Posted on 12/16/2011 6:24:44 PM PST by decimon
Adding inhaled dry powder mannitol to standard therapy for cystic fibrosis produced sustained improvement in lung function for up to 52 weeks, according to a new study. Along with the treatment's efficacy and good safety profile, the convenience and ease of administration of mannitol treatment may improve adherence with therapy in these patients.
In the double-blind study, which was supported by Pharmaxis Limited, 318 patients were randomized to treatment with 400 mg bid inhaled mannitol or 50 mg bid inhaled mannitol (control group) for 26 weeks, followed by an additional 26 weeks of open-label active treatment. A 50 mg dose was chosen as the control because it was felt it would not be clinically effective, based on an earlier dose escalation study. Mannitol was given on top of a background of typical concomitant therapy such as recombinant human deoxyribonuclease and inhaled antibiotics.
The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
"Patients in the treatment group showed a 106.5 mL mean improvement in forced expiratory volume in one second (FEV1), an 8.22 percent improvement from baseline, compared with a 52.4 mL improvement (4.47 percent) in the control group," said lead author Moira L. Aitken, MD, professor of pulmonary and critical care medicine at the University of Washington Medical Center. "Forced vital capacity increased 136.3 mL in the treatment group, compared with 65.0 mL in the control group. Treated patients also experienced fewer pulmonary exacerbations than controls."
(Excerpt) Read more at eurekalert.org ...
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bkmk
Wow! I only used mannitol in brain injuries. (Diuretic effect—I’m old—please excuse.)
I recognized the name as a sweetener in 'sugar free' products.
That does it!! I’m off the coke and am only going to snort mannitol from now on. And I’m using my super powers for good instead of evil. I’m keeping the cape though.
Lots of heads thought they were getting Peruvian Marchin Powder and really got lots of mannitol. Guess you could say they were getting CF pre-treatment.
Mannitol...with or without the cocaine?
Yes, something about the molecule (size, maybe) attracts water and remains outside the cell membrane (not absorbed.) Where are the molecular biological pharmaceuticokinetecists (I made that up) when you need them?
Mannatech, Inc., is a multi level marketing company with patents concerning polysaccharides, such as mannitol.
Do a search on “long term survivors aids mannose” which is a related saccharide.
Harvested from the aloe vera cactus, then stabilized.
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