Posted on 04/15/2019 10:51:07 AM PDT by DUMBGRUNT
How does increasing cannabis use affect medical care? Researchers at Community Hospital in Grand Junction, Colorado, explored one small area of medical care: sedation. They examined the medical records of 250 patients who received endoscopic procedures between January 1, 2016, and December 31, 2017 -- years after the state legalized recreational marijuana in 2012. Comparing cannabis users to nonusers, they found that patients who reported smoking or using edibles on a daily or weekly basis required 14% more fentanyl, 20% more midazolam and 220% more propofol to achieve optimum sedation for routine procedures, including colonoscopies. For example, it took 13.83 milligrams of propofol, on average, for 225 nonusers to float into unconsciousness, compared with 44.81 milligrams needed, on average, by 25 cannabis users.
(Excerpt) Read more at cnn.com ...
Bring Your Own Anaesthetic
Or they could just toke up some Purple Punch or Afghan Kush before going in.
Not the joke I thought it would turn out to be.
In summary, our results confirm anecdotal clinical impressions that anesthetic requirement is greater in redheads. The observed 19% difference between the two groups makes red hair a distinct phenotype that correlates with inhalational anesthetic requirement in humans and can be traced to a specific genotype.
“,,,,and the occasional
Acid FlashBack.”
Am wondering if or how this study accounted for that.
So what?
What about alcoholics?
From the article:
Dr. Roderic Eckenhoff, a professor of anesthesia at the University of Pennsylvania, said the study is interesting but lacked rigor. “I would consider this a pilot study that maybe somebody should pick up on and do a more complete trial,” said Eckenhoff, who was not involved in the research.
One factor that bothered him was that the study was retrospective: The researchers simply examined medical records and compared whatever amount of sedation was used for each patient instead of controlling exact amounts of sedation and comparing the effects.
What is considered “enough” depends a lot on the individual providers and surgeons involved, Eckenhoff said. This “uncertainty” combined with a small number — just 25 — of cannabis-using patients makes the results “really tenuous at best,” he said.
Similar results have not been seen in previous research, he said: “Even if you give someone propofol for a long time, they get a little tolerant to it, but not by 200%.” Although upward of 200% “resistance” may be “possible, I’d be surprised if that held up in a bigger study,” he said.
Finally, he noted that patients are not always reliable and don’t necessarily tell their doctors about “everything else that they take,” and this may have influenced the results: “Some people who use marijuana also take other drugs recreationally.”
I wonder if this has anything to do with the articles I read that postulated that redheads have a greater abundance of Neanderthal genes.
I always knew it. Dope smokers have stronger brains.
Folks who have been on long term opioid and or benzos (like xanax or valium) are very difficult to sedate.
“Or they could just toke up some Purple Punch or Afghan Kush before going in.”
Pineapple Kush, mon.
I’ll check leafly. Both of those were designed for sleeping.
The vendors in DC have a $100 minimum. It looks like I’ll be smoking local ditch weed.
Exactly.
Or maybe marijuana users actually do have less tolerance for pain, because they experience it less often.
it makes sense. I’m probably using the wrong terms but thc binds to the opiate receptors so the more receptors are ‘occupied’ the less ‘vacant’ ones for the pharmaceutical opiates to attach to.
Not just inhalational, red heads need more local anesthesia too.
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