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NIH National Library of Medicine: Therapies to Prevent Progression of COVID-19, Including Hydroxychloroquine, Azithromycin, Zinc, and Vitamin D3 With or Without Intravenous Vitamin C: An International, Multicenter, Randomized Trial
CUREUS: NIH National Library of Medicine: National Center for Biotechnology Information ^ | 11/25/2021 | Karin Ried, Taufiq BinJemain ,and Avni Sali

Posted on 01/20/2022 8:41:23 PM PST by SeekAndFind

Abstract

Background

COVID-19 is a global pandemic. Treatment with hydroxychloroquine (HCQ), zinc, and azithromycin (AZM), also known as the Zelenko protocol, and treatment with intravenous (IV) vitamin C (IVC) have shown encouraging results in a large number of trials worldwide. In addition, vitamin D levels are an important indicator of the severity of symptoms in patients with COVID-19.

Objectives

Our multicenter, randomized, open-label study aimed to assess the effectiveness of HCQ, AZM, and zinc with or without IVC in hospitalized patients with COVID-19 in reducing symptom severity and duration and preventing death.

Methods

Hospitalized patients with COVID-19 in seven participating hospitals in Turkey were screened for eligibility and randomly allocated to receive either HCQ, AZM, and zinc (group 1) or HCQ, AZM, zinc plus IV vitamin C treatment (group 2) for 14 days. The patients also received nontherapeutic levels of vitamin D3.

The trial is registered on the Australian and New Zealand Clinical Trial Registry ACTRN12620000557932 and has been approved by the Australian Therapeutic Goods Administration (TGA).

Results

A total of 237 hospitalized patients with COVID-19 aged 22-99 years (mean: 63.3 ± 15.7 years) were enrolled in the study. Almost all patients were vitamin D deficient (97%), 55% were severely vitamin D deficient (<25 nmol/L) and 42% were vitamin D deficient (<50 nmol/L); 3% had insufficient vitamin D levels (<75 nmol/L), and none had optimal vitamin D levels.

Of the patients, 73% had comorbidities, including diabetes (35%), heart disease (36%), and lung disease (34%).

All but one patient (99.6%; n = 236/237) treated with HCQ, AZM, and zinc with or without high-dose IV vitamin C (IVC) fully recovered. Additional IVC therapy contributed significantly to a quicker recovery (15 days versus 45 days until discharge; p = 0.0069).

Side effects such as diarrhea, nausea, and vomiting, reported by 15%-27% of the patients, were mild to moderate and transient. No cardiac side effects were observed.

Low vitamin D levels were significantly correlated with a higher probability of admission to the intensive care unit (ICU) and longer hospital stay.

Sadly, one 70-year-old female patient with heart and lung disease died after 17 days in ICU and 22 days in the hospital. Her vitamin D level was 6 nmol/L on admission (i.e., severely deficient).

Conclusions

Our study suggests that the treatment protocol of HCQ, AZM, and zinc with or without vitamin C is safe and effective in the treatment of COVID-19, with high dose IV vitamin C leading to a significantly quicker recovery.

Importantly, our study confirms vitamin D deficiency to be a high-risk factor of severe COVID-19 disease and hospitalization, with 97% of our study’s patient cohort being vitamin D deficient, 55% of these being severely vitamin D deficient, and none had optimal levels.

Future trials are warranted to evaluate the treatment with a combination of high-dose vitamin D3 in addition to HCQ, AZM, and zinc and high-dose intravenous vitamin C.

CLICK ON THE ABOVE STUDY LINK FOR THE DETAILS



TOPICS: Health/Medicine; Science; Society
KEYWORDS: covid; covid19; covidinfo; hcq; hydroxychloroquine; therapy
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1 posted on 01/20/2022 8:41:23 PM PST by SeekAndFind
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To: ransomnote; Cathi; metmom; grey_whiskers; bagster; tatown; Enlightened1; cgbg; SecAmndmt; ...
Our study suggests that the treatment protocol of HCQ, AZM, and zinc with or without vitamin C is safe and effective in the treatment of COVID-19, with high dose IV vitamin C leading to a significantly quicker recovery.

Yet the b@$t*rds kept this EXACT treatment, which RPOTUS also suggested EARLY ON, from the American people ping. 😡

2 posted on 01/20/2022 8:46:32 PM PST by Jane Long (What we were told was a “conspiracy theory” in 2020 is now fact. 🙏🏻 Ps 33:12 )
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To: SeekAndFind

How many millions died waiting for this?


3 posted on 01/20/2022 8:48:04 PM PST by Uncle Miltie (How many were shot dead at the insurrection?)
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To: SeekAndFind

First time I’ve seen report of being vitamin D deficient if under 75!!! I’ve said for years docs who don’t test vit d levels are DEFICIENT.


4 posted on 01/20/2022 8:52:08 PM PST by goodnesswins (....pervert Biden & O Cabal are destroying America, as planned.)
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To: gas_dr

Refute this.


5 posted on 01/20/2022 8:52:09 PM PST by Uncle Miltie (How many were shot dead at the insurrection?)
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To: Uncle Miltie

Impressive argument.


6 posted on 01/20/2022 8:59:40 PM PST by gas_dr (Conditions of Socratic debate: Intelligence, Candor, and Good Will. )
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To: gas_dr

I agree the thoroughly documented study is impressive. Demonstrates malfeasance by governments unwilling to study this approach literally over a year ago.


7 posted on 01/20/2022 9:03:44 PM PST by Uncle Miltie (How many were shot dead at the insurrection?)
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Comment #8 Removed by Moderator

To: SeekAndFind

Whenever it comes up, I like to point out to the medical snobs who like to throw around the words “horse paste” that I make it a point to make sure I take a daily dose of poultry supplement (that would be vitamin D) and swine analgesic (aspirin).


9 posted on 01/20/2022 9:16:18 PM PST by Stosh
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To: SeekAndFind

bttt


10 posted on 01/20/2022 9:34:22 PM PST by linMcHlp
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To: Uncle Miltie
How many millions died waiting for this? -— About 5 million worldwide. A world class expert Yale Med School infectious disease doc says the anti covid therapeutic drug suppression has cost 500,000 lives - as of a year ago. Much higher now.
11 posted on 01/20/2022 9:36:29 PM PST by rdcbn1
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To: goodnesswins

I’ve said for years docs who don’t test vit d levels are DEFICIENT.....

In defense of the MD’s, many insurances won’t pay for routine testing.


12 posted on 01/20/2022 10:04:54 PM PST by Ceebass (USA RIP 1776-2021)
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To: Jane Long

They WILL answer to God for that.

The blood of tens of thousands are on their hands.


13 posted on 01/20/2022 10:13:18 PM PST by metmom (...fixing our eyes on Jesus, the Author and Perfecter of our faith….)
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To: Stosh

A little of that horse paste in the hollow of half a Tangerine is so Purdy, lol. Breakfast of champions.


14 posted on 01/20/2022 10:22:03 PM PST by OftheOhio (never could dance but always could fight - Romeo company)
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To: SeekAndFind

Great info. Thanks for posting.


15 posted on 01/20/2022 11:28:58 PM PST by Sloopy
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To: SecAmndmt; datura; Fractal Trader; bagster; grey_whiskers; metmom; Jane Long; tatown; ...

PING


16 posted on 01/21/2022 12:22:11 AM PST by ransomnote (IN GOD WE TRUST)
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To: Jane Long

They purposely avoided Ivermectin?


17 posted on 01/21/2022 2:19:19 AM PST by JohnnyP (Thinking is hard work (I stole that from Rush).)
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To: goodnesswins

We have long supplemented and rated sufficiency for vitamin D far too low! It has been understood that a level of 25 is required to prevent rickets and 30 has long been considered sufficient. Labs are now more likely to bump that up to 40.

https://www.health.harvard.edu/blog/vitamin-d-whats-right-level-2016121910893#:~:text=At%20that%20time%2C%20their%20experts,for%20both%20children%20and%20adults.%22


18 posted on 01/21/2022 2:49:46 AM PST by 9YearLurker
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To: Stosh

That is brilliant!


19 posted on 01/21/2022 5:07:10 AM PST by ViLaLuz (2 Chronicles 7:14)
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To: Uncle Miltie
CUREUS: NIH National Library of Medicine: National Center for Biotechnology Information ^ | 11/25/2021 | Karin Ried, Taufiq BinJemain ,and Avni Sali .......

.... 11/25/2021 .....

20 posted on 01/21/2022 5:34:28 AM PST by urtax$@work
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