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Beware Of Eating Grapefruit With Any Of These 32 Common Drugs
BI ^ | 3-20-2017 | Dr. Matthew Thorpe, MD, PhD, Authority Nutrition

Posted on 03/20/2017 2:47:38 PM PDT by blam

Note: This article contains general information — not specific medical advice. Talk to your physician before changing your use of any medication.

Grapefruit is a delicious citrus fruit with many health benefits.

However, it can interact with some common medications, altering their effects on your body.

If you're curious about the grapefruit warning on many medicines, this article will help you understand why it's there and what your options are.

Here's a closer look at 32 common drugs that may have dangerous interactions with grapefruit.

How does it interact with medications?

How does it interact with medications?

Medications are processed in your liver and small intestine by a specialized group of proteins called cytochrome P450 (CYPs).

CYPs break down medications, reducing the blood levels of many of them.

Grapefruit and a few of its close relatives, such as Seville oranges, tangelos, pomelos and Minneolas, contain a class of chemicals called furanocoumarins.

Furanocoumarins disrupt the normal function of CYPs. In fact, studies show that they increase the blood levels of over 85 medications (1).

By slowing down the way in which CYPs normally break down medications in your gut and liver, grapefruit can increase the side effects of these drugs (1).

There are three things to know in order to understand if and how you can safely consume grapefruit with these medications.

1. It doesn’t take much: One whole grapefruit or one glass of grapefruit juice is enough to alter how these medications affect you.

2. It lasts several days: Grapefruit’s ability to affect medication lasts for 1–3 days. Taking your medication a few hours apart from consuming it isn’t long enough.

3. It’s significant: For a small number of drugs, grapefruit’s effects can be serious.

(snip)

(Excerpt) Read more at businessinsider.com ...


TOPICS: Food
KEYWORDS: citrus; drugs; grapefruit; medications
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1 posted on 03/20/2017 2:47:38 PM PDT by blam
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To: blam

And not just grapefruit, can be cranberry juice or other.


2 posted on 03/20/2017 2:49:03 PM PDT by ifinnegan (Democrats kill babies and harvest their organs to sell)
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To: blam

Absolutely! Until my hubby developed diabetes, I made ruby grapefruit juice every morning.


3 posted on 03/20/2017 2:49:42 PM PDT by miss marmelstein
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To: miss marmelstein

I hope this doesn’t mean blood oranges which I occasionally serve.


4 posted on 03/20/2017 2:50:48 PM PDT by miss marmelstein
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To: blam

One I know of that isn’t listed is Methotrexate, which lowers the immune response.


5 posted on 03/20/2017 2:52:11 PM PDT by Don W ( When blacks riot, neighborhoods and cities burn. When whites riot, nations and continents burn.)
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To: blam

Thanks, blam. My husband loves grapefruit juice but has give it up since he was diagnosed with type2 diabetes.


6 posted on 03/20/2017 2:54:43 PM PDT by trisham (Zen is not easy. It takes effort to attain nothingness. And then what do you have? Bupkis.)
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To: blam

Thanks for the warning.

Fortunately, I hate grapefruit.


7 posted on 03/20/2017 2:55:43 PM PDT by Pearls Before Swine
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To: miss marmelstein

Yes it does.


8 posted on 03/20/2017 2:56:26 PM PDT by ifinnegan (Democrats kill babies and harvest their organs to sell)
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To: blam

Thank you for posting. One of mine is on there. I love grapefruit but haven’t had any for a long time. I will avoid them and those other citrus fruits.


9 posted on 03/20/2017 2:57:03 PM PDT by Aliska
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To: Pearls Before Swine

Me too, I never got the appeal of that bitter taste.


10 posted on 03/20/2017 2:59:23 PM PDT by GrandJediMasterYoda (Hillary Clinton IS a felon)
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To: blam

Atorvastatin
Lovastatin
Simvastatin
Felodipine
Nifedipine
Losartan
Eplerenone
Amiodarone
Dronedarone
Erythromycin
Rilpivirine and related HIV drugs
Primaquine and related antimalarial drugs
Albendazole
Bupropion
Quetiapine
Lurasidone
Ziprasidone
Buspirone
Diazepam
Midazolam
Triazolam
Apixaban
Rivaroxaban
Clopidogrel
Ticagrelor
Fentanyl
Oxycodone
Colchicine
Sildenafil
Tadalafil
Tamsulosin
Silodosin

“The bottom line
“Grapefruit interferes with proteins in the small intestine and liver that normally break down many medications.

“Eating grapefruit or drinking grapefruit juice while taking these medications can lead to higher levels in your blood — and more side effects.

“With some drugs, with even small amounts of grapefruit can cause severe side effects. Therefore, the combination should be avoided.

“These drugs may be marked with a grapefruit interaction warning by your pharmacy.

“Make sure your doctor and pharmacist know if you regularly consume grapefruit. They can help you decide whether it’s safe to consume while on certain medications.”


11 posted on 03/20/2017 3:00:24 PM PDT by PIF (They came for me and mine ... now it is your turn ...)
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To: blam

Eat grapefruit. Skip the drugs.


12 posted on 03/20/2017 3:00:39 PM PDT by aMorePerfectUnion
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To: miss marmelstein
Apparently no more then the common orange.

But Mono blood oranges are good for your liver so you might want to check with your doctor to be sure since liver interaction seems to be part of the problem.

13 posted on 03/20/2017 3:01:37 PM PDT by Harmless Teddy Bear (Not a Romantic, not a hero worshiper and stop trying to tug my heartstrings. It tickles! (pink bow))
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To: ifinnegan

Thank you! Good to know.


14 posted on 03/20/2017 3:01:53 PM PDT by miss marmelstein
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To: Harmless Teddy Bear

Ok, thanks.


15 posted on 03/20/2017 3:02:32 PM PDT by miss marmelstein
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To: blam

I LOVE grapefruit.


16 posted on 03/20/2017 3:03:14 PM PDT by TBP (0bama lies, Granny dies.)
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To: miss marmelstein
Hope in your case they turn out to be ok.

I have it daily as part of a fruit juice blend to keep healthy.

17 posted on 03/20/2017 3:04:52 PM PDT by Harmless Teddy Bear (Not a Romantic, not a hero worshiper and stop trying to tug my heartstrings. It tickles! (pink bow))
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To: Pearls Before Swine

If you aren’t on any of the drugs listed, try Ruby Grapefruit which is much sweeter than ordinary grapefruit. Its interior is not yellow but dark pink. Delicious!


18 posted on 03/20/2017 3:05:13 PM PDT by miss marmelstein
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To: Harmless Teddy Bear

Well, we’re now coming to the end of orange/grapefruit season. How I miss grapefruit (I just won’t buy for one) but have been adding blood oranges to our nightly salads! I’ll be careful from now on.


19 posted on 03/20/2017 3:07:14 PM PDT by miss marmelstein
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To: miss marmelstein

I’m more concerned for my wife than myself ... she likes grapefruit. She’s not on any of the afore-mentioned medicines, but with the passage of time, you never can tell.

There’s a tendency to not take these things seriously.

And, come to think of it, every few years, I have occasionally taken erithrymycin, which is on the list.


20 posted on 03/20/2017 3:11:37 PM PDT by Pearls Before Swine
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To: miss marmelstein

I’m more concerned for my wife than myself ... she likes grapefruit. She’s not on any of the afore-mentioned medicines, but with the passage of time, you never can tell.

There’s a tendency to not take these things seriously.

And, come to think of it, every few years, I have occasionally taken erithrymycin, which is on the list.


21 posted on 03/20/2017 3:11:46 PM PDT by Pearls Before Swine
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To: blam

We’ve become a prescription nation. I wonder sometimes how many are actually needed.


22 posted on 03/20/2017 3:13:27 PM PDT by McGruff (#PlugTheLeaks)
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To: blam

would this be the pure juice or the corn syrup sweetened junk juice cocktail you get at the stores/


23 posted on 03/20/2017 3:17:09 PM PDT by SkyDancer (Ambition Without Talent Is Sad, Talent Without Ambition Is Worse)
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To: blam

Pappy sez fiddle ... mix it with vodka and it’ll jazz up things.


24 posted on 03/20/2017 3:19:51 PM PDT by SkyDancer (Ambition Without Talent Is Sad, Talent Without Ambition Is Worse)
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To: PIF

I’ve read grapefruit affects statins like Crestor and generics too.


25 posted on 03/20/2017 3:20:01 PM PDT by tumblindice
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To: miss marmelstein

Pomegranate juice also.


26 posted on 03/20/2017 3:20:46 PM PDT by ifinnegan (Democrats kill babies and harvest their organs to sell)
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To: blam

Conversely, grapefruit juice can also reduce the quantity required of some drugs — and thus improve the efficacy, while reducing side effects. In some cases, that can be a big money-saver (less of an expensive drug required).


27 posted on 03/20/2017 3:25:49 PM PDT by USFRIENDINVICTORIA
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To: McGruff

“We’ve become a prescription nation. I wonder sometimes how many are actually needed.”

Blood pressure reduction is understandable...I’m ok there. But I did tell my doc where to shove his statin drugs.


28 posted on 03/20/2017 3:26:41 PM PDT by BobL (In Honor of the NeverTrumpers, I declare myself as FR's first 'Imitation NeverTrumper')
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To: aMorePerfectUnion; blam

Eat the healthy natural citrus fruit and beware of taking drugs and ingesting processed foods-it works for me-I was brought up in an all-things-natural family...


29 posted on 03/20/2017 3:30:41 PM PDT by Texan5 (`"You've got to saddle up your boys, you've got to draw a hard line"...)
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To: PIF

Sildenafil???

What is the effect of grapefruit on sildenafil?
(viagra...)


30 posted on 03/20/2017 3:32:05 PM PDT by Redbob (W.W.J.B.D. - What Would Jack Bauer Do?)
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To: blam

Crap! One of my meds in on there! I am going to ask my doctor about this.


31 posted on 03/20/2017 3:34:09 PM PDT by ozaukeemom (I am deplorable and proud of it.)
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To: blam

I used to love a greyhound cocktail; vodka and grapefruit with just a wee bit of salt. Can’t have one anymore due to the Lipitor.


32 posted on 03/20/2017 3:36:23 PM PDT by IamConservative (Suppose you were an idiot. And suppose you were a member of Congress. But I repeat myself.)
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To: SkyDancer
Pure juice. Pick it from the tree, peel and eat it and you get the same results.
33 posted on 03/20/2017 3:36:48 PM PDT by Harmless Teddy Bear (Not a Romantic, not a hero worshiper and stop trying to tug my heartstrings. It tickles! (pink bow))
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To: Redbob

OK, by the simple expedient of reading the article, I answered my own question: Grapefruit can cause reduced blood pressure when taken with any of the drugs in the class of PDE-5 inhibitors like Viagra, Cialis, Levitra, and Stendra.

Fortunately for me, reduced bloodpressure would be a good thing!


34 posted on 03/20/2017 3:38:28 PM PDT by Redbob (W.W.J.B.D. - What Would Jack Bauer Do?)
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To: Redbob

Seems like it increases the effect of viagra... Leaving now to buy a crate of grapefruit at Sam’s.


35 posted on 03/20/2017 3:42:29 PM PDT by calico_thompson (Vanity sarcasm)
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To: Don W

“One I know of that isn’t listed is Methotrexate, which lowers the immune response.”

Just came off of that. Nasty drug.


36 posted on 03/20/2017 3:49:01 PM PDT by EQAndyBuzz (Nuke Bilderberg from orbit. It's the only way to be sure.)
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To: PIF

Where is Rotunzapine on the list?


37 posted on 03/20/2017 3:50:53 PM PDT by Klemper
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To: BobL

Statins, ugh. No warnings I recall, I was eating grapefruit and taking GENERIC NAME: rosuvastatin BRAND NAME: Crestor.
Muscle pain and aches, other problems.
Don’t know if the grapefruit was a problem or if just made the statin side-effects worse, or if it was just the statin.
But I could tell something was wrong. Anyway my cholesterol was down, I lost weight, better diet, exercised and discontinued it. Everything seems copacetic now.


38 posted on 03/20/2017 3:56:47 PM PDT by tumblindice
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To: aMorePerfectUnion

Oil the gun. Eat the cannoli.


39 posted on 03/20/2017 3:57:49 PM PDT by Noumenon ("Only the dead have seen an end to war.")
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To: ozaukeemom

One would think that a Doctor would know these things and tell his patients.

Well, a good doctor at least.


40 posted on 03/20/2017 4:00:10 PM PDT by American in Israel (A wise man's heart directs him to the right, but the foolish mans heart directs him toward the left.)
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To: blam

Bkmrk. Love Ruby Red.


41 posted on 03/20/2017 4:08:59 PM PDT by RushIsMyTeddyBear (****happy dance**** BIGLY!!!! Shadilay!)
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To: RushIsMyTeddyBear

.......With seltzer for a bit of fizz.


42 posted on 03/20/2017 4:10:00 PM PDT by RushIsMyTeddyBear (****happy dance**** BIGLY!!!! Shadilay!)
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To: blam

this fruit is NOT to be eaten by those on warfarin (COUMADIN) as well. No Grapefruit, no cranberry sauce, no green leafy vegetables - ie. lettuce, broccoli


43 posted on 03/20/2017 4:11:50 PM PDT by V K Lee (If all the nations in the world are in debt, where did all the money go?)
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To: Harmless Teddy Bear

Just saying - anyway that garbage they sell in supermarkets is not juice but a juice cocktail. Even the label is misleading stating “pure juice” ... well yeah, you want cranberry juice? Well it says right there on the label “pure juice” and the second two ingredients are apple and grape followed by cranberry and loaded out with corn syrup with the secondary juices added to fill the bottle. I hate that. Better to take a cranberry pill or a grapefruit pill if you’re so inclined.


44 posted on 03/20/2017 4:17:00 PM PDT by SkyDancer (Ambition Without Talent Is Sad, Talent Without Ambition Is Worse)
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To: RushIsMyTeddyBear
If your grocery stores carry Polar Sodas/Seltzers
try their Pink Grapefruit Dry Soda ( and seltzer too) they're spectacular!
(I mix them 1/2&1/2)


45 posted on 03/20/2017 4:18:15 PM PDT by libertarian27 (FR Cookbooks - On Profile Page)
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To: blam

A to Z
Albendazole
Amiodarone
Apixaban
Atorvastatin
Bupropion
Buspirone
Clopidogrel
Colchicine
Diazepam
Dronedarone
Eplerenone
Erythromycin
Felodipine
Fentanyl
Losartan
Lovastatin
Lurasidone
Midazolam
Nifedipine
Oxycodone
Primaquine and related antimalarial drugs
Quetiapine
Rilpivirine and related HIV drugs
Rivaroxaban
Sildenafil
Silodosin
Simvastatin
Tadalafil
Tamsulosin
Ticagrelor
Triazolam
Ziprasidone

Thanks


46 posted on 03/20/2017 4:23:08 PM PDT by freeonefrom (God bless America and our troops.)
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To: blam

Mmmmm, it taste like bile so everythng tastes better after after you drink the juice.


47 posted on 03/20/2017 4:23:54 PM PDT by right way right (May we remain sober over mere men, for God really is our one and only true hope.)
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To: Redbob

48 posted on 03/20/2017 4:31:17 PM PDT by Phil DiBasquette
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To: blam

Oh, rats! I love grapefruit and two of my meds were on the list. Bye bye, beloved fruit! Sob!


49 posted on 03/20/2017 4:34:28 PM PDT by Hootowl
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To: libertarian27

I will! Thanks!


50 posted on 03/20/2017 4:38:05 PM PDT by RushIsMyTeddyBear (****happy dance**** BIGLY!!!! Shadilay!)
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