Posted on 08/18/2010 3:32:38 AM PDT by decimon
Researchers have made a discovery that could lead to a brand new class of drugs to treat chronic pain caused by inflammatory conditions such as arthritis and back pain without numbing the whole body.
The team, funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and working at UCL (University College London), have shown for the first time that genes involved in chronic pain are regulated by molecules inside cells called small RNAs. This mechanism is so different from what has already been discovered about the biology underpinning pain that it could be the Achilles heel of chronic inflammatory pain, which is notoriously difficult to treat. The research appears in The Journal of Neuroscience.
Lead researcher Professor John Wood from UCL said "When a person experiences chronic pain as a result of some sort of inflammation - as in arthritis - their pain threshold goes down very dramatically. What they can normally do without pain, such as walking or putting on clothes, becomes very painful.
"Chronic inflammatory pain can be treated with pain-killing drugs - analgesics - but these usually have an impact on the whole body and may also dull our experience of acute pain, which is actually very important as it protects us from injury. Just imagine if you didn't get a sharp pain when you accidentally touch the oven - you wouldn't be compelled to take your hand away quickly and could end up with a serious burn.
"What we would really like to be able to do is return the pain thresholds to normal in a person who has chronic inflammatory pain, rather than just numbing the whole body. This would mean that they still get the protection of acute pain. Currently, aspirin-like drugs that can do this have a number of side effects but the present discovery might make it possible to invent a class of drugs that act in a completely novel way."
The researchers studied mice that lack an enzyme called Dicer in some of their nerve cells and found that they respond normally to acute pain but don't seem to be bothered by anything that would usually cause chronic inflammatory pain. This is because Dicer makes small RNAs, which they now know are required for regulation of genes involved in chronic inflammatory pain. Without Dicer the small RNAs aren't made and without the small RNAs many of these genes are expressed at low levels. So, for example, molecules such as sodium channels that make pain nerves responsive to inflammation are produced at low levels and therefore inflammatory pain is not detected by the mouse's body.
Professor Wood concluded "Knowing that small RNAs are so important in chronic inflammatory pain provides a new avenue for developing drugs for some of the most debilitating and life-long conditions out there. We have identified small RNAs, which are possible drug targets"
Professor Douglas Kell, BBSRC Chief Executive said "It is extremely important to be able to find out as much as possible about the fundamental processes of 'normal' biology, as a vehicle for understanding what may go wrong. Because these researchers have made efforts to unpick what is happening at a molecular level in our nerves, they have been able to lay the groundwork for future drug development in the important area of chronic pain. This is an excellent example of the basic research we have to do to help ensure that our increasing lifespan does not mean that the later years of our lives are spent in ill health and discomfort."
ENDS Notes to editors
This research is published in The Journal of Neuroscience. An online edition of the research paper is available as follows:
Zhao et al., "Small RNAs Control Sodium Channel Expression, Nociceptor Excitability, and Pain Thresholds", The Journal of Neuroscience, 2010, 30(32):10860-10871; doi:10.1523/JNEUROSCI.1980-10.2010 at: http://bit.ly/c5BQKv About UCL
Founded in 1826, UCL was the first English university established after Oxford and Cambridge, the first to admit students regardless of race, class, religion or gender, and the first to provide systematic teaching of law, architecture and medicine. UCL is the fourth-ranked university in the 2009 THES-QS World University Rankings. UCL alumni include Marie Stopes, Jonathan Dimbleby, Lord Woolf, Alexander Graham Bell, and members of the band Coldplay. UCL currently has over 12,000 undergraduate and 8,000 postgraduate students. Its annual income is over £600M. About BBSRC
BBSRC is the UK funding agency for research in the life sciences. Sponsored by Government, BBSRC annually invests around £470M in a wide range of research that makes a significant contribution to the quality of life in the UK and beyond and supports a number of important industrial stakeholders, including the agriculture, food, chemical, healthcare and pharmaceutical sectors.
BBSRC provides institute strategic research grants to the following:
* The Babraham Institute * Institute for Animal Health * Institute for Biological, Environmental and Rural Studies (Aberystwyth University) * Institute of Food Research * John Innes Centre * The Genome Analysis Centre * The Roslin Institute (University of Edinburgh) * Rothamsted Research
The Institutes conduct long-term, mission-oriented research using specialist facilities. They have strong interactions with industry, Government departments and other end-users of their research. Contact
Nancy Mendoza, Senior Media Officer nancy.mendoza@bbsrc.ac.uk tel: 01793 413355 fax: 01793 413382
Tracey Jewitt, Media Officer tracey.jewitt@bbsrc.ac.uk tel: 01793 414694 fax: 01793 413382
Matt Goode, Deputy Head of External Relations matt.goode@bbsrc.ac.uk tel: 01793 413299 fax: 01793 413382
Ping
Wonderful advance, but Obamacare will not let you have it because it is too expensive. Sorry!
This story is from Great Britian. If BritCare lets you have it, ObamaCare will! Mmm, Mmm, Mmm!
Sounds promising. Hope they hurry. 1600 mg. of prescription Ibuprofen, 440 mg. Naproxen and various joint juice daily isn't packing the punch it used to. Sometimes I'd almost give a thousand dollars for a 6 hour morphine drip just to sleep.
Or, you can simply quit eating all of the sugar and junk that drives the inflamation in the first place.
My goodness! What then will those who “suffer” from “fibromyalgia” have to bitch about? Perhaps they’ll be forced to admit that they are really nothing more than self-absorbed individuals wallowing in self-pity and and a touch of hypochondria.
I have yet to know an individual claiming to suffer from that crap to actually be a person of self-reliance and possessing a positive outlook.
amen to that!
Have you tried Vitamin C in large doses? Specifically from Lemon juice?
Research it.
Hey, thanks man, I’ve been going through terrible inflammation, going to give it a try ....
Well, not large doses just 500 Ester C. I have a lemon tree and keep wedges in my water all winter season until they run out. I just took another 1000 of the Ester. I’ll do the research, thanks. Honestly, I’ll try anything short of opiates!
Important note - Unlike other vitamins, too much C just passes thru, there is no known LD, however increase slowly because it is a liver stimulator.
The best and fastest acting sources are from foods not pills.
The lemon juice seems to me to be the strongest and fastest acting. A couple of tablespoons in 8 or so ounces of water will do.
FWIW, I posted something a while ago that claimed an immune system benefit to soluble fiber as in citrus fruit. If there's anything to that then you might want your lemon, grapefruit, whatever with its pulp.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.