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Sniff test' may be useful in diagnosing early Alzheimer's disease
Science Daily ^ | 12/21/2016 | University of Pennsylvania School of Medicine

Posted on 12/21/2016 9:27:20 PM PST by JimSEA

Tests that measure the sense of smell may soon become common in neurologists' offices. Scientists have been finding increasing evidence that the sense of smell declines sharply in the early stages of Alzheimer's, and now a new study from the Perelman School of Medicine at the University of Pennsylvania published in the Journal of Alzheimer's Disease confirms that administering a simple "sniff test" can enhance the accuracy of diagnosing this dreaded disease.

The sniff test also appears to be useful for diagnosing a pre-dementia condition called mild cognitive impairment (MCI), which often progresses to Alzheimer's dementia within a few years.

Neurologists have been eager to find new ways to identify people who are at high risk of Alzheimer's dementia but do not yet show any symptoms. There is a widespread consensus that Alzheimer's medications now under development may not work after dementia has set in.

(Excerpt) Read more at sciencedaily.com ...


TOPICS: Health/Medicine; Science
KEYWORDS: alzheimers
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"There's the exciting possibility here that a decline in the sense of smell can be used to identify people at risk years before they develop dementia," said principal investigator David R. Roalf, PhD, an assistant professor in the department of Psychiatry at Penn.

Roalf and his colleagues used a simple, commercially available test known as the Sniffin' Sticks Odor Identification Test, in which subjects must try to identify 16 different odors. They administered the sniff test, and a standard cognitive test (the Montreal Cognitive Assessment), to 728 elderly people.

There seems to be a significant increase in reliability combined with cognitive impairment tests alone for mild cognitive impairment (MCI).

1 posted on 12/21/2016 9:27:20 PM PST by JimSEA
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To: JimSEA

I guess I was born with dementia. My smeller has been marginal since I was a kid. By the time I smell the gas leak everyone else is dead.


2 posted on 12/21/2016 10:06:27 PM PST by arthurus
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To: JimSEA

I can still smell my farts, so I guess I’m okay for now.


3 posted on 12/21/2016 10:10:20 PM PST by roadcat
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To: arthurus

In that case, you don’t need to smell the gas — Just watch for people dropping dead and you’ll know there’s a gas leak. :=)


4 posted on 12/21/2016 10:10:48 PM PST by Bob (Now, Republicans get to sing "Happy Days Are Here Again". Enjoy the suck, rats.)
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To: Bob
Back in 71 I was living with my wife and two small daughters and a dog in a small house in St Petersburg FL. Wife was at class. It was early afternoon I had the girls and was trying to study for my own upcoming exam. I was terribly sleepy and so were the girls and the dog. They were all asleep. I wanted to just go to sleep but knew I must study the material. I got up and went into the kitchen to heat water to make instant coffee. The little gas stove that you have to light with a match had all four burners turned on with no flame. I dropped the cup I was holding and ran into the living room, scooped up one kid and put her out on the lawn, went back in and got the other kid and then went in and got the dog. Everybody woke up and everybody had a headache. Some toddler fingers had been fiddling with the knobs. I subsequently shut off the gas line and got a two burner electric hotplate.
5 posted on 12/21/2016 10:47:09 PM PST by arthurus
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To: arthurus

Holy crap!!!! I mistakenly took your post as a bit of a exaggeration, sorry. It’s amazing that you and your family survived that.


6 posted on 12/21/2016 11:01:11 PM PST by Bob (Now, Republicans get to sing "Happy Days Are Here Again". Enjoy the suck, rats.)
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To: JimSEA

I heard, some years back, that one VERY early indicator of demntia/Alzheimers is excessive neatness in a child.

The kid whose desk was the teacher’s model for what a desk should look like and whose room was always picture perfect.

Of the couple people I know who had Alzheimers, they were very neat, one compulsively so.

I’m safe and so is mr. mm for sure.......


7 posted on 12/21/2016 11:05:35 PM PST by metmom (...fixing our eyes on Jesus, the Author and Perfecter of our faith...)
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To: arthurus

Scary story! Thank God you were awake enough to figure it out and save everybody.


8 posted on 12/21/2016 11:11:11 PM PST by thecodont
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To: JimSEA

A baseline Odor Identification Test in the earlier years would make sense.


9 posted on 12/21/2016 11:20:39 PM PST by Gene Eric (Don't be a statist!)
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To: thecodont

Since then on one occasion in a full parish hall I noticed that all the small children were asleep and I was feeling sleepy, not compellingly so, but sleepy. I remembered the incident in St. Pete and went forward to tell the MC that I thought there was a gas leak in the heating system. He sniffed, and said I think you are right and told everyone to go out into the parking lot while he and I opened all the windows. I called my buddy who had an appliance repair business to come over and he did ten minutes later and smelled it. He hunted it down and fixed it and gave the system a thorough inspection and fixed a couple of other things, too.


10 posted on 12/21/2016 11:21:55 PM PST by arthurus
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To: arthurus

Wow that was close. Glad your story had a happy ending.


11 posted on 12/21/2016 11:29:19 PM PST by Rusty0604
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To: arthurus

Great story. It would make someone think twice about being in a building with any sort of gas heating.


12 posted on 12/21/2016 11:30:26 PM PST by thecodont
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To: arthurus
I guess I was born with dementia. My smeller has been marginal since I was a kid. By the time I smell the gas leak everyone else is dead.

That's why God created canaries.

13 posted on 12/21/2016 11:34:36 PM PST by cynwoody
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To: Gene Eric

As this is effective for mild cognitive impairment, you’re doubtless correct.


14 posted on 12/21/2016 11:59:43 PM PST by JimSEA
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To: metmom

Hope you’re right. My immediate family is okay then. Slobs but okay.


15 posted on 12/22/2016 12:01:33 AM PST by JimSEA
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To: arthurus

I was just visiting a store that sells scented candles. I couldn’t smell any of them. But this has been going on for years so I don’t think I have Alzheimer’s.


16 posted on 12/22/2016 12:40:15 AM PST by wideminded
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To: wideminded

...”I was just visiting a store that sells scented candles. I couldn’t smell any of them. But this has been going on for years so I don’t think I have Alzheimer’s.”...

I lost my sense of smell after taking a hard fall on my face and I can say that I really miss it and the sense of taste which also goes. Many people lose their sense of smell as they get older. In the end this test may prove not to be as effective as they think.


17 posted on 12/22/2016 3:11:34 AM PST by jazzlite (esat)
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To: jazzlite

Zicam, baby. Took it right out.


18 posted on 12/22/2016 3:15:14 AM PST by AppyPappy (If you really want to irritate someone, point out something obvious they are trying hard to ignore.)
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To: arthurus

Yep - long term sinus issues - even after “corrective” surgery. My wife can smell things and react strongly when I haven’t a clue that something stinks - she’s gonna have to be my brain in my declining years....


19 posted on 12/22/2016 4:03:59 AM PST by trebb (Where in the the hell has my country gone?)
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To: JimSEA

This is scary. I’ve lost my sense of smell over the last 6 months. The only thing I can smell is a constant odor of cigarette smoke, but no one around me smokes. I guess it’s time to make a doctor’s appointment.

Alzheimer’s runs in my family and it’s been one of my biggest fears since watching my grandmother deteriorate. She was a sweet, friendly woman until she developed Alzheimer’s and then she became mean. She would kick us as we walked by and mistreat her dog. It was sad to watch.


20 posted on 12/22/2016 6:21:41 AM PST by mbynack (Retired USAF SMSgt)
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