Me”


4 posted on 02/04/2022 11:41:57 AM PST by RummyChick
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To: RummyChick

Dang, girl....how did you find that so fast? You must have a heck of a filing system, on your computer. Kudos, to you!


5 posted on 02/04/2022 11:45:06 AM PST by Jane Long (What we were told was a “conspiracy theory” in 2020 is now fact. 🙏🏻 Ps 33:12)
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To: CondoleezzaProtege

Remember, granting an EUA depends on the lack of any other available treatment.

Zantac was pulled nationwide just as COVID was becoming concerning in early 2020.
HCQ was deemed a fish-bowl cleaner [by the media].
IVM was called “horse dewormer” [by the media].

Science.


6 posted on 02/04/2022 11:53:44 AM PST by Cletus.D.Yokel (This is NOT a pandemic of the unvaxx'd. It is a complete loss of common sense.)
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To: RummyChick

Excelsior!
Is this an FR post or a social media post...do you recall?


7 posted on 02/04/2022 11:59:01 AM PST by Cletus.D.Yokel (This is NOT a pandemic of the unvaxx'd. It is a complete loss of common sense.)
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To: CondoleezzaProtege

good post. pepcid works.


8 posted on 02/04/2022 12:00:23 PM PST by dadfly
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To: Cletus.D.Yokel

Hindsight is sometimes revealing


9 posted on 02/04/2022 12:01:14 PM PST by algore
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To: CondoleezzaProtege

lol, even my vet has prescribed it for my cat.


10 posted on 02/04/2022 12:01:29 PM PST by dadfly
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To: Cletus.D.Yokel

And this, in case anybody is still contemplating getting the jab.

https://www.rochesterfirst.com/coronavirus/i-dont-know-what-else-to-do-or-where-to-even-go-from-here-covid-19-vaccine-to-blame-for-southern-tier-mans-death/


11 posted on 02/04/2022 12:11:09 PM PST by Nella
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To: Cletus.D.Yokel

it’s from Godlikeproductions.com in January of 2020. It’s a conspiracy website. I read it often to see what news is out there. They post stuff there fast...and well then...things can sometime get crazy.

That post is so creepily accurate it makes me wonder who it was and who he had access to way back at the beginning of it all.


12 posted on 02/04/2022 12:11:40 PM PST by RummyChick
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To: CondoleezzaProtege

Ten bucks.


13 posted on 02/04/2022 12:14:43 PM PST by irishjuggler
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To: RummyChick

The thing that I find interesting about this is that my doctor wants me to take Benadryl and Pepcid AC first whenever I get a bee or wasp sting BEFORE I use my epi-pen. So far, I’ve had to do it twice, and never needed the epi-pen after all. The hives and the allergic reaction seem to stop dead in their tracks. Of course, the Benadryl makes me drowsy, so I need to make sure I’m not going to be driving when I take them.


14 posted on 02/04/2022 12:40:35 PM PST by FamiliarFace
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To: FamiliarFace

You must not have the really fast violent reaction. Those kind of people wouldnt have time for the Pepcid and Bendryl to react to the histamines.


15 posted on 02/04/2022 12:48:51 PM PST by RummyChick
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To: RummyChick

I’m guessing not. The doc said at my age, the epipen wouldn’t be easy on me, which is why he recommended the other two first.


16 posted on 02/04/2022 12:53:31 PM PST by FamiliarFace
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To: All

So Pepsid,Prylosec and Benedryl will mitigate virus symptms?
article didn’t make much sense to me ....
tested on 22k ? which variant and when?
is this with or without aspirin?


17 posted on 02/08/2022 12:11:17 PM PST by CarolinaReaganFan
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